Application of concentrated growth factor in regenerative endodontic treatment of immature permanent tooth with periapical periodontitis: Two cases and literature review

doi:10.3877/cma.j.issn.1674-1366.2023.02.003

Chinese Journal of Stomatological Research(Electronic Edition) ›› 2023, Vol. 17 ›› Issue (02): 81-88. doi: 10.3877/cma.j.issn.1674-1366.2023.02.003

Special Issue: ；

• Pediatric Dentistry Column·Case Analysis • Previous Articles Next Articles

Application of concentrated growth factor in regenerative endodontic treatment of immature permanent tooth with periapical periodontitis: Two cases and literature review

Junhui Wang¹, Ying Hu¹, Fang Liu¹, Fei Wang¹, Yujiang Chen¹, Xiaojing Wang¹^,^†()

^1. State Key Laboratory of Military Stomatology & National Clinical Research Center for Oral Disease & Shaanxi Clinical Research Center for Oral Diseases, Stomatology Department of Children, School of Stomatology, The Fourth Military Medical University, Xi′an 710032, China

Received:2023-02-05 Online:2023-04-01 Published:2023-04-20
Contact: Xiaojing Wang
Supported by:
Special Project of National Clinical Research Center for Oral Diseases(LCA202010); National Natural Science Foundation(Youth Program, 82100954); Shaanxi Provincial Key R&D Program(2022KW-12); Independent Research Project of the State Key Laboratory of Military Stomatology(2019ZA06)

Abstract

Abstract:

Concentrated growth factor (CGF) is a kind of platelet concentrate, which is a fibrin block rich in growth factors. CGF is prepared by blood samples with special centrifugal equipment, and has good plasticity and regeneration promotion ability. Growth factor can be used as a good scaffold matrix, which can attract undifferentiated mesenchymal cells to the corresponding sites, promoting angiogenesis and cell proliferation. Fibrin with three-dimensional reticular structure can improve the adherence of growth factors, white blood cells and fibroblasts to the protein surface, provide a matrix for cell proliferation and differentiation, and ultimately promote the repair of pulp tissue.

Key words: Concentrated growth factor, Immature permanent teeth, Periapical periodontitis, Regenerative endodontic therapy

Junhui Wang, Ying Hu, Fang Liu, Fei Wang, Yujiang Chen, Xiaojing Wang. Application of concentrated growth factor in regenerative endodontic treatment of immature permanent tooth with periapical periodontitis: Two cases and literature review[J]. Chinese Journal of Stomatological Research(Electronic Edition), 2023, 17(02): 81-88.

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