The clinical effect of "sticky bone" mixed with concentrated growth factor on patients with horizontal bone augmentation

doi:10.3877/cma.j.issn.1674-1366.2023.06.010

Abstract

Abstract:

Objective

To study the effectiveness of sticky bone mixed with concentrated growth factor (CGF) on bone augmentation in patients with horizontal ridge defect.

Methods

A total of 40 patients with dentition defect (one tooth loss) who were treated in the Department of Oral and Maxillofacial Surgery, Jinan Stomatological Hospital from September 2021 to February 2023 were included in the study. Participants were randomly divided into the control group receiving guided bone regeneration (GBR) with Bio-Oss bone substitute, and the experimental group receiving GBR with sticky bone mixed with CGF. The success rate of osseointegration, alveolar bone width, gained bone width at 6 months after surgery, operation time and postoperative complications were compared between the two groups.

Results

The success rate of osseointegration in both groups was 100%. The alveolar bone width of the experimental group and the control group at 6 months after surgery was (8.3 ± 0.8) mm and (7.1 ± 1.0) mm, respectively, both of which was larger than that before surgery [ (3.6 ± 0.6) mm and (3.8 ± 0.8) mm], and the difference was statistically significant (t_e = 22.13, t_c = 11.99, P<0.001). The alveolar bone width (t₂) and gained bone width (t₂-t₀) in the experimental group were (8.3 ± 0.8) mm and (4.7 ± 0.7) mm, respectively, which were higher than those in the control group [ (7.1 ± 1.0) mm and (3.3 ± 0.8) mm], and the difference was statistically significant (t_t2 = -4.406, t_t2-t0 = 5.978, P<0.001). The operation time of bone augmentation in the experimental group [ (6.5 ± 1.1) min] was significantly lower than that in the control group [ (8.1 ± 1.3) min] (t = 4.196, P<0.001). No serious postoperative complications occurred.

Conclusions

Compared with the GBR technique using Bio-Oss bone substitute, the GBR technique using sticky bone mixed with CGF had better outcome in horizontal bone augmentation. However, further studies on its long-term effect are needed.

Key words: Bone augmentation, Guided bone regeneration, Sticky bone, Concentrated growth factor

Zhenjiang Gong, Shouyi Wang, Chao Yao, Yongzhi Pang, Jing Cui. The clinical effect of "sticky bone" mixed with concentrated growth factor on patients with horizontal bone augmentation[J]. Chinese Journal of Stomatological Research(Electronic Edition), 2023, 17(06): 430-435.

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References 31

[1]	Pagni G，Pellegrini G，Giannobile WV，et al. Postextraction alveolar ridge preservation：Biological basis and treatments[J]. Int J Dent，2012：151030. DOI：10.1155/2012/151030.
[2]	Schropp L，Wenzel A，Kostopoulos L，et al. Bone healing and soft tissue contour changes following single-tooth extraction：A clinical and radiographic 12-month prospective study[J]. Int J Periodontics Restorative Dent，2003，23（4）：313-323.
[3]	Wilson TG Jr，Buser D. Advances in the use of guided tissue regeneration for localized ridge augmentation in combination with dental implants[J]. Tex Dent J，1994，111（7）：5，7-10.
[4]	Hermann JS，Buser D. Guided bone regeneration for dental implants[J]. Curr Opin Periodontol，1996，3：168-177.
[5]	Wang HL，Boyapati L. "PASS" principles for predictable bone regeneration[J]. Implant Dent，2006，15（1）：8-17. DOI：10.1097/01.id.0000204762.39826.0f.
[6]	段彦好，肖旭辉.浓缩生长因子用于口腔骨组织再生的研究进展[J].北京口腔医学，2023，31（4）：291-294. DOI：10.20049/j.bjkqyx.1006-673X.2023.04.011.
[7]	胡小敏，唐正龙，王冬香.浓缩生长因子在口腔领域骨再生的研究进展[J].临床口腔医学杂志，2023，39（4）：252-255. DOI：10.3969/j.issn.1003-1634.2023.04.016.
[8]	郭雅欣，王姝.浓缩生长因子在口腔中骨缺损方向的应用进展[J].中华老年口腔医学杂志，2023，21（1）：61-64. DOI：10.19749/j.cn.cjgd.1672-2973.2023.01.011.
[9]	刘雨蒙，袁长永.浓缩生长因子软组织封闭功能在口腔种植中的应用[J].中国口腔种植学杂志，2021，26（6）：396-399. DOI：10.12337/zgkqzzxzz.2021.12.011.
[10]	Sohn DS，Huang B，Kim J，et al. Utilization of autologous concentrated growth factors（CGF）enriched bone graft matrix （sticky bone）and CGF-enriched fibrin membrane in implant dentistry[J]. J Implant & Advanced Clin Dent，2015，7：11-29.
[11]	张富贵，宿玉成，邱立新，等.牙槽骨缺损骨增量手术方案的专家共识[J].口腔疾病防治，2022，30（4）：229-236. DOI：10.12016/j.issn.2096-1456.2022.04.001.
[12]	Sharma MS，Pandey V，Vartak V，et al. Prosthetic Driven Implantology—A Review[J]. Int J Res Health Allied Sci，2016，2（3）：21-25.
[13]	Gultekin BA，Cansiz E，Yalcin S. Ridge augmentation techniques in preprosthetic implant surgery[M]//A Textbook of Advanced Oral and Maxillofacial Surgery. Volume 3. 2016：245-268. DOI：10.5772/63003.
[14]	Cha HS，Kim JW，Hwang JH，et al. Frequency of bone graft in implant surgery[J]. Maxillofac Plast Reconstr Surg，2016，38（1）：19. DOI：10.1186/s40902-016-0064-2.
[15]	Farina R，Pramstraller M，Franceschetti G，et al. Alveolar ridge dimensions in maxillary posterior sextants：A retrospective comparative study of dentate and edentulous sites using computerized tomography data[J]. Clin Oral Implants Res，2011，22（10）：1138-1144. DOI：10.1111/j.1600-0501.2010.02087.x.
[16]	Braut V，Bornstein MM，Kuchler U，et al. Bone dimensions in the posterior mandible：A retrospective radiographic study using cone beam computed tomography. Part 2—analysis of edentulous sites[J]. Int J Periodontics Restorative Dent，2014，34（5）：639-647. DOI：10.11607/prd.1895.
[17]	Wessing B，Lettner S，Zechner W. Guided bone regeneration with collagen membranes and particulate graft materials：A systematic review and meta-analysis[J]. Int J Oral Maxillofac Implants，2018，33（1）：87-100. DOI：10.11607/jomi.5461.
[18]	Benic GI，Hämmerle CH. Horizontal bone augmentation by means of guided bone regeneration[J]. Periodontol 2000，2014，66（1）：13-40. DOI：10.1111/prd.12039.
[19]	雷晨，吴奇蓉，汤春波.浓缩生长因子在种植与牙周领域应用的研究及进展[J].中国口腔种植学杂志，2021，26（2）：135-140. DOI：10.12337/zgkqzzxzz.2021.04.011.
[20]	Adalı E，Yüce MO，Günbay T，et al. Does concentrated growth factor used with allografts in maxillary sinus lifting have adjunctive benefits？[J]. J Oral Maxillofac Surg，2021，79（1）：98-108. DOI：10.1016/j.joms.2020.07.217.
[21]	Yamada M，Egusa H. Current bone substitutes for implant dentistry[J]. J Prosthodont Res，2018，62（2）：152-161. DOI：10.1016/j.jpor.2017.08.010.
[22]	岳喜龙，许胜，柳忠豪，等.骨劈开技术与Onlay植骨技术用于上颌前牙美学区临床效果的对照研究[J].中国口腔种植学杂志，2018（2）：61-65. DOI：CNKI:SUN:KQZZ.0.2018-02-003.
[23]	Barbu HM，Iancu SA，Rapani A，et al. Guided bone regeneration with concentrated growth factor enriched bone graft matrix（sticky bone）vs. bone-shell technique in horizontal ridge augmentation：A retrospective study[J]. J Clin Med，2021，10（17）：3953. DOI：10.3390/jcm10173953.
[24]	曾千情，苏浩宇，汪鼎傑，等.浓缩生长因子为基质的黏性骨块在上颌前牙区水平骨增量中应用效果研究[J].中国实用口腔科杂志，2023，16（3）：320-325. DOI：10.19538/j.kq.2023.03.012.
[25]	李永军，陈福磊，门贝. Sticky Bone联合CGF应用于窄牙槽嵴种植修复[J].临床口腔医学杂志，2023，39（4）：194+255. DOI：10.3969/j.issn.1003-1634.2023.04.001.
[26]	王毅，万哲，刘杨，等. CGF纤维蛋白液体联合Bio-Oss骨粉对上前牙缺失伴唇侧骨缺损患者种植的疗效[J].中国医药导报，2018，15（12）：106-109.
[27]	王亚敏，周震，刀俊峰，等.浓缩生长因子应用于上颌前牙区骨缺损引导骨再生的效果评价[J].口腔疾病防治，2020，28（4）：236-240. DOI：10.12016/j.issn.2096-1456.2020.04.006.
[28]	靳夏莹，那日苏，郑辉，等.评价富血小板纤维蛋白单独用于上颌窦提升种植骨再生的效果[J].中国组织工程研究，2017，21（26）：4149-4154. DOI：10.3969/j.issn.2095-4344.2017.26.009.
[29]	Ayoub AH，Belal SM. Clinical and radiographic evaluation of socket preservation using autologous concentrated growth factors enriched bone graft matrix（sticky bone）：A case report[J]. EC Dental Science，2016，5（4）：1128-1135.
[30]	Masuki H，Okudera T，Watanebe T，et al. Growth factor and pro-inflammatory cytokine contents in platelet-rich plasma（PRP），plasma rich in growth factors（PRGF），advanced platelet-rich fibrin（A-PRF），and concentrated growth factors（CGF）[J]. Int J Implant Dent，2016，2（1）：19. DOI：10.1186/s40729-016-0052-4.
[31]	Upadhayaya V，Arora A，Goyal A. Bioactive platelet aggregates：Prp，Prgf，Prf，Cgf and sticky bone[J]. IOSR Journal of Dental and Medical Sciences，2017，16（5）：5-11. DOI：10.9790/0853-1605060511.

组别	例数	术前（t₀）	术后即刻（t₁）	术后6个月（t₂）	骨增量（t₂-t₀）
对照组	20	3.8 ± 0.8	7.9 ± 0.7	7.1 ± 1.0	3.3 ± 0.8
研究组	20	3.6 ± 0.6	9.0 ± 0.5	8.3 ± 0.8	4.7 ± 0.7
t值		0.975	4.929	4.406	5.978
P值		0.336	<0.001	<0.001	<0.001

组别	例数	术前（t₀）	术后即刻（t₁）	术后6个月（t₂）	骨增量（t₂-t₀）
对照组	20	3.8 ± 0.8	7.9 ± 0.7	7.1 ± 1.0	3.3 ± 0.8
研究组	20	3.6 ± 0.6	9.0 ± 0.5	8.3 ± 0.8	4.7 ± 0.7
t值		0.975	4.929	4.406	5.978
P值		0.336	<0.001	<0.001	<0.001

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