Research progress on programmed cell death in periapical periodontitis

doi:10.3877/cma.j.issn.1674-1366.2024.03.002

Abstract

Abstract:

Programmed cell death (PCD) is a genetically determined, active, and orderly way of cell death, closely associated with the progression of periapical diseases. Various PCD pathways have been identified in periapical lesions, including apoptosis, autophagy, necroptosis, pyroptosis, and ferroptosis. These pathways can be activated by both endogenous and exogenous stimuli, playing crucial roles in maintaining homeostasis and regulating inflammation. This article provided a comprehensive review of the roles of different PCD pathways in periapical diseases, aiming to explore the pathogenesis and target regulatory molecules of periapical diseases, thereby offering new insights into their prevention and treatment.

Key words: Programmed cell death, Periapical periodontitis, Apoptosis, Autophagy, Necroptosis, Pyroptosis, Ferroptosis

Zekai Liao, Ailin Liang, Qimei Gong. Research progress on programmed cell death in periapical periodontitis[J]. Chinese Journal of Stomatological Research(Electronic Edition), 2024, 18(03): 150-155.

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