The relationship between CD4-positive T-lymphocytes and periodontitis

doi:10.3877/cma.j.issn.1674-1366.2017.03.009

Abstract

Abstract:

Periodontitis, a chronic inflammatory disease caused by a variety of microbes, causes periodontal tissue damage associated with the host immune response inducing inflammation. It′s widely accepted that the occurrence and development of periodontitisis associated with patients′ immune status can be partly reflected by CD4-positive T-lymphocytes (CD4⁺T cells) . Their relationship with periodontitis has become a hotspot in recent years. This review summarizes the recent studies on the differentiation and function of CD4⁺T cells and their relationship with periodontitis, and aims to elucidate the role of CD4⁺T cells in the genesis and progression of periodontitis.

Key words: Periodontitis, CD4-positive T-lymphocytes, Th1 cells, Th2 cells, Th17 cells

Kunman Li, Jing Dai, Jing Ren, Shan Chen, Yanbin Chen, Junying Yang. The relationship between CD4-positive T-lymphocytes and periodontitis[J]. Chinese Journal of Stomatological Research(Electronic Edition), 2017, 11(03): 178-183.

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References 59

[1]	Hajishengallis G. Periodontitis：from microbial immune subversion to systemic inflammation[J]. Nat Rev Immunol，2015，15(1):30-44.
[2]	Cekici A, Kantarci A, Hasturk H，et al. Inflammatory and immune pathways in the pathogenesis of periodontal disease[J]. Periodontol 2000，2014,64(1):57-80.
[3]	王琳源，靳赢，林晓萍.适应性免疫应答在牙周炎发生中的作用[J].中华口腔医学杂志，2013，48(2):115-118.
[4]	Scripture-Adams DD, Damle SS, Li L，et al. GATA-3 dose-dependent checkpoints in early T cell commitment[J]. J Immunol，2014，193(7):3470-3491.
[5]	Zhu J, Paul WE. CD4 T cells：fates，functions，and faults[J]. Blood，2008，112(5):1557-1569.
[6]	Mosmann TR, Coffman RL. TH1 and TH2 cells：different patterns of lymphokine secretion lead to different functional properties[J]. Annu Rev Immunol，1989(7):145-173.
[7]	Bluestone JA, Mackay CR, O'Shea JJ，et al. The functional plasticity of T cell subsets[J]. Nat Rev Immunol，2009，9(11):811-816.
[8]	Luo J, Zhang M, Yan B，et al. Imbalance of Th17 and Treg in peripheral blood mononuclear cells of active tuberculosis patients[J]. Braz J Infect Dis，2017，21(2):155-161.
[9]	Chen X, Wang J, Wang R，et al. Th1-，Th2-，and Th17-associated cytokine expression in hypopharyngeal carcinoma and clinical significance[J]. Eur Arch Otorhinolaryngol，2016，273(2):431-438.
[10]	Zambrano-Zaragoza JF, Romo-Martinez EJ, Duran-Avelar Mde J，et al. Th17 cells in autoimmune and infectious diseases[J]. Int J Inflam，2014:651503.
[11]	Awasthi A, Kuchroo VK. Th17 cells：from precursors to players in inflammation and infection[J]. Int Immunol，2009，21(5):489-498.
[12]	王晨宇，王星，王琳，等. Th17细胞分化调节机制及与自身免疫性疾病关系研究进展[J].细胞与分子免疫学杂志，2014，30(6):660-662.
[13]	周洲，冯娟，王宪.调节性T细胞的分化及其影响因素[J].生物物理学报，2012(2):93-111.
[14]	Kue CS, Lim HX, Jung MY，et al. C6-ceramide in combination with transforming growth factor-beta enhances Treg cell differentiation and stable FoxP3 expression in vitro and in vivo[J]. Immunobiology，2013，218(7):952-959.
[15]	Suzuki Y, Orellana MA, Schreiber RD，et al. Interferon-gamma：the major mediator of resistance against Toxoplasma gondii[J]. Science，1988，240(4851):516-518.
[16]	Garlet G, Martins W, Ferreira B，et al. Patterns of chemokines and chemokine receptors expression in different forms of human periodontal disease[J]. J Periodontal Res，2003，38(2):210-217.
[17]	Graves DT, Cochran D. The contribution of interleukin-1 and tumor necrosis factor to periodontal tissue destruction[J]. J Periodontol，2003，74(3):391-401.
[18]	Isaza-Guzmán DM, Cardona-Vélez N, Gaviria-Correa DE，et al. Association study between salivary levels of interferon（IFN）-gamma，interleukin（IL）-17，IL-21，and IL-22 with chronic periodontitis[J]. Arch Oral Biol，2015，60(1):91-99.
[19]	Graves DT, Fine D, Teng YT，et al. The use of rodent models to investigate host-bacteria interactions related to periodontal diseases[J]. J Clin Periodontol，2008，35(2):89-105.
[20]	Repeke CE, Ferreira SB Jr, Claudino M，et al. Evidences of the cooperative role of the chemokines CCL3，CCL4 and CCL5 and its receptors CCR1+ and CCR5+ in RANKL+ cell migration throughout experimental periodontitis in mice[J]. BONE，2010，46(4):1122-1130.
[21]	任莉荣，徐永清.破骨细胞分化机制的研究进展[J].中国骨质疏松杂志，2015，21(12):1522-1525,1528.
[22]	Brunetti G, Colucci S, Pignataro P，et al. T cells support osteoclastogenesis in an in vitro model derived prom human periodontitis patients[J]. J Periodontol，2005，76(10):1675-1680.
[23]	Mathieu C, Beltra J, Charpentier T，et al. IL-2 and IL-15 regulate CD8+ memory T-cell differentiation but are dispensable for protective recall responses[J]. Eur J Immunol，2015，45(12):3324-3338.
[24]	Orozco A, Gemmell E, Bickel M，et al. Interleukin-1beta，interleukin-12 and interleukin-18 levels in gingival fluid and serum of patients with gingivitis and periodontitis[J]. Oral Microbiol Immunol，2006，21(4):256-260.
[25]	Takatsu K. Interleukin-5 and IL-5 receptor in health and diseases[J]. Proc Jap Acad Ser B Phys Biol Sci，2011，87(8):463-485.
[26]	Wang S, Gao X, Shen G，et al. Interleukin-10 deficiency impairs regulatory T cell-derived neuropilin-1 functions and promotes Th1 and Th17 immunity[J]. Sci Rep，2016(6):24249.
[27]	Gemmell E, Seymour GJ. Immunoregulatory control of Th1/Th2 cytokine profiles in periodontal disease[J]. Periodontol 2000，2004(35):21-41.
[28]	Robati M, Ranjbari A, Ghafourian Boroujerdnia M，et al. Detection of IL-4，IL-6 and IL-12 serum levels in generalized aggressive periodontitis[J]. Iran J Immunol，2011，8(3):170-175.
[29]	Kawai T, Matsuyama T, Hosokawa Y，et al. B and T lymphocytes are the primary sources of RANKL in the bone resorptive lesion of periodontal disease[J]. Am J Pathol，2006，169(3):987-998.
[30]	Koutouzis T, Haber D, Shaddox L，et al. Autoreactivity of serum immunoglobulin to periodontal tissue components：a pilot study[J]. J Periodontol，2009，80(4):625-633.
[31]	Nurieva R, Yang XO, Martinez G，et al. Essential autocrine regulation by IL-21 in the generation of inflammatory T cells[J]. Nature，2007，448(7152):480-483.
[32]	Witowski J, Pawlaczyk K, Breborowicz A，et al. IL-17 stimulates intraperitoneal neutrophil infiltration through the release of GRO alpha chemokine from mesothelial cells[J]. J Immunol，2000，165(10):5814-5821.
[33]	许丽华，许尧生，杨冬茹. Th17细胞及相关细胞因子与牙周炎发生发展的免疫病理学机制[J].现代口腔医学杂志，2016，30(5):296-299.
[34]	Ohyama H, Kato-Kogoe N, Kuhara A，et al. The involvement of IL-23 and the Th17 pathway in periodontitis[J]. J Dent Res，2009，88(7):633-638.
[35]	Schenkein HA, Koertge TE, Brooks CN，et al. IL-17 in sera from patients with aggressive periodontitis[J]. J Dent Res，2010，89(9):943-947.
[36]	Fu Q, Zhang L, Duan L，et al. Correlation of chronic periodontitis in tropical area and IFN-gamma，IL-10，IL-17 levels[J]. Asian Pac J Trop Med，2013，6(6):489-492.
[37]	Cheng W, Hughes FJ, Taams LS. The presence，function and regulation of IL-17 and Th17 cells in periodontitis[J]. J Clin Periodontol，2014，41(6):541-549.
[38]	Dutzan N, Gamonal J, Silva A，et al. Over-expression of forkhead box P3 and its association with receptor activator of nuclear factor-kappa B ligand，interleukin（IL）-17，IL-10 and transforming growth factor-beta during the progression of chronic periodontitis[J]. J Clin Periodontol，2009，36(5):396-403.
[39]	Iwakura Y, Ishigame H, Saijo S，et al. Functional specialization of interleukin-17 family members[J]. Immunity，2011，34(2):149-162.
[40]	Pradeep AR, Hadge P, Chowdhry S，et al. Exploring the role of Th1 cytokines：interleukin-17 and interleukin-18 in periodontal health and disease[J]. J Oral Sci，2009，51(2):261-266.
[41]	张旭，祁胜财，唐小山，等.牙周炎患者牙龈组织中IL-21表达的研究[J].临床口腔医学杂志，2016，32(6):338-341.
[42]	Dutzan N, Vernal R, Vaque JP，et al. Interleukin-21 expression and its association with proinflammatory cytokines in untreated chronic periodontitis patients[J]. J Pperiodontol，2012，83(7):948-954.
[43]	周艳，徐艳.慢性牙周炎病人基础治疗前后Th17型细胞因子及RORC的表达变化[J].牙体牙髓牙周病学杂志，2012，22(2):103-106.
[44]	Kwok SK, Cho ML, Park MK，et al. Interleukin-21 promotes osteoclastogenesis in humans with rheumatoid arthritis and in mice with collagen-induced arthritis[J]. Arthritis Rheum，2012，64(3):740-751.
[45]	赵雅静，王盼盼，王兴羽，等.实验性牙周炎大鼠牙周组织、龈沟液及外周血中IL-22的检测[J].牙体牙髓牙周病学杂志，2016，26(6):353-357,363.
[46]	Smigiel KS, Srivastava S, Stolley JM，et al. Regulatory T-cell homeostasis：steady-state maintenance and modulation during inflammation[J]. Immunol Rev，2014，259(1):40-59.
[47]	Garlet GP, Cardoso CR, Mariano FS，et al. Regulatory T cells attenuate experimental periodontitis progression in mice[J]. J Clin Periodontol，2010，37(7):591-600.
[48]	王琳源，关宁，林晓萍. Treg细胞介导的免疫应答在牙周炎小鼠中的研究[J].实用口腔医学杂志，2015，31(3):318-322.
[49]	孙文韬，束蓉，谢玉峰. Th17/Treg失衡与牙周炎的研究进展[J].口腔生物医学，2014，5(4):199-201.
[50]	王建琪，许丽华.辅助性T细胞及其平衡与牙周炎[J].国际口腔医学杂志，2015，42(2):225-230.
[51]	程万民，郑春泉. Th细胞及其分化调节[J].国际免疫学杂志，2007，30(3):167-170.
[52]	Stashenko P, Gonçalves RB, Lipkin B，et al. Th1 immune response promotes severe bone resorption caused by Porphyromonas gingivalis[J]. Am J Pathol，2007，170(1):203-213.
[53]	Tsai CC, Ku C, Ho YP，et al. Changes in gingival crevicular fluid interleukin-4 and interferon-gamma in patients with chronic periodontitis before and after periodontal initial therapy[J]. Kaohsiung J Med Sci，2007，23(1):1-7.
[54]	Mattuella LG, Campagnaro MB, Vargas AE，et al. Plasma cytokines levels in aggressive and chronic periodontitis[J]. Acta Odontol Scand，2013，71(3-4):683-688.
[55]	Shibui A, Shimura E, Nambu A，et al. Th17 cell-derived IL-17 is dispensable for B cell antibody production[J]. Cytokine，2012，59(1):108-114.
[56]	Hickman-Brecks CL, Racz JL, Meyer DM，et al. Th17 cells can provide B cell help in autoantibody induced arthritis[J]. J Autoimmun，2011，36(1):65-75.
[57]	Kleinewietfeld M, Hafler DA. The plasticity of human Treg and Th17 cells and its role in autoimmunity[J]. Semin Immunol，2013，25(4):305-312.
[58]	Karthikeyan B, Talwar, Arun KV，et al. Evaluation of transcription factor that regulates T helper 17 and regulatory T cells function in periodontal health and disease[J]. J Pharm Bioallied Sci，2015，7(Suppl 2):S672-S676.
[59]	Wang L, Guan N, Jin Y，et al. Subcutaneous vaccination with Porphyromonas gingivalis ameliorates periodontitis by modulating Th17/Treg imbalance in a murine model[J]. Int Immunopharmacol，2015，25(1):65-73.

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