Research progress on the occurrence and development of chronic kidney disease by Porphyromonas gingivalis

doi:10.3877/cma.j.issn.1674-1366.2023.05.003

Abstract

Abstract:

Chronic kidney disease (CKD) is one of the common clinical urinary diseases, and its incidence rate has been increasing in recent years, such that it has become a major public health problem in the world. Periodontitis is a highly common oral disease in the middle-aged and elderly people, which is the main cause of tooth loss in adults and closely related to the occurrence and development of various diseases. In recent researches, it has been suggested that the main pathogen of periodontitis, Porphyromonas gingivalis (P.g) , may be an important risk factor of CKD. People suffering from both periodontitis and CKD had worse kidney fucntion than those with CKD only, and the kidney function of the former could be improved by periodontal treatment. It was found in several studies that P.g played an important role in the occurrence and development of CKD in a variety of ways, including destroying the integrity of the renal epithelium, aggravating the inflammatory response and the oxidative stress damage of kidney tissue. This article systematically reviewd the relevant studies of P.g in the occurrence and development of CKD, so as to obtain a comprehensive understanding of the relationship between periodontitis and CKD as well as the related pathogenic mechanism.

Key words: Chronic kidney disease, Periodontitis, Porphyromonas gingivalis, Pathogenic mechanism

Xiaoyin Zhang, Yang Yu. Research progress on the occurrence and development of chronic kidney disease by Porphyromonas gingivalis[J]. Chinese Journal of Stomatological Research(Electronic Edition), 2023, 17(05): 328-334.

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