Abstract:
Objective To investigate the changes of periodontal clinical indexes and inflammatory indexes in patients with periodontitis before and after periodontal basic treatment.
Methods A total of 45 patients with stage Ⅱ grade B periodontitis who were treated in the Department of Stomatology, the First People′s Hospital of Kashgar from January 2019 to December 2020 were selected, and 45 age-and sex-matched healthy people in the same period were selected as the healthy group for control. The depth of probing (PD) , attachment level (AL) and bleeding index (BI) , as well as the levels of CD163, heme oxygenase-1 (HO-1) and high-sensitivity C-reactive protein (hs-CRP) were compared between the periodontitis group and the healthy group before treatment. The changes before and after treatment in the periodontal clinical indicators, as well as the levels of CD163, HO-1 and hs-CRP in the periodontitis group were examined, and the correlation between clinical indicators and inflammatory indicators in the periodontitis patients was explored. Pearson correlation test was used for correlation analysis.
Results The PD, AL and BI score of the periodontitis group were higher than those of the healthy group before treatment, and the differences were statistically significant (P<0.001) . The levels of CD163, HO-1 and hs-CRP in the periodontitis group were higher than those in the healthy people, and the differences were statistically significant (P<0.001) . Besides, CD163, HO-1, hs-CRP, PD, AL and BI gradually decreased at the three timepoints (1, 3, and 6 month) , and the difference was statistically significant (P<0.001) . The results of Pearson correlation analysis showed that the PD, AL and BI were positively correlated with the levels of CD163, HO-1 and hs-CRP before treatment and at 1, 3 and 6 months after treatment (P<0.05) .
Conclusions The periodontal clinical indexes and inflammatory indexes of patients with periodontitis were significantly improved after periodontal basic treatment. There was a positive correlation between the periodontal clinical indexes and inflammatory indexes. Inflammatory indexes can be used as the indicators when evaluating the effect of periodontal treatment.
Key words:
Periodontitis,
Periodontal basic treatment,
CD163,
C-reactive protein,
Heme oxygenase-1
Abudouxiku Nurbiya, Mijiti Mailiyemu·, Shaobing Li. Comparative study of periodontal clinical indexes and inflammatory indexes in patients with periodontitis before and after basic treatment[J]. Chinese Journal of Stomatological Research(Electronic Edition), 2022, 16(05): 302-308.