Comparative study of periodontal clinical indexes and inflammatory indexes in patients with periodontitis before and after basic treatment

doi:10.3877/cma.j.issn.1674-1366.2022.05.006

Abstract

Abstract:

Objective

To investigate the changes of periodontal clinical indexes and inflammatory indexes in patients with periodontitis before and after periodontal basic treatment.

Methods

A total of 45 patients with stage Ⅱ grade B periodontitis who were treated in the Department of Stomatology, the First People′s Hospital of Kashgar from January 2019 to December 2020 were selected, and 45 age-and sex-matched healthy people in the same period were selected as the healthy group for control. The depth of probing (PD) , attachment level (AL) and bleeding index (BI) , as well as the levels of CD163, heme oxygenase-1 (HO-1) and high-sensitivity C-reactive protein (hs-CRP) were compared between the periodontitis group and the healthy group before treatment. The changes before and after treatment in the periodontal clinical indicators, as well as the levels of CD163, HO-1 and hs-CRP in the periodontitis group were examined, and the correlation between clinical indicators and inflammatory indicators in the periodontitis patients was explored. Pearson correlation test was used for correlation analysis.

Results

The PD, AL and BI score of the periodontitis group were higher than those of the healthy group before treatment, and the differences were statistically significant (P<0.001) . The levels of CD163, HO-1 and hs-CRP in the periodontitis group were higher than those in the healthy people, and the differences were statistically significant (P<0.001) . Besides, CD163, HO-1, hs-CRP, PD, AL and BI gradually decreased at the three timepoints (1, 3, and 6 month) , and the difference was statistically significant (P<0.001) . The results of Pearson correlation analysis showed that the PD, AL and BI were positively correlated with the levels of CD163, HO-1 and hs-CRP before treatment and at 1, 3 and 6 months after treatment (P<0.05) .

Conclusions

The periodontal clinical indexes and inflammatory indexes of patients with periodontitis were significantly improved after periodontal basic treatment. There was a positive correlation between the periodontal clinical indexes and inflammatory indexes. Inflammatory indexes can be used as the indicators when evaluating the effect of periodontal treatment.

Key words: Periodontitis, Periodontal basic treatment, CD163, C-reactive protein, Heme oxygenase-1

Abudouxiku Nurbiya, Mijiti Mailiyemu·, Shaobing Li. Comparative study of periodontal clinical indexes and inflammatory indexes in patients with periodontitis before and after basic treatment[J]. Chinese Journal of Stomatological Research(Electronic Edition), 2022, 16(05): 302-308.

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References 20

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组别	例数	PD（mm）	AL（mm）	BI（分）	CD163（ng/mL）		HO-1（ng/mL）		hs-CR（ng/mL）
组别	例数	PD（mm）	AL（mm）	BI（分）	龈沟液	外周血液	龈沟液	外周血液	hs-CR（ng/mL）
牙周炎组	45	4.66 ± 1.21	4.34 ± 0.13	2.86 ± 0.62	60 ± 9	652 ± 52	4.3 ± 1.3	10.2 ± 3.6	9.7 ± 2.7
健康组	45	1.52 ± 0.25	1.71 ± 0.58	0.64 ± 0.19	30 ± 10	426 ± 42	1.0 ± 0.4	3.3 ± 0.9	6.6 ± 1.7
t值		17.970	31.287	24.208	15.844	23.907	17.465	13.457	6.919
P值		<0.001	<0.001	<0.001	<0.001	<0.001	<0.001	<0.001	<0.001

组别	例数	PD（mm）	AL（mm）	BI（分）	CD163（ng/mL）		HO-1（ng/mL）		hs-CR（ng/mL）
组别	例数	PD（mm）	AL（mm）	BI（分）	龈沟液	外周血液	龈沟液	外周血液	hs-CR（ng/mL）
牙周炎组	45	4.66 ± 1.21	4.34 ± 0.13	2.86 ± 0.62	60 ± 9	652 ± 52	4.3 ± 1.3	10.2 ± 3.6	9.7 ± 2.7
健康组	45	1.52 ± 0.25	1.71 ± 0.58	0.64 ± 0.19	30 ± 10	426 ± 42	1.0 ± 0.4	3.3 ± 0.9	6.6 ± 1.7
t值		17.970	31.287	24.208	15.844	23.907	17.465	13.457	6.919
P值		<0.001	<0.001	<0.001	<0.001	<0.001	<0.001	<0.001	<0.001

时间点	PD（mm）	AL（mm）	BI（分）	CD163（ng/mL）		HO-1（ng/mL）		hs-CRP（ng/mL）
时间点	PD（mm）	AL（mm）	BI（分）	龈沟液	外周血中	龈沟液	外周血中	hs-CRP（ng/mL）
治疗前	4.97 ± 0.54	3.88 ± 0.13	2.86 ± 0.62	60 ± 9	652 ± 52	4.3 ± 1.3	10.2 ± 3.6	9.7 ± 1.9
治疗后1个月	2.23 ± 0.32^ab	3.49 ± 0.77^ab	1.75 ± 0.41^ab	47 ± 9^ab	511 ± 70^ab	1.8 ± 0.6^ab	6.5 ± 1.3^ab	8.4 ± 0.9^b
治疗后3个月	1.96 ± 0.40^abc	3.05 ± 0.62^abc	1.03 ± 0.33^abc	40 ± 10^abc	457±79^abc	1.5 ± 0.4^abc	5.9 ± 1.0^abc	8.0 ± 0.8^abc
治疗后6个月	1.78 ± 0.31^abcd	2.92 ± 0.68^abcd	0.68 ± 0.12^abcd	35 ± 10^abcd	427 ± 69^abcd	1.3 ± 0.4^abcd	4.2 ± 1.2^abcd	7.2 ± 0.6^abcd
F值	522.581	18.918	185.832	59.87	82.691	143.881	65.712	29.725
P值	<0.001	<0.001	<0.001	<0.001	<0.001	<0.001	<0.001	<0.001

时间点	PD（mm）	AL（mm）	BI（分）	CD163（ng/mL）		HO-1（ng/mL）		hs-CRP（ng/mL）
时间点	PD（mm）	AL（mm）	BI（分）	龈沟液	外周血中	龈沟液	外周血中	hs-CRP（ng/mL）
治疗前	4.97 ± 0.54	3.88 ± 0.13	2.86 ± 0.62	60 ± 9	652 ± 52	4.3 ± 1.3	10.2 ± 3.6	9.7 ± 1.9
治疗后1个月	2.23 ± 0.32^ab	3.49 ± 0.77^ab	1.75 ± 0.41^ab	47 ± 9^ab	511 ± 70^ab	1.8 ± 0.6^ab	6.5 ± 1.3^ab	8.4 ± 0.9^b
治疗后3个月	1.96 ± 0.40^abc	3.05 ± 0.62^abc	1.03 ± 0.33^abc	40 ± 10^abc	457±79^abc	1.5 ± 0.4^abc	5.9 ± 1.0^abc	8.0 ± 0.8^abc
治疗后6个月	1.78 ± 0.31^abcd	2.92 ± 0.68^abcd	0.68 ± 0.12^abcd	35 ± 10^abcd	427 ± 69^abcd	1.3 ± 0.4^abcd	4.2 ± 1.2^abcd	7.2 ± 0.6^abcd
F值	522.581	18.918	185.832	59.87	82.691	143.881	65.712	29.725
P值	<0.001	<0.001	<0.001	<0.001	<0.001	<0.001	<0.001	<0.001

变量		龈沟液中CD163水平		外周血液中CD163		水平龈沟液中HO-1水平		外周血液中HO-1水平		hs-CRP
变量		r值	P值	r值	P值	r值	P值	r值	P值	r值	P值
治疗前
	PD	0.526	0.000	0.521	0.000	0.486	0.001	0.476	0.001	0.632	0.000
	AL	0.659	0.000	0.598	0.000	0.511	0.000	0.489	0.001	0.526	0.000
	BI	0.624	0.000	0.611	0.000	0.536	0.000	0.488	0.001	0.489	0.001
治疗后1个月
	PD	0.628	0.000	0.514	0.000	0.459	0.001	0.436	0.002	0.476	0.001
	AL	0.648	0.002	0.562	0.000	0.491	0.000	0.489	0.002	0.508	0.003
	BI	0.403	0.005	0.396	0.005	0.403	0.005	0.362	0.010	0.432	0.001
治疗后3个月
	PD	0.635	0.000	0.623	0.000	0.427	0.002	0.416	0.005	0.483	0.001
	AL	0.630	0.000	0.541	0.001	0.483	0.005	0.475	0.010	0.496	0.005
	BI	0.532	0.000	0.503	0.000	0.426	0.002	0.367	0.010	0.503	0.000
治疗后6个月
	PD	0.438	0.002	0.433	0.002	0.412	0.005	0.403	0.005	0.431	0.002
	AL	0.624	0.001	0.536	0.000	0.477	0.005	0.466	0.010	0.488	0.001
	BI	0.463	0.001	0.426	0.005	0.389	0.005	0.343	0.020	0.462	0.001

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