The experimental study of periodontal bone defects repair with bone morphogenetic protein-nano-HAP-collagen

doi:10.3877/cma.j.issn.1674-1366.2010.02.002

Abstract

Abstract:

Objective

To observe and evaluate the effects of recombinant human bone morphogenetic protein-2 （rhBMP-2） and nano-HAP-Collagen （nHAC） on periodontal bone defects repair.

Methods

The rhBMP-2 combined with nHAC were transplanted into man-made periodontal bone defects， and the groups covered with only nHAC or with nothing were the controls. The animals were sacrificed after 8 weeks and the periodontal bone regeneration was observed histologically. Bone histomorphometry was measured.

Results

The rhBMP-2-nHAC group exhibited a large amount of new periodontal tissue. In the bone histomorphometry study，significant differences were found for the STS， DTS， MAR， TBV， TOS and TBOS values among the three groups （P ＜0.05）. The values of rhBMP-2-nHAC and nHAC group were significantly higher than that of the control group （P ＜0.05）. The difference of those value were statistically significant between rhBMP-2-nHAC and nHAC group， too （P ＜ 0.05）.

Conclusions

The rhBMP-2-nHAC compound material presents better osteoconductive and osteoinductive activity. It can be used to promote periodontal regeneration.

Key words: Periodontal bone defect, Recombinant human bone morphogenetic protein-2, Nano-HAP-Collagen, Bone histomorphometry

Yue-jing FAN, Chun-lan WANG, Ying WANG, Jing-jing CHEN. The experimental study of periodontal bone defects repair with bone morphogenetic protein-nano-HAP-collagen[J]. Chinese Journal of Stomatological Research(Electronic Edition), 2010, 4(02): 114-119.

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Figures/Tables 4

References 12

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分组	例数	STS（%）	DTS（%）	MAR（%）	TBV（%）	TOS（%）	TBOS（%）
复合材料组	6	51.33 ± 1.63	25.00 ± 1.41	2.98 ± 0.15	56.00 ± 4.94	55.67 ± 1.86	45.67 ± 2.07
单纯材料组	6	35.50 ± 2.07	14.83 ± 1.17	2.16 ± 0.10	44.50 ± 3.02	38.00 ± 1.79	33.83 ± 1.94
对照组	6	16.83 ± 1.60	8.33 ± 2.07	0.55 ± 0.07	25.83 ± 1.72	21.50 ± 2.17	13.83 ± 2.40
F		563.094	166.397	714.394	114.410	462.331	337.693
P		0.000	0.000	0.000	0.000	0.000	0.000

分组	例数	STS（%）	DTS（%）	MAR（%）	TBV（%）	TOS（%）	TBOS（%）
复合材料组	6	51.33 ± 1.63	25.00 ± 1.41	2.98 ± 0.15	56.00 ± 4.94	55.67 ± 1.86	45.67 ± 2.07
单纯材料组	6	35.50 ± 2.07	14.83 ± 1.17	2.16 ± 0.10	44.50 ± 3.02	38.00 ± 1.79	33.83 ± 1.94
对照组	6	16.83 ± 1.60	8.33 ± 2.07	0.55 ± 0.07	25.83 ± 1.72	21.50 ± 2.17	13.83 ± 2.40
F		563.094	166.397	714.394	114.410	462.331	337.693
P		0.000	0.000	0.000	0.000	0.000	0.000

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