Exploration on the mechanism of interaction between periodontitis and hyperuricemia based on TLR4/NF-κB signaling pathway

doi:10.3877/cma.j.issn.1674-1366.2021.01.010

Abstract

Abstract:

Periodontitis is an infectious disease with plaque as the initiating factor. Hyperuricemia is a chronic low-grade inflammatory disease, mainly due to purine metabolic disorders. Studies have shown a correlation between periodontitis and hyperuricemia in clinical manifestations and pathogenesis. Both of them could increase the expression of inflammatory factors in peripheral blood and make the whole body in micro-inflammation. At present, the clinical treatment strategy for patients with hyperuricemia and periodontitis needs to be improved. Based on the TLR4/NF-κB pathway, this article explores the mechanism of the interaction between periodontitis and hyperuricemia in order to provide new ideas for the treatment of patients with periodontitis and hyperuricemia.

Key words: Periodontitis, Hyperuricemia, Toll-like receptor 4, Nuclear transcription factor-kappa B

Zhuling Guo, Han Tang, Miao Huang, Jingping Li. Exploration on the mechanism of interaction between periodontitis and hyperuricemia based on TLR4/NF-κB signaling pathway[J]. Chinese Journal of Stomatological Research(Electronic Edition), 2021, 15(01): 58-62.

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