| [1] |
Liu J， Ruan J， Weir MD，et al. Periodontal bone-ligament-cementum regeneration via scaffolds and stem cells[J]. Cells， 2019， 8（6）：537. DOI： 10.3390/cells8060537.
|
| [2] |
Ni C， Zhou J， Kong N，et al. Gold nanoparticles modulate the crosstalk between macrophages and periodontal ligament cells for periodontitis treatment[J]. Biomaterials， 2019， 206：115-132. DOI： 10.1016/j.biomaterials.2019.03.039.
|
| [3] |
Elango J， Selvaganapathy PR， Lazzari G，et al. Biomimetic collagen-sodium alginate-titanium oxide（TiO 2）3D matrix supports differentiated periodontal ligament fibroblasts growth for periodontal tissue regeneration[J]. Int J Biol Macromol， 2020， 163：9-18. DOI： 10.1016/j.ijbiomac.2020.06.173.
|
| [4] |
|
| [5] |
Haugen HJ， Lyngstadaas SP， Rossi F，et al. Bone grafts：Which is the ideal biomaterial？[J]. J Clin Periodontol， 2019， 46（Suppl 21）：92-102. DOI： 10.1111/jcpe.13058.
|
| [6] |
Mckenna GJ， Gjengedal H， Harkin J，et al. Effect of autogenous bone graft site on dental implant survival and donor site complications：A systematic review and Meta-analysis[J]. J Evid Based Dent Pract， 2022， 22（3）：101731. DOI： 10.1016/j.jebdp.2022.101731.
|
| [7] |
Alshujaa B， Talmac AC， Altindal D，et al. Clinical and radiographic evaluation of the use of PRF，CGF，and autogenous bone in the treatment of periodontal intrabony defects：Treatment of periodontal defect by using autologous products[J]. J Periodontol， 2024， 95（8）：729-739. DOI： 10.1002/JPER.23-0481.
|
| [8] |
Moukrioti J， Al-Nawas B， Kreisler M. Evaluation of the split bone technique for lateral ridge augmentation：A retrospective case-control study[J]. Int J Oral Maxillofac Implants， 2019， 34（5）：1152-1160. DOI： 10.11607/jomi.7470.
|
| [9] |
Kim YK， Kim SG， Yun PY，et al. Autogenous teeth used for bone grafting：A comparison with traditional grafting materials [J]. Oral Surg Oral Med Oral Pathol Oral Radiol， 2014， 117（1）：e39-e45. DOI： 10.1016/j.oooo.2012.04.018.
|
| [10] |
Santos A， Botelho J， Machado V，et al. Autogenous mineralized dentin versus xenograft granules in ridge preservation for delayed implantation in post-extraction sites：A randomized controlled clinical trial with an 18 months follow-up[J]. Clin Oral Implants Res， 2021， 32（8）：905-915. DOI： 10.1111/clr.13765.
|
| [11] |
Zhang R， Ruangsawasdi N， Pumpaluk P，et al. Bone regeneration property of tooth-derived bone substitute prepared chairside for periodontal bone defects：An experimental study[J]. BMC Oral Health， 2023， 23（1）：863. DOI： 10.1186/s12903-023-03582-y.
|
| [12] |
Schwarz F， Golubovic V， Becker K，et al. Extracted tooth roots used for lateral alveolar ridge augmentation：A proof-of-concept study[J]. J Clin Periodontol， 2016， 43（4）：345-353. DOI： 10.1111/jcpe.12481.
|
| [13] |
Spin-Neto R， Stavropoulos A， Coletti FL，et al. Graft incorporation and implant osseointegration following the use of autologous and fresh-frozen allogeneic block bone grafts for lateral ridge augmentation[J]. Clin Oral Implants Res， 2014， 25（2）：226-233. DOI： 10.1111/clr.12107.
|
| [14] |
Dias RR， Sehn FP， de Santana ST，et al. Corticocancellous fresh-frozen allograft bone blocks for augmenting atrophied posterior mandibles in humans[J]. Clin Oral Implants Res， 2016， 27（1）：39-46. DOI： 10.1111/clr.12509.
|
| [15] |
Kothiwale S， Bhimani R， Kaderi M，et al. Comparative study of DFDBA and FDBA block grafts in combination with chorion membrane for the treatment of periodontal intra-bony defects at 12 months post surgery[J]. Cell Tissue Bank， 2019. DOI： 10.1007/s10561-018-09744-5.
|
| [16] |
Kungvarnchaikul I， Subbalekha K， Sindhavajiva PR，et al. Deproteinized bovine bone and freeze-dried bone allograft in sinus floor augmentation：A randomized controlled trial[J]. Clin Implant Dent Relat Res， 2023， 25（2）：343-351. DOI： 10.1111/cid.13179.
|
| [17] |
Alshoiby MM， Fawzy El-Sayed KM， Elbattawy W，et al. Injectable platelet-rich fibrin with demineralized freeze-dried bone allograft compared to demineralized freeze-dried bone allograft in intrabony defects of patients with stage-Ⅲ periodontitis：A randomized controlled clinical trial[J]. Clin Oral Investig， 2023， 27（7）：3457-3467. DOI： 10.1007/s00784-023-04954-y.
|
| [18] |
Borg TD， Mealey BL. Histologic healing following tooth extraction with ridge preservation using mineralized versus combined mineralized-demineralized freeze-dried bone allograft：A randomized controlled clinical trial[J]. J Periodontol， 2015， 86（3）：348-355. DOI： 10.1902/jop.2014.140483.
|
| [19] |
Kim H， Han HS， Ghanaati S，et al. Alveolar ridge preservation using a collagenated xenograft：A randomized clinical trial[J]. Int Dent J， 2025， 75（2）：1155-1164. DOI： 10.1016/j.identj.2024.07.015.
|
| [20] |
Oh S， Chung SH， Han JY. Periodontal regenerative therapy in endo-periodontal lesions：A retrospective study over 5 years[J]. J Periodontal Implant Sci， 2019， 49（2）：90-104. DOI： 10.5051/jpis.2019.49.2.90.
|
| [21] |
Lee JH， Jeong SN. Long-term stability of adjunctive use of enamel matrix protein derivative on porcine-derived xenograft for the treatment of one-wall intrabony defects：A 4-year extended follow-up of a randomized controlled trial[J]. J Periodontol， 2022， 93（2）：229-236. DOI： 10.1002/JPER.21-0254.
|
| [22] |
Kim CS， Choi SH， Cho KS，et al. Periodontal healing in one- wall intra-bony defects in dogs following implantation of autogenous bone or a coral-derived biomaterial[J]. J Clin Periodontol， 2005， 32（6）：583-589. DOI： 10.1111/j.1600-051X.2005.00729.x.
|
| [23] |
Bista S， Adhikari K， Baniya BK. Comparative evaluation of hydroxyapatite bone alloplast with combination bone alloplast （hydroxyapatitie and β-tricalcium phosphate）in Grade Ⅱ mandibular furcation involvements[J]. J Nepal Health Res Counc， 2022， 20（2）：510-516. DOI： 10.33314/jnhrc.v20i02.3796.
|
| [24] |
Dewi AH， Ana ID. The use of hydroxyapatite bone substitute grafting for alveolar ridge preservation，sinus augmentation，and periodontal bone defect：A systematic review[J]. Heliyon， 2018， 4（10）：e00884. DOI： 10.1016/j.heliyon.2018.e00884.
|
| [25] |
Liu CC， Solderer A， Heumann C，et al. Tricalcium phosphate （-containing）biomaterials in the treatment of periodontal infra-bony defects：A systematic review and Meta-analysis[J]. J Dent， 2021， 114：103812. DOI： 10.1016/j.jdent.2021.103812.
|
| [26] |
Klimecs V， Grishulonoks A， Salma I，et al. Bone loss around dental implants 5 years after implantation of biphasic calcium phosphate（HAp/βTCP）granules[J]. J Healthc Eng， 2018：4804902. DOI： 10.1155/2018/4804902.
|
| [27] |
Rattanpornsompong K， Rattanaprukskul K， Prachanukoon S，et al. Influence of alloplastic materials，biologics，and their combinations，along with defect characteristics，on short-term intrabony defect surgical treatment outcomes：A systematic review and network meta-analysis[J]. BMC Oral Health， 2025， 25（1）：413. DOI： 10.1186/s12903-025-05782-0.
|
| [28] |
Fernandez de Grado G， Keller L， Idoux-Gillet Y，et al. Bone substitutes：A review of their characteristics，clinical use，and perspectives for large bone defects management[J]. J Tissue Eng， 2018， 9：2041731418776819. DOI： 10.1177/2041731418776819.
|
| [29] |
Mohammed AA， Elsherbini AM， Ibrahim FM，et al. Biological effect of the nanocrystalline calcium sulfate bone graft in the periodontal regeneration[J]. J Oral Biol Craniofac Res， 2021， 11（1）：47-52. DOI： 10.1016/j.jobcr.2020.10.012.
|
| [30] |
Pal PC， Bali A， Boyapati R，et al. Regenerative potential of biphasic calcium phosphate and enamel matrix derivatives in the treatment of isolated interproximal intrabony defects：A randomized controlled trial[J]. J Yeungnam Med Sci， 2022， 39（4）：322-331. DOI： 10.12701/jyms.2022.00325.
|
| [31] |
Cannillo V， Salvatori R， Bergamini S，et al. Bioactive glasses in periodontal regeneration：Existing strategies and future prospects—A literature review[J]. Materials（Basel）， 2022， 15（6）：2194. DOI： 10.3390/ma15062194.
|
| [32] |
Saleem M， Pisani F， Zahid FM，et al. Adjunctive platelet-rich plasma（PRP）in infrabony regenerative treatment：A systematic review and RCT′s Meta-analysis[J]. Stem Cells Int， 2018：9594235. DOI： 10.1155/2018/9594235.
|
| [33] |
Pham TAV. Intrabony defect treatment with platelet-rich fibrin，guided tissue regeneration and open-flap debridement：A randomized controlled trial[J]. J Evid Based Dent Pract， 2021， 21（3）：101545. DOI： 10.1016/j.jebdp.2021.101545.
|
| [34] |
Xu Y， Qiu J， Sun Q，et al. One-year results evaluating the effects of concentrated growth factors on the healing of intrabony defects treated with or without bone substitute in chronic periodontitis[J]. Med Sci Monit， 2019， 25：4384-4389. DOI： 10.12659/MSM.917025.
|
| [35] |
Rochira A， Siculella L， Damiano F，et al. Concentrated growth factors（CGF）induce osteogenic differentiation in human bone marrow stem cells[J]. Biology（Basel）， 2020， 9（11）：370. DOI： 10.3390/biology9110370.
|
| [36] |
Tavelli L， Chen CJ， Barootchi S，et al. Efficacy of biologics for the treatment of periodontal infrabony defects：An American Academy of Periodontology best evidence systematic review and network Meta-analysis[J]. J Periodontol， 2022， 93（12）：1803-1826. DOI： 10.1002/JPER.22-0120.
|
| [37] |
Khehra A， Chen CY， Kim DM. The long-term success of periodontal regeneration：A 10-year follow-up case report[J]. Quintessence Int， 2023， 54（10）：802-807. DOI： 10.3290/j.qi.b4240197.
|
| [38] |
Li F， Yu F， Xu X，et al. Evaluation of recombinant human FGF-2 and PDGF-BB in periodontal regeneration：A systematic review and Meta-analysis[J]. Sci Rep， 2017， 7（1）：65. DOI： 10.1038/s41598-017-00113-y.
|
| [39] |
Pranathi V， Koduganti RR， Muthyala S，et al. Evaluation of biomaterials in periodontal regeneration：A literature review[J]. Cureus， 2024， 16（12）：e75618. DOI： 10.7759/cureus.75618.
|
| [40] |
Lee E， Moy A， Nguyen T，et al. The effect of bone morphogenetic protein-2（BMP-2）on volumetric and histometric outcomes for peri-implant defects in the animal model：A systematic review and Meta-analysis[J]. Int J Oral Maxillofac Implants， 2023， 38（4）：651-666. DOI： 10.11607/jomi.10027.
|
| [41] |
Freitas RMD， Spin-Neto R， Marcantonio Junior E，et al. Alveolar ridge and maxillary sinus augmentation using rhBMP-2：A systematic review[J]. Clin Implant Dent Relat Res， 2015， 17 （Suppl 1）：e192-e201. DOI： 10.1111/cid.12156.
|
| [42] |
Kao DWK，Kubota A，Nevins M，et al. The negative effect of combining rhBMP-2 and Bio-Oss on bone formation for maxillary sinus augmentation[J]. Int J Periodontics Restorative Dent，2012，32（1）：61-67.
|
| [43] |
Kang W， Liang Q， Du L，et al. Sequential application of bFGF and BMP-2 facilitates osteogenic differentiation of human periodontal ligament stem cells[J]. J Periodontal Res， 2019， 54（4）：424-434. DOI： 10.1111/jre.12644.
|
| [44] |
Yoshinuma N， Koshi R， Kawamoto K，et al. Periodontal regeneration with 0.3% basic fibroblast growth factor（FGF-2）for a patient with aggressive periodontitis：A case report[J]. J Oral Sci， 2016， 58（1）：137-140. DOI： 10.2334/josnusd.58.137.
|
| [45] |
Rambhia KJ， Sun H， Feng K，et al. Nanofibrous 3D scaffolds capable of individually controlled BMP and FGF release for the regulation of bone regeneration[J]. Acta Biomater， 2024， 190：50-63. DOI： 10.1016/j.actbio.2024.10.044.
|
| [46] |
Matsuura T， Mikami R， Mizutani K，et al. Assessment of bone defect morphology for the adjunctive use of bone grafting combined with enamel matrix derivative：A 3-year cohort study [J]. J Periodontol， 2024， 95（9）：809-820. DOI： 10.1002/JPER.23-0538.
|
| [47] |
Fan L， Wu D. Enamel matrix derivatives for periodontal regeneration：Recent developments and future perspectives[J]. J Healthc Eng， 2022：8661690. DOI： 10.1155/2022/8661690.
|
| [48] |
Apicella A， Heunemann P， Dejace L，et al. Scaffold requirements for periodontal regeneration with enamel matrix derivative proteins[J]. Colloids Surf B Biointerfaces， 2017， 156：221-226. DOI： 10.1016/j.colsurfb.2017.05.013.
|
| [49] |
Wang CZ， Wang YH， Lin CW，et al. Combination of a bioceramic scaffold and simvastatin nanoparticles as a synthetic alternative to autologous bone grafting[J]. Int J Mol Sci， 2018， 19（12）：4099. DOI： 10.3390/ijms19124099.
|
| [50] |
Gautam K， Kapoor A， Mathur S，et al. Comparative evaluation of autogenous bone graft and autologous platelet-rich fibrin with and without 1.2 mg in situ rosuvastatin gel in the surgical treatment of intrabony defect in chronic periodontitis patients [J]. Contemp Clin Dent， 2022， 13（1）：69-77. DOI： 10.4103/ccd.ccd_740_20.
|
| [51] |
Swami RK， Kolte AP， Kolte RA. Clinico-radiographic comparative evaluation of 1% metformin gel plus platelet-rich fibrin over platelet-rich fibrin alone in the treatment of Grade Ⅱ furcation defects：A randomized controlled double-blind clinical trial[J]. J Periodontol， 2022， 93（5）：644-655. DOI： 10.1002/JPER.21-0233.
|
| [52] |
Pradeep AR， Rao NS， Naik SB，et al. Efficacy of varying concentrations of subgingivally delivered metformin in the treatment of chronic periodontitis：A randomized controlled clinical trial[J]. J Periodontol， 2013， 84（2）：212-220. DOI： 10.1902/jop.2012.120025.
|
| [53] |
Bashutski JD， Eber RM， Kinney JS，et al. Teriparatide and osseous regeneration in the oral cavity[J]. N Engl J Med， 2010， 363（25）：2396-2405. DOI： 10.1056/NEJMoa1005361.
|
| [54] |
Tinto M， Sartori M， Pizzi I，et al. Melatonin as host modulating agent supporting nonsurgical periodontal therapy in patients affected by untreated severe periodontitis：A preliminary randomized，triple-blind，placebo-controlled study[J]. J Periodontal Res， 2020， 55（1）：61-67. DOI： 10.1111/jre.12686.
|
| [55] |
Gonde NP， Rathod SR， Kolte AP. Comparative evaluation of 1% melatonin gel in the treatment of intrabony defect：A randomized controlled clinical trial[J]. J Periodontol， 2022， 93（12）：1878-1888. DOI： 10.1002/JPER.21-0515.
|
| [56] |
Dhande SK， Rathod SR， Kolte AP，et al. Clinicoradiographic comparative evaluation of 1% melatonin gel plus platelet-rich fibrin over platelet-rich fibrin alone in treatment of Grade Ⅱ furcation defects：A randomized controlled double-blind clinical trial[J]. J Periodontol， 2024， 95（8）：707-717. DOI： 10.1002/JPER.23-0282.
|
| [57] |
Chambrone L，Avila-Ortiz G，Valenzuela FSG. Tissues：Critical issues in periodontal and implant-related plastic and reconstructive surgery[M]. 2022.
URL
|
| [58] |
Avila-Ortiz G， Ambruster J， Barootchi S，et al. American Academy of Periodontology best evidence consensus statement on the use of biologics in clinical practice[J]. J Periodontol， 2022， 93（12）：1763-1770. DOI： 10.1002/JPER.23-0282.
|
| [59] |
Miron RJ， Moraschini V， Estrin N，et al. Autogenous platelet concentrates for treatment of intrabony defects：A systematic review with Meta-analysis[J]. Periodontol 2000， 2025，97（1）：153-190. DOI： 10.1111/prd.12598.
|
| [60] |
Fukuba S， Okada M， Nohara K，et al. Alloplastic bone substitutes for periodontal and bone regeneration in dentistry：Current status and prospects[J]. Materials（Basel）， 2021， 14（5）：1096. DOI： 10.3390/ma14051096.
|
| [61] |
Lee JY， Na HJ， Kim HM，et al. Comparative study of rhPDGF-BB plus equine-derived bone matrix versus rhPDGF-BB plus β-TCP in the treatment of periodontal defects[J]. Int J Periodontics Restorative Dent， 2017， 37（6）：825-832. DOI： 10.11607/prd.3401.
|
| [62] |
Deng Y， Liang Y， Liu X. Biomaterials for periodontal regeneration [J]. Dent Clin North Am， 2022， 66（4）：659-672. DOI： 10.1016/j.cden.2022.05.011.
|
| [63] |
Aytac Z， Dubey N， Daghrery A，et al. Innovations in craniofacial bone and periodontal tissue engineering：From electrospinning to converged biofabrication[J]. Int Mater Rev， 2022， 67（4）：347-384. DOI： 10.1080/09506608.2021.1946236.
|
| [64] |
Wang W， Zhang G， Wang Y，et al. An injectable and thermosensitive hydrogel with nano-aided NIR-Ⅱ phototherapeutic and chemical effects for periodontal antibacteria and bone regeneration[J]. J Nanobiotechnology， 2023， 21（1）：367. DOI： 10.1186/s12951-023-02124-6.
|