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中华口腔医学研究杂志(电子版)

中华口腔医学研究杂志(电子版) ›› 2024, Vol. 18 ›› Issue (02) : 117 -122. doi: 10.3877/cma.j.issn.1674-1366.2024.02.007

综述

槲皮素防治口腔疾病的研究进展
罗远杰1, 杨靖梅1, 孟姝1, 敖逸博1, 申道南1,†()   
  1. 1. 口腔疾病防治全国重点实验室，国家口腔医学中心，国家口腔疾病临床医学研究中心，口腔医学+前沿医学创新中心，四川大学华西口腔医院，成都　610041
  • 收稿日期:2023-10-08 出版日期:2024-04-01
  • 通信作者: 申道南

Progress of research on quercetin against oral diseases

Yuanjie Luo1, Jingmei Yang1, Shu Meng1, Yibo Ao1, Daonan Shen1,†()   

  1. 1. State Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases, Frontier Innovation Center for Dental Medicine Plus, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China
  • Received:2023-10-08 Published:2024-04-01
  • Corresponding author: Daonan Shen
  • Supported by:
    Sichuan University Graduate Education Innovation Reform Project(GSALK2021029)
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引用本文：

罗远杰, 杨靖梅, 孟姝, 敖逸博, 申道南. 槲皮素防治口腔疾病的研究进展[J]. 中华口腔医学研究杂志(电子版), 2024, 18(02): 117-122.

Yuanjie Luo, Jingmei Yang, Shu Meng, Yibo Ao, Daonan Shen. Progress of research on quercetin against oral diseases[J]. Chinese Journal of Stomatological Research(Electronic Edition), 2024, 18(02): 117-122.

槲皮素是一种安全易得的天然多酚类化合物。研究发现，槲皮素通过多种机制展现出显著的抗氧化、抗炎、抗菌和调节凋亡的作用，作用机制的多样性和安全性使其能够广泛应用于多领域疾病防治。大量体外和动物实验表明，槲皮素能抑制口腔癌的发生、发展，治疗口腔黏膜病、牙周疾病和龋病，表现出对口腔疾病良好的治疗效果。在神经和关节等领域已有多篇文献报道了槲皮素在临床应用上的有效性，但针对口腔疾病临床应用的报道寥寥无几。本文综述了槲皮素作为口腔疾病防治药物的特性，以及在多种口腔疾病防治研究中的应用和作用机制，以期促进槲皮素在口腔疾病防治中的临床应用，为口腔疾病防治提供一种安全可靠的选择。

关键词: 槲皮素, 细胞凋亡, 口腔肿瘤, 口腔黏膜病, 牙周炎, 龋齿

Quercetin is a safe and readily available natural polyphenolic compound. It has been found that quercetin exhibits significant antioxidant, anti-inflammatory, antibacterial, and apoptosis-regulating effects through a variety of mechanisms, and its diversity of mechanisms and safety have enabled it to be widely used in a wide range of disease prevention and treatment. Many in vitro and animal experiments have shown that quercetin can inhibit the development of oral cancer, treat oral mucosal diseases, periodontal diseases and caries, showing good therapeutic effects on oral diseases. The effectiveness of quercetin in clinical applications has been reported in several papers in many fields, such as nerves and joints, but there are only a few reports on clinical applications for oral diseases. This article reviewed the properties of quercetin as a drug for oral disease control, as well as its application and mechanism in a variety of oral disease control studies, with a view to promoting the clinical application of quercetin in oral disease control and providing a safe and reliable option for oral disease control.

Key words: Quercetin, Apoptosis, Oral neoplasms, Oral mucosal disease, Periodontitis, Dental caries
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