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中华口腔医学研究杂志(电子版) ›› 2024, Vol. 18 ›› Issue (04) : 262 -268. doi: 10.3877/cma.j.issn.1674-1366.2024.04.008

综述

母体系统性疾病对新生儿唇腭裂发生的影响
陈嘉婷1, 杜美君1, 石冰1, 黄汉尧1,†()   
  1. 1. 口腔疾病研究国家重点实验室，国家口腔疾病临床医学研究中心，四川大学华西口腔医院唇腭裂外科，成都　610041
  • 收稿日期:2024-04-24 出版日期:2024-08-01
  • 通信作者: 黄汉尧

The impact of maternal systemic diseases on the incidence of cleft lip and palate in newborns

Ka Teng Chan1, Meijun Du1, Bing Shi1, Hanyao Huang1,†()   

  1. 1. State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases and Department of Oral & Maxillofacial Surgery, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China
  • Received:2024-04-24 Published:2024-08-01
  • Corresponding author: Hanyao Huang
  • Supported by:
    National Natural Science Foundation of China(82301148); China Postdoctoral Science Foundation(2024T170605); Sichuan Postdoctoral Science Foundation(TB2022005); Research Funding from West China School/Hospital of Stomatology Sichuan University(RCDWJS2024-7); Sichuan University Higher Education Teaching Reform Research Project(SCU10379)
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引用本文：

陈嘉婷, 杜美君, 石冰, 黄汉尧. 母体系统性疾病对新生儿唇腭裂发生的影响[J]. 中华口腔医学研究杂志(电子版), 2024, 18(04): 262-268.

Ka Teng Chan, Meijun Du, Bing Shi, Hanyao Huang. The impact of maternal systemic diseases on the incidence of cleft lip and palate in newborns[J]. Chinese Journal of Stomatological Research(Electronic Edition), 2024, 18(04): 262-268.

唇腭裂是最常见的先天性缺陷之一，其病因复杂，目前被认为是遗传和环境因素共同作用的结果。唇腭裂会导致颌面发育、牙齿发育、语言、饮食和听力等方面的问题，不仅给患儿带来生理和社会心理上的影响，同时增加家庭经济负担。已有大量研究明确母体患系统性疾病与后代患唇腭裂的风险密切相关。本文将从糖尿病、高血压、肥胖和系统性红斑狼疮4种系统性疾病及与系统性疾病密切相关的牙周炎入手，综述其与唇腭裂发生的关系及其影响机制的研究进展，为孕期预防和减少唇腭裂的发生提供系统性疾病角度的临床参考依据，避免或尽量减少后代出现先天性唇腭裂的风险。

关键词: 唇裂, 腭裂, 糖尿病, 高血压, 肥胖症, 红斑狼疮，系统性, 牙周炎

Cleft lip and palate are among the most common congenital anomalies, with aetiology that is complex and currently considered to be the result of both genetic and environmental factors. This condition can lead to issues in facial and dental development, speech, nutrition, and hearing, which not only impact the physiological and socio-psychological well-being of the child but also increase the financial burden on the family. Numerous studies have established a clear association between maternal systemic diseases and the risk of offspring developing cleft lip and palate. This article reviewed the relationship and mechanisms of action between four systemic diseases—diabetes, hypertension, obesity, and systemic lupus erythematosus—as well as periodontitis, which are closely related to systemic diseases, and their association with the occurrence of cleft lip and palate. It aimed to provide a clinical reference for the prevention and reduction of the incidence of cleft lip and palate during pregnancy from the perspective of systemic diseases, thereby avoiding or minimizing the risk of congenital cleft lip and palate in offspring.

Key words: Cleft lip, Cleft palate, Diabetes mellitus, Hypertension, Obesity, Lupus erythematosus, systemic, Periodontitis
图1 母体系统性疾病与新生儿唇腭裂的关系　母体糖尿病、高血压、肥胖、系统性红斑狼疮和牙周病都可能导致新生儿患有唇腭裂的风险增加（本图使用Figdraw绘制）。
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