| ［1］ |
Takmaz SA，Uysal HY，Uysal A，et al. Bilateral extraoral，infraorbital nerve block for postoperative pain relief after cleft lip repair in pediatric patients：A randomized，double - blind controlled study［J］. Ann Plast Surg，2009，63（1）：59. DOI：10.1097/SAP.0b013e3181851b8e.
|
| ［2］ |
Feriani G，Hatanaka E，Torloni MR，et al. Infraorbital nerve block for postoperative pain following cleft lip repair in children［J］.Cochrane Database Syst Rev，2016，4（4）：CD011131.DOI：10.1002/14651858.CD011131.pub2.
|
| ［3］ |
Helgadóttir HL. Pain management practices in children after surgery［J］.J Pediatr Nurs，2000，15（5）：334-340.DOI：10.1053/jpdn.2000.6170.
|
| ［4］ |
Gu X. Biomaterials and regenerative medicine in pain management［J］. Curr Pain Headache Rep，2022，26（7）：533-541.DOI：10.1007/s11916-022-01055-5.
|
| ［5］ |
Bhansali D，Teng SL，Lee CS，et al. Nanotechnology for pain management：Current and future therapeutic interventions［J］.Nano Today，2021，39：101223. DOI：10.1016/j.nantod.2021.101223.
|
| ［6］ |
Motoc D，Turtoi NC，Vasca V，et al. Physiology of pain：General mechanisms and individual differences［J］. J Medical Aradean，2010，Ⅷ（4）：19-23.
|
| ［7］ |
Coppes OJM，Yong RJ，Kaye AD，et al. Patient and surgeryrelated predictors of acute postoperative pain［J］. Curr Pain Headache Rep，2020，24（4）：12. DOI：10.1007/s11916-020-0844-3.
|
| ［8］ |
Glare P，Aubrey KR，Myles PS. Transition from acute to chronic pain after surgery［J］. Lancet，2019，393（10180）：1537-1546.DOI：10.1016/S0140-6736（19）30352-6.
|
| ［9］ |
Loeser JD，Melzack R.Pain：An overview［J］.Lancet，1999，353（9164）：1607-1609.DOI：10.1016/S0140-6736（99）01311-2.
|
| ［10］ |
Basbaum AI，Bautista DM，Scherrer G，et al. Cellular and molecular mechanisms of pain［J］.Cell，2009，139（2）：267-284.DOI：10.1016/j.cell.2009.09.028.
|
| ［11］ |
Chung MK，Ro JY. Peripheral glutamate receptor and transient receptor potential channel mechanisms of craniofacial muscle pain［J］.Mol Pain，2020，16：1744806920914204.DOI：10.1177/174 4806920914204.
|
| ［12］ |
易颖煜，朱亚琴.口颌面疼痛的研究进展［J/OL］.中华口腔医学研究杂志（电子版），2024，18（5）：300-306. DOI：10.3877/cma.j.issn.1674-1366.2024.05.003.
|
| ［13］ |
Reena，Bandyopadhyay K，Paul A. Postoperative analgesia for cleft lip and palate repair in children［J］. J Anaesthesiol Clin Pharmacol，2016，32（1）：5-11. DOI：10.4103/0970-9185.175 649.
|
| ［14］ |
Morzycki A，Nickel K，Newton D，et al.In search of the optimal pain management strategy for children undergoing cleft lip and palate repair：A systematic review and meta-analysis［J］. J Plast Reconstr Aesthet Surg，2022，75（11）：4221-4232.DOI：10.1016/j.bjps.2022.06.104.
|
| ［15］ |
Rehni AK，Jaggi AS，Singh N. Opioid withdrawal syndrome：Emerging concepts and novel therapeutic targets［J］. CNS Neurol Disord Drug Targets，2013，12（1）：112-125. DOI：10.2174/1871527311312010017.
|
| ［16］ |
Nour C，Ratsiu J，Singh N，et al. Analgesic effectiveness of acetaminophen for primary cleft palate repair in young children：A randomized placebo controlled trial［J］. Pediatric Anesthesia，2014，24（6）：574-581.DOI：10.1111/pan.12393.
|
| ［17］ |
Do A，Rorison E，Borucki A，et al.Opioid-free pain management after cleft lip repair［J］.Plast Reconstr Surg Glob Open，2023，11（9）：e5259.DOI：10.1097/GOX.0000000000005259.
|
| ［18］ |
Sacks GN，Makar KG，Harbaugh CM，et al. Institutional trends in opioid prescribing and utilization after primary cleft lip and palate repair［J］.Plast Reconstr Surg，2022，150（4）：847e-853e.DOI：10.1097/PRS.0000000000009498.
|
| ［19］ |
Oberhofer HM，Breslin N，Heindel H，et al. Analgesic efficacy of intraoperative nerve blocks for primary palatoplasty［J］. J Craniofac Surg，2021，32（2）：594-596. DOI：10.1097/SCS.00 00000000006829.
|
| ［20］ |
Failat Olushola A，Olutayo J，Olawale Olatubosun A，et al. A comparative study of bilateral infraorbital nerve block with intravenous pentazocine on the immediate postoperative pain management following cleft lip repair in infants［J］. SVOA Dentistry，2023，4（4）：145-155. DOI：10.58624/SVOADE.2023.04.0142.
|
| ［21］ |
Baumann L，Bello C，Georg FM，et al. Acute pain and development of opioid use disorder：patient risk factors［J］. Curr Pain Headache Rep，2023，27（9）：437-444. DOI：10.1007/s11916-023-01127-0.
|
| ［22］ |
Lee A，Chang BL，Yan C，et al. The reducing opioid use in children with clefts protocol： A multidisciplinary quality improvement effort to reduce perioperative opioid use in patients undergoing cleft surgery［J］.Plast Reconstr Surg，2020，145（2）：507.DOI：10.1097/PRS.0000000000006471.
|
| ［23］ |
Kamath MR，Mehandale SG，Us R. Comparative study of greater palatine nerve block and intravenous pethidine for postoperative analgesia in children undergoing palatoplasty［J］. Indian J Anaesth，2009，53（6）：654-661.
|
| ［24］ |
Bösenberg AT，Kimble FW. Infraorbital nerve block in neonates for cleft lip repair：Anatomical study and clinical application［J］.Br J Anaesth，1995，74（5）：506-508.DOI：10.1093/bja/74.5.506.
|
| ［25］ |
Salloum ML，Eberlin KR，Sethna N，et al. Combined use of infraorbital and external nasal nerve blocks for effective perioperative pain control during and after cleft lip repair［J］.Cleft Palate Craniofac J，2009，46（6）：629-635.DOI：10.1597/08-142.1.
|
| ［26］ |
Suleiman NN，Luedi MM，Joshi G，et al. Perioperative pain management for cleft palate surgery：A systematic review and procedure-specific postoperative pain management（PROSPECT）recommendations［J］. Reg Anesth Pain Med，2024，49（9）：635-641.DOI：10.1136/rapm-2023-105024.
|
| ［27］ |
Morris JL，Rosen DA，Rosen KR. Nonsteroidal anti-inflammatory agents in neonates［J］. Paediatr Drugs，2003，5（6）：385-405.DOI：10.2165/00128072-200305060-00004.
|
| ［28］ |
Carr L，Gray M，Morrow B，et al. Opioid sparing in cleft palate surgery［J］. Cleft Palate Craniofac J，2018，55（9）：1200-1204.DOI：10.1177/1055665618764516.
|
| ［29］ |
Brigham NC，Ji RR，Becker ML. Degradable polymeric vehicles for postoperative pain management［J］. Nat Commun，2021，12（1）：1367.DOI：10.1038/s41467-021-21438-3.
|
| ［30］ |
Pfaff MJ，Nolan IT，Musavi L，et al. Perioperative pain management in cleft lip and palate surgery：A systematic review and meta-analysis of randomized controlled studies［J］. Plast Reconstr Surg，2022，150（1）：145e-156e. DOI：10.1097/PRS.0000000000009231.
|
| ［31］ |
Suresh S，Voronov P. Head and neck blocks in children：An anatomical and procedural review［J］.Pediatric Anesth，2006，16（9）：910-918.DOI：10.1111/j.1460-9592.2006.02018.x.
|
| ［32］ |
Gaonkar V，Daftary SR. Comparison of preoperative infraorbital block with peri-incisional infiltration for postoperative pain relief in cleft lip surgeries［J］. Indian J Plast Surg，2004，37（2）：105-109.DOI：10.1055/s-0039-1697220.
|
| ［33］ |
Prabhu KPK，Wig J，Grewal S. Bilateral infraorbital nerve block is superior to peri-incisional infiltration for analgesia after repair of cleft lip［J］. Scand J Plastic Reconstr Surg Hand Surg，1999，33（1）：83-87.DOI：10.1080/02844319950159668.
|
| ［34］ |
Jonnavithula N，Durga P，Kulkarni DK，et al.Bilateral intra-oral，infra-orbital nerve block for postoperative analgesia following cleft lip repair in paediatric patients：Comparison of bupivacaine vs bupivacaine-pethidine combination［J］.Anaesthesia，2007，62（6）：581-585.DOI：10.1111/j.1365-2044.2007.05028.x.
|
| ［35］ |
Echaniz G，de Miguel M，Merritt G，et al.Bilateral suprazygomatic maxillary nerve blocks vs. infraorbital and palatine nerve blocks in cleft lip and palate repair：A double-blind，randomised study［J］. Eur J Anaesthesiol，2019，36（1）：40-47. DOI：10.1097/EJA.0000000000000900.
|
| ［36］ |
Han SK，Shin YW，Kim WK. Anatomy of the external nasal nerve［J］. Plast Reconstr Surg，2004，114（5）：1055-1059. DOI：10.1097/01.prs.0000135335.60575.d9.
|
| ［37］ |
Captier G，Dadure C，Leboucq N，et al. Anatomic study using three-dimensional computed tomographic scan measurement for truncal maxillary nerve blocks via the suprazygomatic route in infants［J］. J Craniofac Surg，2009，20（1）：224-228. DOI：10.1097/SCS.0b013e318191d067.
|
| ［38］ |
Mesnil M，Dadure C，Captier G，et al. A new approach for perioperative analgesia of cleft palate repair in infants：The bilateral suprazygomatic maxillary nerve block［J］. Paediatr Anaesth，2010，20（4）：343-349.DOI：10.1111/j.1460-9592.2010.03262.x.
|
| ［39］ |
Simion C，Corcoran J，Iyer A，et al. Postoperative pain control for primary cleft lip repair in infants：Is there an advantage in performing peripheral nerve blocks？［J］.Paediatr Anaesth，2008，18（11）：1060-1065.DOI：10.1111/j.1460-9592.2008.02721.x.
|
| ［40］ |
Rajamani A，Kamat V，Rajavel VP，et al. A comparison of bilateral infraorbital nerve block with intravenous fentanyl for analgesia following cleft lip repair in children［J］. Pediatr Anesth，2007，17（2）：133-139. DOI：10.1111/j.1460-9592.2006.02032.x.
|
| ［41］ |
Echaniz G，Chan V，Maynes JT，et al.Ultrasound-guided maxillary nerve block：An anatomical study using the suprazygomatic approach［J］. Can J Anaesth，2020，67（2）：186-193. DOI：10.1007/s12630-019-01481-x.
|
| ［42］ |
Anugerah A，Nguyen K，Nader A. Technical considerations for approaches to the ultrasound-guided maxillary nerve block via the pterygopalatine fossa：A literature review［J］. Reg Anesth Pain Med，2020，45（4）：301-305.DOI：10.1136/rapm-2019-100569.
|
| ［43］ |
Mireault D，Cawthorn TR，Todd AR，et al. Suprazygomatic maxillary nerve block：An ultrasound and cadaveric study to identify correct sonoanatomical landmarks［J］.J Anesth，2021，35（1）：150-153.DOI：10.1007/s00540-020-02877-6.
|
| ［44］ |
Chiono J，Raux O，Bringuier S，et al. Bilateral suprazygomatic maxillary nerve block for cleft palate repair in children：A prospective，randomized，double-blind study versus placebo［J］.Anesthesiology，2014，120（6）：1362-1369. DOI：10.1097/ALN.0000000000000171.
|
| ［45］ |
Jonnavithula N，Durga P，Madduri V，et al. Efficacy of palatal block for analgesia following palatoplasty in children with cleft palate［J］. Paediatr Anaesth，2010，20（8）：727-733. DOI：10.1111/j.1460-9592.2010.03347.x.
|
| ［46］ |
Obayah GM，Refaie A，Aboushanab O，et al. Addition of dexmedetomidine to bupivacaine for greater palatine nerve block prolongs postoperative analgesia after cleft palate repair［J］.Eur J Anaesthesiol，2010，27（3）：280-284. DOI：10.1097/EJA.0b01 3e3283347c15.
|
| ［47］ |
Nii T，Katayama Y. Biomaterial-assisted regenerative medicine［J］. Int J Mol Sci，2021，22（16）：8657. DOI：10.3390/ijms22 168657.
|
| ［48］ |
Chaurawal N，Kataria M，Kumar MV，et al. Emerging advances in nanocarriers approaches in the effective therapy of pain related disorders：Recent evidence and futuristic needs［J］. AAPS PharmSciTech，2023，24（5）：111. DOI：10.1208/s12249-023-02567-y.
|
| ［49］ |
Xu Y，Dong X，Xu H，et al. Nanomaterial-based drug delivery systems for pain treatment and relief：From the delivery of a single drug to Co - delivery of multiple therapeutics［J］.Pharmaceutics，2023，15（9）：2309. DOI：10.3390/pharmaceutics 15092309.
|
| ［50］ |
Bulbake U，Doppalapudi S，Kommineni N，et al. Liposomal formulations in clinical use： An updated review ［J］.Pharmaceutics，2017，9（2）：12. DOI：10.3390/pharmaceutics 9020012.
|
| ［51］ |
Chelly JE，Goel SK，Kearns J，et al. Nanotechnology for pain management［J］. J Clin Med，2024，13（9）：2611. DOI：10.3390/jcm13092611.
|
| ［52］ |
Hua S，Cabot PJ. Targeted nanoparticles that mimic immune cells in pain control inducing analgesic and anti-inflammatory actions：A potential novel treatment of acute and chronic pain condition［J］. Pain Physician，2013，16（3）：E199-E216. DOI：10.1007/s00234-013-1168-3.
|
| ［53］ |
Lu B，Wei L，Shi G，et al. Nanotherapeutics for alleviating anesthesia-associated complications［J］.Adv Sci（Weinh），2024，11（15）：2308241.DOI：10.1002/advs.202308241.
|
| ［54］ |
Tsai YH，Yang YN，Ho YC，et al. Drug release and antioxidant/antibacterial activities of silymarin-zein nanoparticle/bacterial cellulose nanofiber composite films［J］. Carbohydr Polym，2018，180：286-296.DOI：10.1016/j.carbpol.2017.09.100.
|
| ［55］ |
Das S，Roy P，Auddy RG，et al.Silymarin nanoparticle prevents paracetamol - induced hepatotoxicity［J］. Int J Nanomedicine，2011，6：1291-1301.DOI：10.2147/IJN.S15160.
|
| ［56］ |
Kaye AD，Armstead-Williams C，Hyatali F，et al. Exparel for postoperative pain management：A comprehensive review［J］.Curr Pain Headache Rep，2020，24（11）：73. DOI：10.1007/s11916-020-00905-4.
|
| ［57］ |
Raguram A，Banskota S，Liu DR.Therapeutic in vivo delivery of gene editing agents［J］. Cell，2022，185（15）：2806. DOI：10.1016/j.cell.2022.03.045.
|
| ［58］ |
da Silva A，Lepetre - Mouelhi S，Couvreur P. Micro - and nanocarriers for pain alleviation［J］. Adv Drug Deliv Rev，2022，187：114359.DOI：10.1016/j.addr.2022.114359.
|
| ［59］ |
Kataria S，Patel U，Yabut K，et al. Recent advances in management of neuropathic，nociceptive，and chronic pain：A narrative review with focus on nanomedicine，gene therapy，stem cell therapy，and newer therapeutic options［J］. Curr Pain Headache Rep，2024，28（5）：321-333. DOI：10.1007/s11916-024-01227-5.
|
| ［60］ |
Meunier A，Latrémolière A，Mauborgne A，et al. Attenuation of pain-related behavior in a rat model of trigeminal neuropathic pain by viral-driven enkephalin overproduction in trigeminal ganglion neurons［J］. Mol Ther，2005，11（4）：608-616. DOI：10.1016/j.ymthe.2004.12.011.
|
| ［61］ |
Wang T，Zhu X，Yi H，et al.Viral vector-mediated gene therapy for opioid use disorders［J］. Exp Neurol，2021，341：113710.DOI：10.1016/j.expneurol.2021.113710.
|
| ［62］ |
Kanda H，Kanao M，Liu S，et al. HSV vector-mediated GAD67 suppresses neuropathic pain induced by perineural HIV gp120 in rats through inhibition of ROS and Wnt5a［J］. Gene Ther，2016，23（4）：340-348.DOI：10.1038/gt.2016.3.
|
| ［63］ |
Kanao M，Kanda H，Huang W，et al. Gene transfer of glutamic acid decarboxylase 67 by herpes simplex virus vectors suppresses neuropathic pain induced by human immunodeficiency virus gp120 combined with ddC in rats［J］. Anesth Analg，2015，120（6）：1394-1404.DOI：10.1213/ANE.0000000000000729.
|
| ［64］ |
Ovsepian SV，Waxman SG. Gene therapy for chronic pain：Emerging opportunities in target-rich peripheral nociceptors［J］.Nat Rev Neurosci，2023，24（4）：252-265.DOI：10.1038/s41583-022-00673-7.
|
| ［65］ |
Vit JP，Ohara PT，Sundberg C，et al. Adenovector GAD65 gene delivery into the rat trigeminal ganglion produces orofacial analgesia［J］.Mol Pain，2009，5：42.DOI：10.1186/1744-8069-5-42.
|
| ［66］ |
Meunier A，Latrémolière A，Dominguez E，et al. Lentiviralmediated targeted NF-kappaB blockade in dorsal spinal cord glia attenuates sciatic nerve injury-induced neuropathic pain in the rat［J］. Mol Ther，2007，15（4）：687-697. DOI：10.1038/sj.mt.6300107.
|
| ［67］ |
Sun T，Luo J，Jia M，et al. Small interfering RNA-mediated knockdown of NF-κB p65 attenuates neuropathic pain following peripheral nerve injury in rats［J］. Eur J Pharmacol，2012，682（1/2/3）：79-85.DOI：10.1016/j.ejphar.2012.02.017.
|
| ［68］ |
Song Z，Zou W，Liu C，et al. Gene knockdown with lentiviral vector-mediated intrathecal RNA interference of protein kinase C gamma reverses chronic morphine tolerance in rats［J］. J Gene Med，2010，12（11）：873-880.DOI：10.1002/jgm.1514.
|
| ［69］ |
Remmel A. CRISPR-based gene therapy dampens pain in mice［J］. Nature，2021，591（7850）：359. DOI：10.1038/d41586-021-00644-5.
|
| ［70］ |
Denning S，Ng E，Wong Riff KWY. Anaesthesia for cleft lip and palate surgery［J］. BJA Educ，2021，21（10）：384-389. DOI：10.1016/j.bjae.2021.06.002.
|
| ［71］ |
Chen ZM，Gao BH，Wang LS. Effect of two different doses of nalbuphine for postoperative analgesia in children with cleft palate：A randomized controlled trial［J］. BMC Anesthesiol，2024，24（1）：22.DOI：10.1186/s12871-024-02404-0.
|
| ［72］ |
Suleiman NN，Luedi MM，Joshi G，et al. Perioperative pain management for cleft palate surgery：A systematic review and procedure-specific postoperative pain management（PROSPECT）recommendations［J］. Reg Anesth Pain Med，2023，49（9）：635.DOI：10.1136/rapm-2023-105024.
|
| ［73］ |
Aycart MA，Caterson EJ.Advances in cleft lip and palate surgery［J］. Medicina，2023，59（11）：1932. DOI：10.3390/medicina59 111932.
|
| ［74］ |
Shi Y，Zhang X，Sun Y，et al.Emergence agitation after the cleft lip or palate surgery in pediatric patients：A prospective study［J］. J Stomatol Oral Maxillofac Surg，2021，122（6）：539-543.DOI：10.1016/j.jormas.2020.11.006.
|
| ［75］ |
Eull D，Looman W，O'Conner-Von S. Transforming acute pain management in children：A concept analysis to develop a new model of nurse，child and parent partnership［J］. J Clin Nurs，2023，32（15-16）：5230-5240.DOI：10.1111/jocn.16625.
|
| ［76］ |
Goldstein LH，Berlin M，Berkovitch M，et al. Effectiveness of oral vs rectal acetaminophen：A meta-analysis［J］. Arch Pediatr Adolesc Med，2008，162（11）：1042 - 1046. DOI：10.1001/archpedi.162.11.1042.
|
| ［77］ |
Ramos RPL，Victorio DJB，Ramos GT，et al.Changes in the oral health-related quality of life in infants with cleft lip and/or palate before and after surgical treatment［J］. Cleft Palate Craniofac J，2021，59（1）：47-53.DOI：10.1177/1055665621993282.
|
| ［78］ |
Wydick B，Zahid M，Manning S，et al. The impact of cleft lip/palate and surgical intervention on adolescent life outcomes［J］.Ann Glob Health，2022，88（1）：25.DOI：10.5334/aogh.3679.
|
| ［79］ |
Montero-Orellana MJ，Fuentes-Orellana MR，Ossa-Cox M.Gaps between the indication and the home execution of massage therapy in children in the postsurgical stage of primary cheiloplasty or rhinocheiloplasty［J］. J Craniofac Surg，2023，34（6）：1690-1691.DOI：10.1097/SCS.0000000000009474.
|