Abstract:

Cleft lip and palate is one of the most common congenital anomalies. Currently，surgery remains the only effective treatment method of it. However，the pain experienced by children during the perioperative period of cleft lip and palate surgery can induce adverse emotional and physiological responses，not only affecting the normal feeding of the children，but also potentially leading to wound dehiscence due to excessive crying caused by pain. Therefore，the management of pain during the perioperative period of cleft lip and palate surgery is closely related to the final outcome of the surgical treatment. This article reviews the current research progress in pain management from the aspects of the mechanism of pain during the perioperative period of cleft lip and palate surgery，the selection of analgesic drugs，anesthesia methods，and their effects. With the development of biotherapeutic technology，the application of biomaterials in pain management also shows great potential. Thus，this article dicusses the application prospects of novel therapeutic methods based on biomaterials in the pain management during the perioperative period of cleft lip and palate surgery.

Key words: Cleft lip and palate, Perioperation, Pain, Anesthesia, Biomaterials