Abstract:

The oralome is the collection of dynamic interactions between the ecological communities of oral microorganisms living in the oral cavity and their hosts，and these microorganisms make up the complex ecosystem which is symbiotic with the human host， also known as oral microecology. The "ecological plaque hypothesis" is one of the most widely accepted hypotheses on the etiology of caries，which suggests that the microecology in the oral cavity maintains a healthy state. The oral environment changed and disturbed the normal ecological balance which pushes the symbiotic microbial community transform into a pathogenicbiofilm community， causing microecology dysbiosis and ultimately leading to the occurrence of dental caries. Thus，maintaining or restoring oral microecological balance is a significant goal in the prevention and treatment of dental caries.Emerging biomaterials and technologies such as prebiotics，antimicrobial peptides， nanoparticles， natural substances，probiotics and phages have become the hotspots in the field of caries prevention because of their unique advantages and great potential. In this article，we review above anti - caries biomaterials in dental caries prevention from the perspective of regulating oral microecological balance，providing a theoretical basis for the future research.

Key words: Dental caries, Oral microecology, Dysbiosis, Antimicrobial peptides, Nanomaterials, Phages