New advances of the mechanism of signal transducer and activator of transcription 3 in tooth development

doi:10.3877/cma.j.issn.1674-1366.2024.06.002

Abstract

Abstract:

Tooth development is a complex and precise process involving interactions between epithelial and ectomesenchymal tissues，with multiple signaling pathways and regulatory factors participating. Proper tooth development is crucial for phonation，mastication，and the overall development of the craniofacial region. Signal transducer and activator of transcription 3（STAT3），a key transcription factor，plays a critical role in processes such as cell proliferation，survival，apoptosis， angiogenesis， immune responses， and cell migration.Recent studies have highlighted the significant role of STAT3 in tooth development. This paper summarizes recent advancements in the research on STAT3 in tooth development，with a focus on its role in ameloblasts，odontoblasts，dental pulp stem cells，and cementoblast differentiation，so as to offer new perspectives and references for the diagnosis and treatment of clinical tooth development abnormalities.

Key words: Tooth dysplasia, Signal transducer and activator of transcription 3, Ameloblast, Odontoblasts, Cementoblast

Wangyu Luo, Le Zhao, Liu Yang, Xiaolei Zhang. New advances of the mechanism of signal transducer and activator of transcription 3 in tooth development[J]. Chinese Journal of Stomatological Research(Electronic Edition), 2024, 18(06): 357-361.

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