The research progress on the role of odontoblast in pulp immune response

doi:10.3877/cma.j.issn.1674-1366.2017.04.009

Abstract

Abstract:

As characteristic cells in pulp-dentin complex, the main functions of odontoblasts are the synthesis, extracellular deposition, and mineralization of collagen-rich matrix to form the dentin tissue. Recent studies have indicated that the odontoblasts may have functioned not only as dentinogenesis, but also as first cells encountered by pathogens. When encountered to pathogens invalided by caries, odontoblasts identify pathogen-associated molecular patterns via pattern recognition receptors and start immune defense response. This article reviews the histophysiological characteristics of odontoblasts and their functions in the immune response of pulpitis.

Key words: Odontoblasts, Dental pulp, Immunity, Defense mechanisms

Runsha Meng, Qiong Xu. The research progress on the role of odontoblast in pulp immune response[J]. Chinese Journal of Stomatological Research(Electronic Edition), 2017, 11(04): 238-241.

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References 49

[1]	Love RM, Jenkinson HF. Invasion of dentinal tubules by oral bacteria[J]. Crit Rev Oral Biol Med，2002，13(2):171-183.
[2]	Couve E, Osorio R, Schmachtenberg O. The amazing odontoblast：activity，autophagy，and aging[J]. J Dent Res，2013，92(9):765-772.
[3]	Veerayutthwilai O, Byers MR, Pham TT，et al. Differential regulation of immune responses by odontoblasts[J]. Oral Microbiol Immunol，2007，22(1):5-13.
[4]	Goldberg M, Farges JC, Lacerda-Pinheiro S，et al. Inflammatory and immunological aspects of dental pulp repair[J]. Pharmacol Res，2008，58(2):137-147.
[5]	Goldberg M, Lasfargues JJ. Pulpo-dentinal complex revisited[J]. J Dent，1995，23(1):15-20.
[6]	Fransson H, Petersson K, Davies JR. Effects of bacterial products on the activity of odontoblast-like cells and their formation of type 1 collagen[J]. Int Endod J，2014，47(4):397-404.
[7]	Staquet MJ, Durand SH, Colomb E，et al. Different roles of odontoblasts and fibroblasts in immunity[J]. J Dent Res，2008，87(3):256-261.
[8]	Botero TM, Shelburne CE, Holland GR，et al. TLR4 mediates LPS-induced VEGF expression in odontoblasts[J]. J Endod，2006，32(10):951-955.
[9]	Mjör IA, Sveen OB, Heyeraas KJ. Pulp-dentin biology in restorative dentistry. Part 1：normal structure and physiology[J]. Quintessence Int，2001，32(6):427-446.
[10]	Boshtam M, Asgary S, Kouhpayeh S，et al. Aptamers Against Pro- and Anti-Inflammatory Cytokines：A Review[J]. Inflammation，2017，40(1):340-349.
[11]	Schröder NW, Morath S, Alexander C，et al. Lipoteichoic acid （LTA）of Streptococcus pneumoniae and Staphylococcus aureus activates immune cells via Toll-like receptor（TLR）-2，lipopolysaccharide-binding protein（LBP），and CD14，whereas TLR-4 and MD-2 are not involved[J]. J Biol Chem，2003，278(18):15587-15594.
[12]	Baek KT, Bowman L, Millership C，et al. The Cell Wall Polymer Lipoteichoic Acid Becomes Nonessential in Staphylococcus aureus Cells Lacking the ClpX Chaperone[J]. MBio，2016，7(4):e01228-16.
[13]	Durand SH, Flacher V, Roméas A，et al. Lipoteichoic acid increases TLR and functional chemokine expression while reducing dentin formation in in vitro differentiated human odontoblasts[J]. J Immunol，2006，176(5):2880-2887.
[14]	Dommisch H, Steglich M, Eberhard J，et al. Phosphatidylinositol-3-kinase inhibitor LY 294002 blocks Streptococcus mutans-induced interleukin（IL）-6 and IL-8 gene expression in odontoblast-like cells[J]. Int Endod J，2008，41(9):763-771.
[15]	Carrouel F, Staquet M, Keller J，et al. Lipopolysaccharide-binding protein inhibits toll-like receptor 2 activation by lipoteichoic acid in human odontoblast-like cells[J]. J Endod，2013，39(8):1008-1014.
[16]	Anggård E. Nitric oxide：mediator，murderer，and medicine[J]. Lancet，1994，343(8907):1199-1206.
[17]	Lind M, Hayes A, Caprnda M，et al. Inducible nitric oxide synthase：Good or bad？[J]. Biomed Pharmacother，2017(93):370-375.
[18]	Farges JC, Bellanger A, Ducret M，et al. Human odontoblast-like cells produce nitric oxide with antibacterial activity upon TLR2 activation[J]. Front Physiol，2015(6):185.
[19]	Couble ML, Farges JC, Bleicher F，et al. Odontoblast differentiation of human dental pulp cells in explant cultures[J]. Calcif Tissue Int，2000，66(2):129-138.
[20]	Horst OV, Horst JA, Samudrala R，et al. Caries induced cytokine network in the odontoblast layer of human teeth[J]. BMC Immunol，2011(12):9.
[21]	Takeuchi O, Akira S. Pattern recognition receptors and inflammation[J]. Cell，2010，140(6):805-820.
[22]	Farges JC, Alliot-Licht B, Baudouin C，et al. Odontoblast control of dental pulp inflammation triggered by cariogenic bacteria[J]. Front Physiol，2013(4):326.
[23]	Medvedev AE. Toll-like receptor polymorphisms，inflammatory and infectious diseases，allergies，and cancer[J]. J Interferon Cytokine Res，2013，33(9):467-484.
[24]	Farges JC, Keller JF, Carrouel F，et al. Odontoblasts in the dental pulp immune response[J]. J Exp Zoo B Mol Dev Evol，2009，312B(5):425-436.
[25]	Jiang HW, Zhang W, Ren BP，et al. Expression of toll like receptor 4 in normal human odontoblasts and dental pulp tissue[J]. J Endod，2006，32(8):747-751.
[26]	Farges JC, Carrouel F, Keller JF，et al. Cytokine production by human odontoblast-like cells upon Toll-like receptor-2 engagement[J]. Immunobiology，2011，216(4):513-517.
[27]	Horst OV, Tompkins KA, Coats SR，et al. TGF-beta1 Inhibits TLR-mediated odontoblast responses to oral bacteria[J]. J Dent Res，2009，88(4):333-338.
[28]	席琼，胡巢凤. NOD样受体在炎症反应中的调控作用[J].生命科学，2010，22(5):454-458.
[29]	Lee YY, Chan CH, Hung SL，et al. Up-regulation of nucleotide-binding oligomerization domain 1 in inflamed human dental pulp[J]. J Endod，2011，37(10):1370-1375.
[30]	Lin ZM, Song Z, Qin W，et al. Expression of nucleotide-binding oligomerization domain 2 in normal human dental pulp cells and dental pulp tissues[J]. J Endod，2009，35(6):838-842.
[31]	Hosokawa Y, Hirao K, Yumoto H，et al. Functional Roles of NOD1 in Odontoblasts on Dental Pulp Innate Immunity[J]. Biomed Res Int，2016(2016):9325436.
[32]	Ting JP, Lovering RC, Alnemri ES，et al. The NLR gene family：a standard nomenclature[J]. Immunity，2008，28(3):285-287.
[33]	Song Z, Lin Z, He F，et al. NLRP3 is expressed in human dental pulp cells and tissues[J]. J Endod，2012，38(12):1592-1597.
[34]	Fukata M, Vamadevan AS, Abreu MT. Toll-like receptors （TLRs）and Nod-like receptors（NLRs）in inflammatory disorders[J]. Semin Immunol，2009，21(4):242-253.
[35]	王乐怡，吴欣怡. Toll样受体与NOD样受体在炎症中作用的研究进展[J].现代免疫学，2010，30(5):436-439.
[36]	Keller JF, Carrouel F, Staquet MJ，et al. Expression of NOD2 is increased in inflamed human dental pulps and lipoteichoic acid-stimulated odontoblast-like cells[J]. Innate Immun，2011，17(1):29-34.
[37]	Hirao K, Yumoto H, Takahashi K，et al. Roles of TLR2，TLR4，NOD2，and NOD1 in Pulp Fibroblasts[J]. J Dent Res，2009，88(8):762-767.
[38]	Mizushima N, Levine B. Autophagy in mammalian development and differentiation[J]. Nat Cell Biol，2010，12(9):823-830.
[39]	Deretic V, Saitoh T, Akira S. Autophagy in infection，inflammation and immunity[J]. Nat Rev Immunol，2013，13(10):722-737.
[40]	Virgin HW, Levine B. Autophagy genes in immunity[J]. Nat Immunol，2009，10(5):461-470.
[41]	肖孟景，李利根.自噬调控过度炎症研究进展[J].生理学报，2014，66(6):739-745.
[42]	Pei F, Lin H, Liu H，et al. Dual role of autophagy in lipopolysaccharide-induced preodontoblastic cells[J]. J Dent Res，2015，94(1):175-182.
[43]	Wang HS, Pei F, Chen Z，et al. Increased Apoptosis of Inflamed Odontoblasts Is Associated with CD47 Loss[J]. J Dent Res，2016，95(6):697-703.
[44]	Zero DT, Zandona AF, Vail MM，et al. Dental caries and pulpal disease[J]. Dent Clin North Am，2011，55(1):29-46.
[45]	Ozeki N, Yamaguchi H, Kawai R，et al. Cytokines induce MMP-3-regulated proliferation of embryonic stem cell-derived odontoblast-like cells[J]. Oral Dis，2014，20(5):505-513.
[46]	Tziafas D, Papadimitriou S. Role of exogenous TGF-beta in induction of reparative dentinogenesis in vivo[J]. Eur J Oral Sci，1998(106 Suppl 1):192-196.
[47]	Hu CC, Zhang C, Qian Q，et al. Reparative dentin formation in rat molars after direct pulp capping with growth factors[J]. J Endod，1998，24(11):744-751.
[48]	Zhang W, Walboomers XF, Jansen JA. The formation of tertiary dentin after pulp capping with a calcium phosphate cement，loaded with PLGA microparticles containing TGF-beta1[J]. J Biomed Mater Res A，2008，85(2):439-444.
[49]	Nakayama K, Hirata-Tsuchiya S, Okamoto K，et al. The Novel NF-kappaB Inhibitor，MTI-II Peptide Anti-Inflammatory Drug，Suppresses Inflammatory Responses in Odontoblast-Like Cells[J]. J Cell Biochem，2016，117(11):2552-2558.

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