Research progress of regulation of stem cell biological behavior by scaffold mechanical properties through Yes-associated protein signaling

doi:10.3877/cma.j.issn.1674-1366.2022.06.004

Abstract

Abstract:

Stem cells can sense the physical or chemical signals of the local microenvironment to regulate biological behaviors including adhesion, proliferation, differentiation, metabolism, and immunity. A common strategy of designing artificial scaffolds in tissue engineering is to simulate the mechanical properties of the microenvironment in vivo. Growing evidence suggests that Yes-associated protein (YAP) plays an important role in the process by which stem cells recognize external mechanical cues and transform the information into cellular responses. In this review, we summarized the research progress on the mechanical properties of scaffolds and the mechanism of YAP in regulating stem cell biological behavior.

Key words: Yes-associated protein, Stem cells, Scaffold, Mechanical properties, Biological behavior

Guixian Li, Hongwei Jiang, Yu Du. Research progress of regulation of stem cell biological behavior by scaffold mechanical properties through Yes-associated protein signaling[J]. Chinese Journal of Stomatological Research(Electronic Edition), 2022, 16(06): 358-363.

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References 64

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