Research progress of mitochondrial dynamics in dental mesenchymal stem cells

doi:10.3877/cma.j.issn.1674-1366.2022.06.003

Abstract

Abstract:

Dental mesenchymal stem cells (DMSCs) are derived from mammalian tooth-related tissues, which have the functions of self-renewal, multi-directional differentiation and immunomodulation. They have important research values in tissue engineering and regenerative medicine. Mitochondria, known as mitochondrial dynamics, are highly dynamic organelles that maintain their morphology through continuous division and fusion. Studies have shown that mitochondrial dynamics is a key factor in determining the fate of stem cells. The coordination of mitochondrial division and fusion is vital for cell function and stress response, while abnormal dynamic may lead to the dysfunction of stem cells. Recent studies have confirmed that DMSCs undergo specific mitochondrial dynamics in the process of proliferation, differentiation, apoptosis or senescence. This article reviewed the molecular regulation mechanism of mitochondrial dynamics, the morphological characteristics of mesenchymal stem cell mitochondria, and the role of mitochondrial dynamics in regulating DMSCs behavior in physiological and stress microenvironment.

Key words: Mesenchymal stem cells, Dental mesenchymal stem cells, Mitochondria, Mitochondrial dynamics, Stem cells fate

Luo Huang, Ailin Liang, Qimei Gong. Research progress of mitochondrial dynamics in dental mesenchymal stem cells[J]. Chinese Journal of Stomatological Research(Electronic Edition), 2022, 16(06): 352-357.

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