Endoplasmic reticulum stress in skeletal development and bone homostasis

doi:10.3877/cma.j.issn.1674-1366.2021.05.010

Abstract

Abstract:

Bone homeostasis is a process of interaction between osteoclasts and osteoblasts, with abundant extracellular matrix proteins existing in bone tissue. During protein synthesis, the increase of unfolded and misfolded proteins lead to endoplasmic reticulum stress, which induce the unfolded protein responses mediated by IRE1α, PERK and ATF6 family. Excessive stress leads to chondrodysplasia, osteoarthritis and periodontitis bone resorption. This review focuses on the role of endoplasmic reticulum stress in bone metabolism and it is of great significance for our further understanding of bone metabolism and treatment of related diseases.

Key words: Endoplasmic reticulum stress, Unfolded protein response, Apoptosis, Bone metabolism

Ruitian Lin, Zihan Li, Lisha Gu. Endoplasmic reticulum stress in skeletal development and bone homostasis[J]. Chinese Journal of Stomatological Research(Electronic Edition), 2021, 15(05): 309-313.

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