探讨增材制造Ti-6Al-4V钛合金种植体在牙缺失种植修复中的临床治疗效果。

2020年11月至2022年6月中山大学附属第五医院口腔科和广西医科大学附属口腔医院口腔种植科治疗的后牙缺失患者86例（缺失牙数87颗）。其中研究组43例（缺失牙数44颗），采用自行研制的增材制造Ti-6Al-4V钛合金种植体行种植修复；对照组43例（缺失牙数43颗），采用B & B种植体（意大利）行种植修复。对两组种植修复术后6个月内种植成功率、种植体周骨组织变化、牙龈状态和咀嚼效能进行比较分析。使用SPSS 23.0统计学软件对组间数据进行统计分析。

87颗种植牙中，研究组44颗，种植术后植体无脱落，牙龈无红肿，修复后咀嚼功能正常，种植上部修复后2例出现边缘嵴崩瓷，种植成功率95.5%；对照组43颗，种植术后2颗植体脱落，1例基台螺丝反复松动而重新修复，种植成功率93%，两组种植成功率比较差异无统计学意义（χ² = 0.237，P>0.05）；研究组种植义齿修复后无咬合干扰和食物嵌塞，咀嚼功能良好，总有效率100%；对照组1例因螺丝松动导致咀嚼功能不良，总有效率97.7%，两组间咀嚼功能比较差异无统计学意义（χ² = 0.181，P>0.05）；两组间各随访时间点种植体周围骨吸收值<0.6 mm，差异无统计学意义（t = 1.974，P>0.05）；两组种植牙修复后牙龈形态、牙龈色泽和牙龈乳头高度恢复满意度，按种植牙修复后牙龈形态恢复情况，≥1分为满意，<1分为不满意，研究组满意度为93.2%，对照组为95.3%，两组差异无统计学意义（χ² = 0.236，P>0.05）。

增材制造Ti-6Al-4V钛合金种植体在后牙缺失修复中成功率、咀嚼功能及美学效果等方面达到满意的近期临床疗效，能够满足临床应用，远期临床效果有待于进一步观察。

To explore the clinical therapeutic effect of additive manufacturing Ti-6Al-4V titanium alloy implants in dental implant restoration.

Retrospective analysis was conducted on 86 patients with posterior tooth loss treated in the Department of Stomatology, the Fifth Affiliated Hospital, Sun Yat-sen University, and the Department of Dental Implantation, the Affiliated Hospital of Guangxi Medical University from November 2020 to June 2022, with a total of 87 missing teeth. Among them, there were 43 cases in the test group, with 44 missing teeth, which were restored with Ti-6Al-4V titanium alloy implants made of self-developed additives. In contrast, another 43 cases in the control group, with 43 missing teeth, were restored with B & B implants (Italy) . The implant success rate, changes in bone tissue around the implant, gingival status, and chewing efficiency within six months after implantation were compared between the two groups with SPSS 23.0 at a significance level of 0.05.

In the test group, there was no implant loss, no redness or swelling of the gingiva, and the chewing function was normal after restoration. Two cases showed marginal bone loss, with a success rate of 95.5%. In the control group, two implants failed, and one case had a repeated loose of the abutment screw. The implant success rate was 93%, and there was no statistically significant difference in the success rate between the two groups (χ² = 0.237, P>0.05) ; The test group had no occlusal interference and food impaction after implant denture restoration, with good chewing function and a total effective rate of 100%. In the control group, one case had poor chewing function due to loose screw, with a total effective rate of 97.7%. There was no statistically significant difference in chewing function (χ² = 0.181, P>0.05) . The bone resorption around the implant was less than 0.6 mm at each follow-up time point in both the two groups, with no significant difference between them (t = 1.974, P>0.05) . Patient satisfaction with the restoration was 93.2% in the test group and 95.3% in the control group, which was not statistically different (χ² = 0.236, P>0.05) .

Additive manufacturing Ti-6Al-4V titanium alloy implant has achieved satisfactory short-term clinical outcomes in terms of success rate, chewing function and aesthetic effect in the restoration of missing posterior teeth, which can be applied clinically. However, its long-term clinical effect needs to be further observed.