Research progress of pyroptosis in diabetic periodontitis

doi:10.3877/cma.j.issn.1674-1366.2021.03.011

Abstract

Abstract:

Pyroptosis, as one of the programmed cell death, has been explored and studied in many diseases since it was named in 2001. The occurrence of it depends on Gasdermin D (GSDMD) cleavage by caspase-1/4/5/11 and mediates the release of inactive cytokines such as IL-18, IL-1β and other intracellular content. At present, the growing evidence from various studies showed that the indirect and direct role of pyroptosis in periodontitis. However, the research on the occurrence and development of pyroptosis in periodontitis is still limited. Therefore, the further research is needed. This article mainly summarizes the role of pyroptosis in diabetic periodontitis and the specific molecular mechanisms in recent years.

Key words: Pyroptosis, Caspases, Diabetes mellitus, Periodontitis, Gasdermin D

Jiao Pu, Zhongcheng Gong. Research progress of pyroptosis in diabetic periodontitis[J]. Chinese Journal of Stomatological Research(Electronic Edition), 2021, 15(03): 189-192.

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