Bone regeneration ability of PHBV/SGBG composite： an in vivo study

doi:10.3877/cma.j.issn.1674-1366.2010.03.004

Abstract

Abstract:

Objective

To study the osteogenesis efficiency of poly（3-bydroxybutyrate-co-3-bydroxyvalerate）/sol-gel bioactive glass （PHBV/SGBG） composite in vivo.

Methods

Four bone defects were made in dog bilateral tibias.PHBV/SGBG composite were embed in the defects of the experimental group， while defects with no treatment served as control.Samples were harvested at week 2， 4， 8， and 12 post-surgery.The effect of osteogenesis was inspected by naked eye and histological observation.

Results

In the experimental group， endochondral bone was seen during the osteoanagenesis process.There was chondroid tissue formed in the bone defect within 2 weeks， and new mature bone complete healing the defects in 12 weeks while PHBV/SGBG composite almost resorbed at the same time.There was spontaneous ossification in the untreated group， but the healing was incomplete with fibrous tissue in the osteotylus.

Conclusions

PHBV/SGBG has good osteo-conductibility and bone regeneration capability.It may be a promising composite for bone tissue engineering.

Key words: Bioactive glass, Poly hydroxybutyrate-hydroxyvalerate, Composite, Bone defect, Osteogenesis, Animal study

Qian TANG, Jian-hong CHEN, Nan-nan HUANG, Zhu-li PENG, Huan-you LIANG. Bone regeneration ability of PHBV/SGBG composite： an in vivo study[J]. Chinese Journal of Stomatological Research(Electronic Edition), 2010, 4(03): 232-238.

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URL: https://zhkqyxyjzz.cma-cmc.com.cn/EN/10.3877/cma.j.issn.1674-1366.2010.03.004

https://zhkqyxyjzz.cma-cmc.com.cn/EN/Y2010/V4/I03/232

Figures/Tables 12

References 19

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