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Chinese Journal of Stomatological Research(Electronic Edition) ›› 2016, Vol. 10 ›› Issue (04): 272-276. doi: 10.3877/cma.j.issn.1674-1366.2016.04.008

Special Issue:

• Clinic Research • Previous Articles     Next Articles

The study of serum neopterin levels in patients with periodontal disease and coronary heart disease

Jing Ren1, Shan Chen1, Jing Dai1, Yanbin Chen1, Qianbing Zhou1, Junying Yang1,()   

  1. 1. Department of Stomatology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou 510080, China
  • Received:2016-06-02 Online:2016-08-01 Published:2016-08-01
  • Contact: Junying Yang
  • About author:
    Corresponding author: Yang Junying, Email:

Abstract:

Objective

To explore the possible relationship of serum neopterin levels with chronic periodontitis and coronary heart disease (CHD) .

Methods

A total of 120 patients were recruited in this study, including 30 patients with periodontitis and coronary heart disease (C+P) , 30 patients with periodontitis (P) , 30 patients with coronary heart disease (C) , 30 healthy controls (H) . All parameters, including age, gender and periodontal clinic index, were recorded. Serum neopterin levels and lipid levels were examined at the same time. Differences in parameters among the four groups were analyzed by ANOVA. Correlations of each serum parameters with periodontal indexes were analyzed by Pearson correlation.

Results

The periodontal indexes were significantly different among the four groups (P<0.05) . In (C+ P) group, serum neopterin levels were significantly higher than that of P, C and H groups (P<0.05) . The serum neopterin levels of P and C groups were significantly higher than that of H group (P<0.05) . Serum neopterin levels were significantly correlated to probing depth and clinical attachment loss.

Conclusions

A certain correlation might exist between periodontitis and CHD, and neopterin might be closely related with the pathogenesis of these two diseases.

Key words: Periodontal disease, Coronary heart disease, Neopterin, Clinical attachment loss, Inflammation

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