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中华口腔医学研究杂志(电子版) ›› 2021, Vol. 15 ›› Issue (06) : 375 -381. doi: 10.3877/cma.j.issn.1674-1366.2021.06.008

综述

硅离子在骨组织修复再生领域的作用
陈伟洋1, 田俊1, 韦曦1,†()   
  1. 1. 中山大学附属口腔医院，光华口腔医学院，广东省口腔医学重点实验室，广州　510055
  • 收稿日期:2021-02-22 出版日期:2021-12-01
  • 通信作者: 韦曦

The role of silicon ion in the field of bone regeneration

Weiyang Chen1, Jun Tian1, Xi Wei1,†()   

  1. 1. Hospital of Stomatology, Guanghua School of Stomatology, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Stomatology, Guangzhou 510055, China
  • Received:2021-02-22 Published:2021-12-01
  • Corresponding author: Xi Wei
  • Supported by:
    National Natural Science Foundation of China(81970925); Financial Fund for High-Caliber Hospital Construction of Guangdong Province(174-2018-XMZC-0001-03-0125/A-01)
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陈伟洋, 田俊, 韦曦. 硅离子在骨组织修复再生领域的作用[J]. 中华口腔医学研究杂志(电子版), 2021, 15(06): 375-381.

Weiyang Chen, Jun Tian, Xi Wei. The role of silicon ion in the field of bone regeneration[J]. Chinese Journal of Stomatological Research(Electronic Edition), 2021, 15(06): 375-381.

硅离子参与调节骨生成、骨钙化的生理过程，在骨代谢中发挥着重要作用，硅离子缺乏将导致畸形骨的发生。含硅生物活性材料通过释放含硅离子产物以发挥促血管生成效应、促成骨效应、抑制破骨细胞分化效应及免疫调节效应，有效地促进骨组织修复与再生。本文就硅离子在骨组织修复再生领域的作用作一综述。

关键词: 硅, 骨再生, 成骨分化, 成骨细胞

Silicon ion participates in the physiological process of bone tissue formation and bone tissue mineralization, and plays an important role in bone metabolism. Deficiency of Silicon will lead to bone deformation. Si-containing bioactive materials can promote angiogenesis as well as osteogenesis, on the other hand, inhibit osteoclast differentiation. These mterials also exert immunomodulatory effects through releasing Si-containing ionic products, which can effectively facilitate bone tissue repair and regeneration. In this paper, the role of silicon ion in the field of bone regeneration is reviewed.

Key words: Silicon, Bone regeneration, Osteogenic differentiation, Osteoblasts
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