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中华口腔医学研究杂志(电子版) ›› 2024, Vol. 18 ›› Issue (01) : 1 -4. doi: 10.3877/cma.j.issn.1674-1366.2024.01.001

青年编委专栏

聚焦高黏附力骨黏合剂,促进口腔硬组织修复
李昊(), 韦秀湘, 钟晓霞   
  1. 广西医科大学口腔医学院/附属口腔医院,广西口腔颌面修复与重建研究重点实验室,南宁 530021
  • 收稿日期:2023-07-19 出版日期:2024-02-01
  • 通信作者: 李昊

A strong bone adhesive promotes the reconstruction of oral hard tissue

Hao Li(), Xiuxiang Wei, Xiaoxia Zhong   

  1. College & Affiliated Hospital of Stomatology, Guangxi Medical University, Guangxi Key Laboratory of Oral and Maxillofacial Rehabilitation and Reconstruction, Nanning 530021, China
  • Received:2023-07-19 Published:2024-02-01
  • Corresponding author: Hao Li
  • Supported by:
    National Natural Science Foundation of China(82060195); Guangxi Medical and Health Appropriate Technology Development and Application Project(S2022118)
引用本文:

李昊, 韦秀湘, 钟晓霞. 聚焦高黏附力骨黏合剂,促进口腔硬组织修复[J]. 中华口腔医学研究杂志(电子版), 2024, 18(01): 1-4.

Hao Li, Xiuxiang Wei, Xiaoxia Zhong. A strong bone adhesive promotes the reconstruction of oral hard tissue[J]. Chinese Journal of Stomatological Research(Electronic Edition), 2024, 18(01): 1-4.

生物可降解骨黏合剂是目前生物材料研究领域的热点之一,在骨折固定和骨缺损治疗中已显示出巨大潜力,但在口腔医学领域应用较少。近期,有学者研发了一种黏附力优异、生物相容性好、可促进骨再生的生物可降解超级骨黏合剂,在口腔骨组织黏附、牙体硬组织粘接和骨再生方面实现了新突破。本文评述其研究成果,并展望口腔骨黏合剂未来的研究方向。

Biodegradable bone adhesives attract increasing attention in biomaterial research. These adhesives have exhibited great potential in fracture fixation and bone defect treatment, but they are not commonly used in Dentistry. Recently, researchers have developed a degradable super bone adhesive with excellent adhesion, biocompatibility and performance in promoting bone regeneration. Their findings made new breakthroughs in bone adhesion, tooth bonding and bone regeneration. This article aimed to review their findings and discuss the related research prospects.

[1]
Bingol HBBender JCMEOpsteen JA,et al. Bone adhesive materials:From bench to bedside[J]. Mater Today Bio202319:100599. DOI:10.1016/j.mtbio.2023.100599.
[2]
Hu SWang SHe Q,et al. A mechanically reinforced super bone glue makes a leap in hard tissue strong adhesion and augmented bone regeneration[J]. Adv Sci(Weinh)202310(11):e2206450. DOI:10.1002/advs.202206450.
[3]
Leggat PASmith DRKedjarune U. Surgical applications of cyanoacrylate adhesives:A review of toxicity[J]. ANZ J Surg200777(4):209-213. DOI:10.1111/j.1445-2197.2007.04020.x.
[4]
Hafeez AAFurmeen SSDurairaj D,et al. Application of N-butyl-2-cyanoacrylate for the treatment of comminuted fractures in the anterior wall of the maxillary sinus:A prospective clinical study[J]. Cureus202315(2):e35487. DOI:10.7759/cureus.35487.
[5]
Melrose J. High performance marine and terrestrial bioadhesives and the biomedical applications they have inspired[J]. Molecules202227(24):8982. DOI:10.3390/molecules27248982.
[6]
Shokri MDalili FKharaziha M,et al. Strong and bioactive bioinspired biomaterials,next generation of bone adhesives[J]. Adv Colloid Interface Sci2022305:102706. DOI:10.1016/j.cis.2022.102706.
[7]
Fan HLWang JHGong JP. Barnacle cement proteins-inspired tough hydrogels with robust,long-lasting,and repeatable underwater adhesion[J]. Adv Funct Mater202131(11):2009334. DOI:10.1002/adfm.202009334.
[8]
Li AJia MMu Y,et al. Humid bonding with a water-soluble adhesive inspired by mussels andsandcastle worms[J]. Macromol Chem Phys2015216(4):450-459. DOI:10.1002/macp.201400513.
[9]
Millar NLBradley TAWalsh NA,et al. Frog glue enhances rotator cuff repair in a laboratory cadaveric model[J]. J Shoulder Elbow Surg200918(4):639-645. DOI:10.1016/j.jse.2008.12.007.
[10]
Tzagiollari AMcCarthy HOLevingstone TJ,et al. Biodegradable and biocompatible adhesives for the effective stabilisation,repair and regeneration of bone[J]. Bioengineering(Basel)20229(6):250. DOI:10.3390/bioengineering9060250.
[11]
Hasani-Sadrabadi MMSarrion PPouraghaei S,et al. An engineered cell-laden adhesive hydrogel promotes craniofacial bone tissue regeneration in rats[J]. Sci Transl Med202012(534):eaay6853. DOI:10.1126/scitranslmed.aay6853.
[12]
Liu YHZhu ZPei XB,et al. ZIF-8-modified multifunctional bone-adhesive hydrogels promoting angiogenesis and osteogenesis for bone regeneration[J]. ACS Appl Mater Interfaces202012(33):36978-36995. DOI:10.1021/acsami.0c12090.
[13]
Xu LJGao SZhou R,et al. Bioactive pore-forming bone adhesives facilitating cell ingrowth for fracture healing[J]. Adv Mater202032(10):e1907491. DOI:10.1002/adma.201907491.
[14]
王星月.新型强粘附性载药水凝胶用于增强骨-植入物固定及抗感染的研究[D].长春:吉林大学,2022.
[15]
Wang BLiu JNiu D,et al. Mussel-inspired bisphosphonated injectable nanocomposite hydrogels with adhesive,self-healing,and osteogenic properties for bone regeneration[J]. ACS Appl Mater Interfaces202113(28):32673-32689. DOI:10.1021/acsami.1c06058.
[16]
Sánchez-Fernández MJHammoudeh HFélix Lanao RP,et al. Bone-adhesive materials:Clinical requirements,mechanisms of action,and future perspective[J]. Adv Mater Interfaces20196(4):1802021. DOI:10.1002/admi.201802021.
[17]
Renner TOtto PKübler AC,et al. Novel adhesive mineral-organic bone cements based on phosphoserine and magnesium phosphates or oxides[J]. J Mater Sci Mater Med202334(4):14. DOI:10.1007/s10856-023-06714-6.
[18]
Moazami SKharaziha MEmadi R,et al. Multifunctional bioinspired bredigite-modified adhesive for bone fracture healing[J]. ACS Appl Mater Interfaces202315(5):6499-6513. DOI:10.1021/acsami.2c20038.
[19]
Guo QChen JWang J,et al. Recent progress in synthesis and application of mussel-inspired adhesives[J]. Nanoscale202012(3):1307-1324. DOI:10.1039/c9nr09780e.
[20]
Kunrath MFDahlin C. The impact of early saliva interaction on dental implants and biomaterials for oral regeneration:An overview[J]. Int J Mol Sci202223(4):2024. DOI:10.3390/ijms23042024.
[21]
Howard KCGonzalez OAGarneau-tsodikova S. Porphyromonas gingivalis:Where do we stand in our battle against this oral pathogen?[J]. RSC Med Chem202112(5):666-704. DOI:10.1039/d0md00424c.
[22]
Xu LYe QXie J,et al. An injectable gellan gum-based hydrogel that inhibits Staphylococcus aureus for infected bone defect repair[J]. J Mater Chem B202210(2):282-292. DOI:10.1039/d1tb02230j.
[23]
Ramasamy SKKusumbe APSchiller M,et al. Blood flow controls bone vascular function and osteogenesis[J]. Nat Commun20167:13601. DOI:10.1038/ncomms13601.
[24]
李苑,苏毅,江飞,等.新型通用型粘接剂对牙本质粘接强度的体外研究[J].南京医科大学学报(自然科学版)202040(5):754-758+762. DOI:10.7655/NYDXBNS20190526.
[25]
Wen BDai YGHan X,et al. Biomineralization-inspired mineralized hydrogel promotes the repair and regeneration of dentin/bone hard tissue[J]. NPJ Regen Med20238(1):11. DOI:10.1038/s41536-023-00286-3.
[26]
Li YZhu JZhang X,et al. Drug-delivery nanoplatform with synergistic regulation of angiogenesis-osteogenesis coupling for promoting vascularized bone regeneration[J]. ACS Appl Mater Interfaces202315(14):17543-17561. DOI:10.1021/acsami.2c23107.
[27]
Pirmoradian MHooshmand TNajafi F,et al. Design,synthesis,and characterization of a novel dual cross-linked gelatin-based bioadhesive for hard and soft tissues adhesion capability[J]. Biomed Mater202217(6). DOI:10.1088/1748-605X/ac9268.
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