Patients with stage Ⅳ periodontitis often suffer from severe damage to the periodontal supporting tissues, accompanied by complications such as periodontal abscesses and increased tooth mobility. Among these, pathologic tooth migration (PTM) is a common motivator for seeking treatment due to its impact on aesthetics and masticatory function. Managing PTM is complex and typically requires collaborative efforts from multiple disciplines involving periodontics, orthodontics, and prosthodontics to develop a comprehensive treatment plan. Restoring periodontal health through systematic periodontal therapy is a critical foundation in the treatment process. Healthy periodontal tissues serve as a key prerequisite for successful orthodontic and prosthetic interventions, ensuring the smooth implementation of multidisciplinary treatment strategies. This article systematically reviews the multidisciplinary treatment of stage Ⅳ periodontitis with pathological tooth displacement, supplemented by a clinical case involving combined periodontal-orthodontic therapy. The findings provide valuable insights for the management of such cases.