Radiation-induced oral tissue injury during boron neutron capture therapy to head and neck cancers

doi:10.3877/cma.j.issn.1674-1366.2025.03.008

Abstract

Abstract:

As a cutting-edge cancer treatment，boron neutron capture therapy（BNCT）has attracted attentions due to its excellent characteristics of cell-level damage. However，due to the tumor-targeting limitation of boron drugs and delivery accuracy of neutron beam，oral normal tissues are injured by radiation during BNCT of head and neck cancers，which affecting the completion of treatment and quality of patients'life. This article reviews the radiation characteristics of BNCT，as well as the damage of radiation to normal oral tissues during BNCT and its mechanisms，such as radiation-induced oral mucositis，vascular injury and salivary gland injury. Radiation protection agents，vascular repair treatments and traditional Chinese medicine treatments can be used as prevention or treatment strategies for normal tissue injury after BNCT. Future research should focus on the mechanism of normal tissue damage in BNCT and develop effective radiation protection agents for injury targets，so as to improve the efficacy and safety of BNCT and improve the prognosis and quality of life of patients.

Key words: Boron neutron capture therapy, Oral normal tissue, Radiation injuries, Radiation protection, Head and neck neoplasms

Zhiyi Wang, Jiahui Wu, Shijiao Shen, Xiyue Lan, Lin Ma. Radiation-induced oral tissue injury during boron neutron capture therapy to head and neck cancers[J]. Chinese Journal of Stomatological Research(Electronic Edition), 2025, 19(03): 204-209.

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