The impact of maternal systemic diseases on the incidence of cleft lip and palate in newborns

doi:10.3877/cma.j.issn.1674-1366.2024.04.008

Abstract

Abstract:

Cleft lip and palate are among the most common congenital anomalies, with aetiology that is complex and currently considered to be the result of both genetic and environmental factors. This condition can lead to issues in facial and dental development, speech, nutrition, and hearing, which not only impact the physiological and socio-psychological well-being of the child but also increase the financial burden on the family. Numerous studies have established a clear association between maternal systemic diseases and the risk of offspring developing cleft lip and palate. This article reviewed the relationship and mechanisms of action between four systemic diseases—diabetes, hypertension, obesity, and systemic lupus erythematosus—as well as periodontitis, which are closely related to systemic diseases, and their association with the occurrence of cleft lip and palate. It aimed to provide a clinical reference for the prevention and reduction of the incidence of cleft lip and palate during pregnancy from the perspective of systemic diseases, thereby avoiding or minimizing the risk of congenital cleft lip and palate in offspring.

Key words: Cleft lip, Cleft palate, Diabetes mellitus, Hypertension, Obesity, Lupus erythematosus, systemic, Periodontitis

Ka Teng Chan, Meijun Du, Bing Shi, Hanyao Huang. The impact of maternal systemic diseases on the incidence of cleft lip and palate in newborns[J]. Chinese Journal of Stomatological Research(Electronic Edition), 2024, 18(04): 262-268.

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