Research progress of plant-derived natural products against oral bacterial infectious disease

doi:10.3877/cma.j.issn.1674-1366.2023.03.006

Abstract

Abstract:

Natural products are compounds derived from nature that are pharmacologically bioactive. Among them, plant-derived natural products have attracted attention for their wide antibacterial effect, low cytotoxicity, and good biocompatibility. Plant-derived natural products mainly include polyphenols, alkaloids, terpenoids, quinones and aldehydes, which can be antibacterial by damaging bacterial membrane structure, inhibiting bacterial enzyme activity, inducing oxidative stress response, promoting iron ion chelation, and inhibiting bacterial binary signaling pathway. In recent years, studies have found that plant-derived natural products can inhibit common oral pathogenic bacteria such as Streptococcus mutans, Porphyromonas-gingivalis, and Enterococcus faecalis. This article reviewed the antibacterial mechanism of plant-derived natural products and their related applications in the treatment of oral infectious diseases.

Key words: Plant-derived compounds, Natural products, Anti-bacterial agent

Yixue Li, Ting Pan, Huancai Lin, Yan Zhou. Research progress of plant-derived natural products against oral bacterial infectious disease[J]. Chinese Journal of Stomatological Research(Electronic Edition), 2023, 17(03): 188-196.

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References 75

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天然产物分类及化合物				抗菌种类	最低抑菌浓度	参考文献
多酚	类黄酮	黄酮醇	槲皮素	变形链球菌	2 mg/mL	[18,20]
				牙龈卟啉单胞菌	4 mg/mL
				粪肠球菌	512 mg/mL
			杨梅素	变形链球菌	512 μg/mL	[22,25]
				粪肠球菌	250 μg/mL
		黄酮	黄芩素	变形链球菌	-	[27]
				白色念珠菌
			芹菜素	白色念珠菌	5 μg/mL	[29]
		黄烷酮	松属素	变形链球菌	（1.4 ± 0.4）μg/mL	[30,31]
				粪肠球菌
		黄烷醇	EGCG	变形链球菌	31.25 μg/mL	[5,13,33]
				粪肠球菌	5 μg/mL
				牙龈卟啉单胞菌	-
		异黄酮	光甘草定	变形链球菌	6.25 ~ 25 μg/mL	[34,35,36]
				粪肠球菌	25 μg/mL
	非类黄酮	单宁类	没食子单宁	变形链球菌	-	[37]
				牙龈卟啉单胞菌	-
			缩合单宁	粪肠球菌	-	[39,41]
		姜黄素		变形链球菌	-	[10,42,43,44,45]
				牙龈卟啉单胞菌	62.5 ~ 125 μg/mL
				粪肠球菌	-
		厚朴酚		变形链球菌	10 μg/mL	[46]
		白藜芦醇		变形链球菌	800 μg/mL	[49,50]
				牙龈卟啉单胞菌	-
		咖啡酸苯乙酯		变形链球菌	0.08 μg/mL	[52]
				白色念珠菌	-
萜类	单萜类	香芹酚		变形链球菌	93.4 μg/mL	[53]
		百里酚		变形链球菌	-	[54]
				白色念珠菌	39 μg/mL
		萜品烯四醇		变形链球菌	-	[55]
				白色念珠菌	2.34 mg/mL
	倍半萜	反式法尼醇		变形链球菌	6.25 mmol/L	[3,57]
				白色念珠菌	150 mmol/L
	二萜	松萝酸		变形链球菌	5 μg/mL	[58]
	三萜	熊果酸		变形链球菌	256 ~ 1 024 μg/mL	[59]
		人参皂苷Rh2		变形链球菌	-	[61]
				远缘链球菌
				血链球菌
	四萜	辣椒素		变形链球菌	50 μg/mL	[63,64]
				粪肠球菌	256 μg/mL
				牙龈卟啉单胞菌	16 μg/mL
生物碱类		血根碱		变形链球菌	4 ~ 8 μg/mL	[65]
		小檗碱		变形链球菌	300 μg/mL	[67,68,69,70]
				粪肠球菌	500 μg/mL
				白色念珠菌	31.25 μg/mL
				牙龈卟啉单胞菌	31.3 μg/mL
醌类		大黄酸		变形链球菌	5.69 μg/mL	[72,73]
				牙龈卟啉单胞菌	15.625 μg/mL
醛类		肉桂醛		变形链球菌	1 000 ~ 2 000 μg/mL	[14,74,75]
				粪肠球菌	250 ~ 500 μg/mL

天然产物分类及化合物				抗菌种类	最低抑菌浓度	参考文献
多酚	类黄酮	黄酮醇	槲皮素	变形链球菌	2 mg/mL	[18,20]
				牙龈卟啉单胞菌	4 mg/mL
				粪肠球菌	512 mg/mL
			杨梅素	变形链球菌	512 μg/mL	[22,25]
				粪肠球菌	250 μg/mL
		黄酮	黄芩素	变形链球菌	-	[27]
				白色念珠菌
			芹菜素	白色念珠菌	5 μg/mL	[29]
		黄烷酮	松属素	变形链球菌	（1.4 ± 0.4）μg/mL	[30,31]
				粪肠球菌
		黄烷醇	EGCG	变形链球菌	31.25 μg/mL	[5,13,33]
				粪肠球菌	5 μg/mL
				牙龈卟啉单胞菌	-
		异黄酮	光甘草定	变形链球菌	6.25 ~ 25 μg/mL	[34,35,36]
				粪肠球菌	25 μg/mL
	非类黄酮	单宁类	没食子单宁	变形链球菌	-	[37]
				牙龈卟啉单胞菌	-
			缩合单宁	粪肠球菌	-	[39,41]
		姜黄素		变形链球菌	-	[10,42,43,44,45]
				牙龈卟啉单胞菌	62.5 ~ 125 μg/mL
				粪肠球菌	-
		厚朴酚		变形链球菌	10 μg/mL	[46]
		白藜芦醇		变形链球菌	800 μg/mL	[49,50]
				牙龈卟啉单胞菌	-
		咖啡酸苯乙酯		变形链球菌	0.08 μg/mL	[52]
				白色念珠菌	-
萜类	单萜类	香芹酚		变形链球菌	93.4 μg/mL	[53]
		百里酚		变形链球菌	-	[54]
				白色念珠菌	39 μg/mL
		萜品烯四醇		变形链球菌	-	[55]
				白色念珠菌	2.34 mg/mL
	倍半萜	反式法尼醇		变形链球菌	6.25 mmol/L	[3,57]
				白色念珠菌	150 mmol/L
	二萜	松萝酸		变形链球菌	5 μg/mL	[58]
	三萜	熊果酸		变形链球菌	256 ~ 1 024 μg/mL	[59]
		人参皂苷Rh2		变形链球菌	-	[61]
				远缘链球菌
				血链球菌
	四萜	辣椒素		变形链球菌	50 μg/mL	[63,64]
				粪肠球菌	256 μg/mL
				牙龈卟啉单胞菌	16 μg/mL
生物碱类		血根碱		变形链球菌	4 ~ 8 μg/mL	[65]
		小檗碱		变形链球菌	300 μg/mL	[67,68,69,70]
				粪肠球菌	500 μg/mL
				白色念珠菌	31.25 μg/mL
				牙龈卟啉单胞菌	31.3 μg/mL
醌类		大黄酸		变形链球菌	5.69 μg/mL	[72,73]
				牙龈卟啉单胞菌	15.625 μg/mL
醛类		肉桂醛		变形链球菌	1 000 ~ 2 000 μg/mL	[14,74,75]
				粪肠球菌	250 ~ 500 μg/mL

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