Research progress of m6A RNA methylation modification involved in the regulation of stem cell multidirectional differentiation

doi:10.3877/cma.j.issn.1674-1366.2020.04.001

Abstract

Abstract:

m⁶A modification is one of the most pervasive methylation modifications in RNA, which belongs to the epigenetic regulation at the post-transcriptional level. m⁶A RNA methylation modification includes the process of writing, erasing and reading, which affects a variety of biological functions by participating in the multidirectional differentiation of stem cells. In recent years, it has been found that whether in physiological or pathological state, m⁶A modification can change the replication ability and differentiation direction of stem cells by regulating the self-renewal and differentiation of stem cells, and subsequently affect the process of tissue maturation and disease progression. This article described the modification mechanism of m⁶A in RNA, and focused on the role of m⁶A modification in the regulation of self-renewal and multidirectional differentiation of several kinds of stem cells.

Key words: m⁶A modification, Stem cells, RNA methylation

Xu Zhang, Wen Qin, Jia Liu, Zuolin Jin. Research progress of m⁶A RNA methylation modification involved in the regulation of stem cell multidirectional differentiation[J]. Chinese Journal of Stomatological Research(Electronic Edition), 2020, 14(04): 201-206.

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References 45

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