Osteosarcoma of the jaws: study and literature review with 3 cases

doi:10.3877/cma.j.issn.1674-1366.2019.02.008

Abstract

Abstract:

Objective

To investigate the clinicopathological features of the osteosarcoma in the jaws bones and its diagnosis, differential diagnosis and literature review.

Methods

A retrospective study was made on 3 cases of osteosarcoma of the jaws in our hospital, combined with the imaging materials, to study the microscopical histology and review the literature.

Results

In case 1 the tumor located in the left maxilla and in case 2 the tumor located in the left mandible. Both two cases were diagnosed as conventional osteosarcoma. In case 3 the lesion located in the right mandible and it was diagnosed as low-grade central osteosarcoma. The osteosarcoma of the jaws bones is rare in clinic, and it has its own characteristic compared with osteosarcoma of long bone.

Conclusions

The osteosarcoma of the jaws have its characteristic in age of onset andmicroscopical histology. It is necessary to be differentiated from benign bone diseases with data of clinical features, radiology and pathological microscopic morphology.

Key words: Jaws, Osteosarcoma, Malignant tumour, Diagnosis

Lishan Tan, Zhihui Chen, Yuying Chen, Liqi Wu, Hui Guo. Osteosarcoma of the jaws: study and literature review with 3 cases[J]. Chinese Journal of Stomatological Research(Electronic Edition), 2019, 13(02): 108-113.

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References 22

[1]	Klein MJ, Siegal GP. Osteosarcoma：anatomic and histologic variants[J]. Am J Clin Pathol，2006，125(4):555-581. DOI：10.1309/UC6KQHLD9LV2KENN.
[2]	Mayur Chaudhary, Shweta Dixit Chaudhary. Osteosarcoma of jaws[J]. J Oral Maxillofac Pathol，2012，16(2):233-238.
[3]	Paparella ML, Olvi LG, Brandizzi D，et al. Osteosarcoma of the jaw：an analysis of a series of 74 cases[J]. Histopathology，2013，63(4):551-557. DOI：10.1111/his.12191.
[4]	Yildiz FR, Avci A, Dereci O，et al. Gnathic osteosarcomas，experience of four institutions from Turkey[J]. Int J Clin Exp Pathol，2014，7(6):2800-2808. DOI：10.1186/bcr3632.
[5]	Junior AT, de Abreu Alves F, Pinto CA，et al. Clinicopathological and immunohistochemical analysis of twenty-five head and neck osteosarcomas[J]. Oral Oncol，2003，39(5):521-530. DOI：10.1016/S1368-8375(03)00017-4.
[6]	McGuff HS, Heim-Hall J, Holsinger FC，et al. Maxillary osteosarcoma associated with a dental implant：report of a case and review of the literature regarding implant-related sarcomas[J]. Am Dent Assoc，2008，139(8):1052-1059. DOI：10.14219/jada.archive.2008.0307.
[7]	Adel KE, John KC, Jennifer RG，et al. Osteosarcoma. In：WHO Classification of Head and Neck Tumours[M]. Lyon：IARC Press，2017：244-246.
[8]	刘彤华.诊断病理学[M].北京：人民卫生出版社，2013：913-918.
[9]	Muramatsu K, Hashimoto T, Seto S，et al. Low-grade central osteosarcoma mimicking fibrous dysplasia：a report of two cases[J]. Arch Orthop Trauma Surg，2008，128(1):11-15. DOI：10.1007/s00402-006-0280-9.
[10]	Oliveira P, Nogueira M, Pinto A，et al. Analysis of p53 expression in osteosarcoma of the jaw：correlation with clinicopathologic and DNA ploidy findings[J]. Human Pathol，1997，28(12):1361-1365. DOI：10.1016/S0046-8177(97)90224-0.
[11]	Lopes MA, Nikitakis NG, Ord RA，et al. Amplification and protein expression of chromosome 12q13-15 genes in osteosarcomas of the jaws[J]. Oral Oncol，2001，37(7):566-571. DOI：10.1016/S1368-8375(00)00130-5.
[12]	Park HR, Park YK. Expression of p53 protein，PCNA，and Ki-67 in osteosarcomas of bone[J]. Korean Med Sci，1995，10(5):360-367. DOI：10.3346/jkms.1995.10.5.360.
[13]	Yoshida A, Ushiku T, Motoi T，et al. Immunohistochemical analysis of MDM2 and CDK4 distinguishes low-grade osteosarcoma from benign mimics[J]. Mod Pathol，2010，23(9):1279-1288. DOI：10.1038/modpathol.2010.124.
[14]	Hayashi K, Tsuchiya H, Yamamoto N，et al. Diagnosis and treatment of low-grade osteosarcoma：experience with nine cases[J]. Int J Clin Oncol，2014，19(4):731-738. DOI：10.1007/s10147-013-0592-z.
[15]	徐方平，骆新兰，梅平，等.颌骨骨肉瘤3例临床病理观察[J].诊断病理学杂志，2017，24(5):346-349.DOI：10.3969/j.issn.1007-8096.2017.05.008.
[16]	ALQahtani D, AlSheddi M, Al-Sadhan R. Epithelioid Osteosarcoma of the Maxilla：A Case Report and Review of the Literature[J]. Int J Surg Pathol，2015，23(6):495-499. DOI：10.1177/1066896915591273.
[17]	Lee RJ, Arshi A, Schwartz HC，et al. Characteristics and prognostic factors of osteosarcoma of the jaws：a retrospective cohort study[J]. JAMA Otolaryngol Head Neck Surg，2015，141(5):470-477. DOI：10.1001/jamaoto.2015.0340.
[18]	Tabatabaei SH, Jahanshahi G, Dehghan Marvasti F. Diagnostic challenges of low-grade central osteosarcoma of jaw：a literature review[J]. Dent（Shiraz），2015，16(2):62-67.
[19]	Argon A, Doğanavşargıl B, ÜnalYıldırım F，et al. Osteosarcomas of jaw：experience of a single centre[J]. J Plast Surg Hand Surg，2015，49(1):13-18.
[20]	Demicco EG, Deshpande V, Nielsen GP，et al. Well-differentiated osteosarcoma of the jaw bones：a clinicopathologic study of 15 cases[J]. Am J Surg Pathol，2010，34(11):1647-1655. DOI：10.1097/PAS.0b013e3181f7dac6.
[21]	Angiero F, Moltrasio F, Cattoretti G，et al. Clinical and histopathological profile of primary or secondary osteosarcoma of the jaws[J]. Anticancer Res，2011，31(12):4485-4489.
[22]	Mardinger O, Givol N, Talmi YP，et al. Osteosarcoma of the jaw. The Chasm Sheba Medical Center experience[J]. Oral Surg Oral Med Oral Pathol Oral Radiol Endod，2001，91(4):445-451. DOI：10.1067/moe.2001.112330.

诊断	MDM2	CDK4	Vimentin	P53	CK	S100	Ki-67
病例1（左上颌骨）普通型骨肉瘤，高级别	+	+	+	+	-	-	40%+
病例2（左下颌骨）普通型骨肉瘤，高级别	+	+	+	+	-	-	50%+
病例3（右下颌角）低级别中心性骨肉瘤	-	+	+	+	-	-	30%+
良性骨病（纤维结构不良）	-	-	+	-	-	-	较低

诊断	MDM2	CDK4	Vimentin	P53	CK	S100	Ki-67
病例1（左上颌骨）普通型骨肉瘤，高级别	+	+	+	+	-	-	40%+
病例2（左下颌骨）普通型骨肉瘤，高级别	+	+	+	+	-	-	50%+
病例3（右下颌角）低级别中心性骨肉瘤	-	+	+	+	-	-	30%+
良性骨病（纤维结构不良）	-	-	+	-	-	-	较低

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