The expression and significance of ATG5 and ATG7 in erosive oral lichen planus

doi:10.3877/cma.j.issn.1674-1366.2011.06.005

Abstract

Abstract:

Objective

To investigate the expressions of ATG5 and ATG7 in erosive oral lichen planus， and explore the role of autophagy in the malignant transformation of oral lichen planus.

Methods

The expressions of ATG5 and ATG7 were detected by immunochemistry in the normal oral mucosa， erosive oral lichen planus and oral squamous cell carcinomas.

Results

The expressions of ATG5 and ATG7 were positive in the above three different tissues.The expression levels of ATG5 and ATG7 were much higher in erosive oral lichen planus than in normal oral mucosa as were as oral squamous cell carcinomas（P ＜0.05）.

Conclusion

The abnormal autophagy exists in erosive oral lichen planus.

Key words: ATG5, ATG7, Oral lichen planus, Autophagy

Zhen CHANG, Chun-yang LI, Rong-lin LI, Jia-li MO. The expression and significance of ATG5 and ATG7 in erosive oral lichen planus[J]. Chinese Journal of Stomatological Research(Electronic Edition), 2011, 5(06): 584-588.

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URL: https://zhkqyxyjzz.cma-cmc.com.cn/EN/10.3877/cma.j.issn.1674-1366.2011.06.005

https://zhkqyxyjzz.cma-cmc.com.cn/EN/Y2011/V5/I06/584

Figures/Tables 4

References 10

1	Rhodus NL， Cheng B， Ondrey F.Th1/Th2 cytokine ratio in tissue transudates from patients with oral lichen planus.Mediators Inflamm，2007，2007:19854.
2	World Health Organization.Tobacco or health: a global status report.Geneve， Switzerland: World Health Organization， 1997.
3	Ismail SB， Kumar SK， Zain RB.Oral lichen planus and lichenoid reactions: etiopathogenesis， diagnosis， management and malignant transformation.J Oral Sci， 2007，49（2）:89-106.
4	Nakatogawa H， Suzuki K， Kamada Y， et al.Dynamics and diversity in autophagy mechanisms: lessons from yeast.Nat Rev Mol Cell Biol，2009，10（7）:458-467.
5	Levine B， Kroemer G.Autophagy in the pathogenesis of disease.Cell， 2008，132（1）:27-42.
6	Mathew R， Karantza-Wadsworth V， White E.Role of autophagy in cancer.Nat Rev Cancer， 2007，7（12）:961-967.
7	Mathew R， Karp CM， Beaudoin B.et al.Autophagy suppresses tumorigenesis through elimination of p62.Cell， 2009，137（6）:1062-1075.
8	Guo JY， Chen HY， Mathew R， et al.Activated Ras requires autophagy to maintain oxidative metabolism and tumorigenesis.Genes Dev，2011，25（5）:460-470.
9	Yang S， Wang X， Contino G， et al.Pancreatic cancers require autophagy for tumor growth.Genes Dev， 2011，25（7）:717-729
10	Pua HH， Dzhagalov I， Chuck M， et al.A critical role for the autophagy gene Atg5 in T cell survival and proliferation.J Exp Med，2007，204（1）:25-31.

组织	ATG5	ATG7
正常口腔黏膜	+	+
糜烂型OLP	++	++
OSCC	+	++

组织	ATG5	ATG7
正常口腔黏膜	+	+
糜烂型OLP	++	++
OSCC	+	++

组织	ATG5		ATG7
组织	A	P	A	P
正常口腔黏膜	0.091 ± 0.001	0.016	0.066 ± 0.002	0.002
糜烂型OLP	0.100 ± 0.003		0.215 ± 0.010
OSCC	0.081 ± 0.003		0.099 ± 0.007

组织	ATG5		ATG7
组织	A	P	A	P
正常口腔黏膜	0.091 ± 0.001	0.016	0.066 ± 0.002	0.002
糜烂型OLP	0.100 ± 0.003		0.215 ± 0.010
OSCC	0.081 ± 0.003		0.099 ± 0.007

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