The effect of molar-loss on the density of cholinergic fibers in limbic lobe of aged rats

doi:10.3877/cma.j.issn.1674-1366.2008-01-009

Abstract

Abstract:

Objective

To explore the effect of molarless on the density of cholinergic fiber in the limbic lobe of aged rats.

Methods

Forty rats were divided into molar-extraction aged group and control aged group （18 months）， molar-extraction young group and control young group （3 months）. For molar-extraction groups， the left molars were extracted. 2 months after teeth extraction， AChE-positive fibers within hippocampal area CA1， dentate gyrus， anterior and posterior cingulate gyrus of all experimental animals were quantitatively analyzed.

Results

The density of AChE-positive fibers in radiatum layer of CA1 and molecular layer of dentate gyrus in molars extraction aged groups were significantly lower than those in control aged groups（P＜0.05）. The density of AChE-positive fibers in inner granular layer of posterior cingulate gyrus in molars extraction aged groups were significantly lower than those in control aged group （P＜0.01）.

Conclusion

Unilateral loss of molar can accelerate degeneration of cholinergic system in limbic lobe of aged rats. This may be one of the mechanisms of aged learning and memory deficit caused by edentia.

Key words: Molar loss, Learning, Memory, Limbic lobe, Aging

Hong-wen HE, Fang HUANG, Ji-hong ZHU, Yu LIU, Jia-mao CHENG. The effect of molar-loss on the density of cholinergic fibers in limbic lobe of aged rats[J]. Chinese Journal of Stomatological Research(Electronic Edition), 2008, 02(01): 41-45.

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URL: https://zhkqyxyjzz.cma-cmc.com.cn/EN/10.3877/cma.j.issn.1674-1366.2008-01-009

https://zhkqyxyjzz.cma-cmc.com.cn/EN/Y2008/V02/I01/41

Figures/Tables 8

References 10

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组别	海马CA1区		齿状回
组别	左侧	右侧	左侧	右侧
青年对照组	212±15	213±16	254±24	254±24
青年拔牙组	223±14	218±14	248±19	247±18
老年对照组	185±25^*	184±25^*	222±27^*	222±27^*
老年拔牙组	141±26^#	144±24^#	193±24^#	189±23^#

组别	海马CA1区		齿状回
组别	左侧	右侧	左侧	右侧
青年对照组	212±15	213±16	254±24	254±24
青年拔牙组	223±14	218±14	248±19	247±18
老年对照组	185±25^*	184±25^*	222±27^*	222±27^*
老年拔牙组	141±26^#	144±24^#	193±24^#	189±23^#

组别	扣带回前区第Ⅴ层		扣带回后区第Ⅳ层
组别	左侧	右侧	左侧	右侧
青年对照组	181±16	180±18	264±25	266±26
青年拔牙组	180±15	183±16	259±21	257±21
老年对照组	144±26^*	140±26^*	202±26^*	204±24^*
老年拔牙组	134±22^*	133±22^*	162±16^*^#	163±19^*^#

组别	扣带回前区第Ⅴ层		扣带回后区第Ⅳ层
组别	左侧	右侧	左侧	右侧
青年对照组	181±16	180±18	264±25	266±26
青年拔牙组	180±15	183±16	259±21	257±21
老年对照组	144±26^*	140±26^*	202±26^*	204±24^*
老年拔牙组	134±22^*	133±22^*	162±16^*^#	163±19^*^#

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