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Chinese Journal of Stomatological Research(Electronic Edition) ›› 2024, Vol. 18 ›› Issue (01): 54-60. doi: 10.3877/cma.j.issn.1674-1366.2024.01.009

• Review • Previous Articles    

Research advances on the role of mechanosensitive ion channels in odontogenic cells

Zhiqing Xu, Yu Du()   

  1. Hospital of Stomatology, Guanghua School of Stomatology, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Stomatology, Guangdong Provincial Clinical Research Center of Oral Diseases, Guangzhou 510055, China
  • Received:2023-07-20 Online:2024-02-01 Published:2024-01-31
  • Contact: Yu Du
  • Supported by:
    Natural Science Foundation of Guangdong Province(2021A1515010845); Medical Scientific Research Foundation of Guangdong Province(A2022126)

Abstract:

As crucial proteins in sensing mechanical stress, mechanosensitive (MS) ion channels could transform external mechanical stimuli into electrochemical signals, enabling ion transmembrane movement. This movement signals the intracellular regulation of target genes. While various MS ion channels are present in odontogenic cell membranes, their roles in the cellular regulation and the exact mechanisms are still not fully understood. This review focused on the classification, expression, and functionality of MS ion channels in odontogenic cells.

Key words: Mechanosensitive channels, Tooth regeneration, PIEZO, TRP channels

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