Research progress in orthodontic pain

doi:10.3877/cma.j.issn.1674-1366.2023.02.014

Abstract

Abstract:

Pain is one of the most common adverse reactions during orthodontic treatment. Reducing orthodontic pain not only improves the patients′ oral health-related quality of life and provides them comfortable treatment experience, but also improves the patient compliance and treatment effect, leading to positive clinical significance. However, there are no widely used orthodontic pain relief measures in clinical practice now. Four aspects of orthodontic pain were discussed in this article, including molecular mechanisms, influencing factors, assessment methods, and relief measures, in the hope of providing a reference for clinical practice.

Key words: Orthodontics, Pain, Trigeminal nerve

Xiqin Li, Youjian Peng. Research progress in orthodontic pain[J]. Chinese Journal of Stomatological Research(Electronic Edition), 2023, 17(02): 148-152.

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References 59

[1]	Montebugnoli F，Incerti Parenti S，D′Antò V，et al. Effect of verbal and written information on pain perception in patients undergoing fixed orthodontic treatment：A randomized controlled trial[J]. Eur J Orthod，2020，42（5）：494-499. DOI：10.1093/ejo/cjz068.
[2]	Cheng C，Xie T，Wang J. The efficacy of analgesics in controlling orthodontic pain：A systematic review and meta-analysis[J]. BMC Oral Health，2020，20（1）：259. DOI：10.1186/s12903-020-01245-w.
[3]	陈扬熙.口腔正畸学——基础、技术与临床[M].北京：人民卫生出版社，2012：732-734.
[4]	Gao M，Long H，Ma W，et al. The role of periodontal ASIC3 in orofacial pain induced by experimental tooth movement in rats[J]. Eur J Orthod，2016，38（6）：577-583. DOI：10.1093/ejo/cjv082.
[5]	Yang H，Shan D，Jin Y，et al. The role of acid-sensing ion channel 3 in the modulation of tooth mechanical hyperalgesia induced by orthodontic tooth movement[J]. Neuroscience，2020，442：274-285. DOI：10.1016/j.neuroscience.2020.06.023.
[6]	Qiao H，Gao Y，Zhang C，et al. Increased expression of TRPV1 in the trigeminal ganglion is involved in orofacial pain during experimental tooth movement in rats[J]. Eur J Oral Sci，2015，123（1）：17-23. DOI：10.1111/eos.12158.
[7]	Wang S，Kim M，Ali Z，et al. Corrigendum：TRPV1 and TRPV1-expressing nociceptors mediate orofacial pain behaviors in a mouse model of orthodontic tooth movement[J]. Front Physiol，2019，10：1353. DOI：10.3389/fphys.2019.01353.
[8]	Thammanichanon P，Kaewpitak A，Binlateh T，et al. Interval vibration reduces orthodontic pain via a mechanism involving down-regulation of TRPV1 and CGRP[J]. In Vivo，2020，34（5）：2389-2399. DOI：10.21873/invivo.12052.
[9]	Long H，Wang Y，Jian F，et al. Current advances in orthodontic pain[J]. Int J Oral Sci，2016，8（2）：67-75. DOI：10.1038/ijos.2016.24.
[10]	Kyrkanides S，Huang H，Faber RD. Neurologic regulation and orthodontic tooth movement[J]. Front Oral Biol，2016，18：64-74. DOI：10.1159/000351900.
[11]	Liang H，Hu H，Shan D，et al. CGRP modulates orofacial pain through mediating neuron-glia crosstalk[J]. J Dent Res，2021，100（1）：98-105. DOI：10.1177/0022034520950296.
[12]	Tang Z，Zhou J，Long H，et al. Molecular mechanism in trigeminal nerve and treatment methods related to orthodontic pain[J]. J Oral Rehabil，2022，49（2）：125-137. DOI：10.1111/joor.13263.
[13]	Cuoghi OA，Topolski F，de Faria LP，et al. Pain and tissue damage in response to orthodontic tooth movement：Are they correlated？[J]. J Contemp Dent Pract，2016，17（9）：713-720. DOI：10.5005/jp-journals-10024-1918.
[14]	万丽，赵晴，陈军，等.疼痛评估量表应用的中国专家共识（2020版）[J].中华疼痛学杂志，2020，16（3）：177-187. DOI：10.3760/cma.j.cn101379-20190915-00075
[15]	Gupta SP，Rauniyar S，Prasad P，et al. A randomized controlled trial to evaluate the effectiveness of different methods on pain management during orthodontic debonding[J]. Prog Orthod，2022，23（1）：7. DOI：10.1186/s40510-022-00401-y.
[16]	Melzack R. The short-form McGill Pain Questionnaire[J]. Pain，1987，30（2）：191-197. DOI：10.1016/0304-3959(87)91074-8.
[17]	Iwasaki LR，Freytag LE，Schumacher CA，et al. Validation of a modified McGill Pain Questionnaire for orthodontic patients[J]. Angle Orthod，2013，83（5）：906-912. DOI：10.2319/110812-859.1.
[18]	Sandhu SS. Validating the factor structure and testing measurement invariance of modified Short-Form McGill Pain Questionnaire（Ortho-SF-MPQ）for orthodontic pain assessment[J]. J Orthod，2017，44（1）：34-43. DOI：10.1080/14653125.2016.1275442.
[19]	Navabi N，Farnudi H，Rafiei H，et al. Orthodontic treatment and the oral health-related quality of life of patients[J]. J Dent（Tehran），2012，9（3）：247-254.
[20]	Huang R，Wang J，Wu D，et al. The effects of customised brainwave music on orofacial pain induced by orthodontic tooth movement[J]. Oral Dis，2016，22（8）：766-774. DOI：10.1111/odi.12542.
[21]	An JX，Wang Y，Cope DK，et al. Quantitative evaluation of pain with pain index extracted from electroencephalogram[J]. Chin Med J（Engl），2017，130（16）：1926-1931. DOI：10.4103/0366-6999.211878.
[22]	高金辉.初戴隐形矫治器、Damon Q自锁托槽与直丝弓托槽对成人正畸疼痛及龈沟液内炎性因子的影响[J].当代医学，2022，28（5）：54-56. DOI：10.3969/j.issn.1009-4393.2022.05.019.
[23]	Borsook D，Becerra LR. Breaking down the barriers：fMRI applications in pain，analgesia and analgesics[J]. Mol Pain，2006，2：30. DOI：10.1186/1744-8069-2-30.
[24]	Yang H，Yang X，Liu H，et al. Placebo modulation in orthodontic pain：A single-blind functional magnetic resonance study[J]. Radiol Med，2021，126（10）：1356-1365. DOI：10.1007/s11547-021-01374-4.
[25]	安然，杨馨惟，雷浪.固定矫治器与隐形矫治器对正畸治疗疼痛影响差异的Meta分析[J].中国实用口腔科杂志，2021，14（5）：586-590. DOI：10.19538/j.kq.2021.05.015.
[26]	Almasoud NN. Pain perception among patients treated with passive self-ligating fixed appliances and Invisalign^® aligners during the first week of orthodontic treatment[J]. Korean J Orthod，2018，48（5）：326-332. DOI：10.4041/kjod.2018.48.5.326.
[27]	Gao M，Yan X，Zhao R，et al. Comparison of pain perception，anxiety，and impacts on oral health-related quality of life between patients receiving clear aligners and fixed appliances during the initial stage of orthodontic treatment[J]. Eur J Orthod，2021，43（3）：353-359. DOI：10.1093/ejo/cjaa037.
[28]	Lin YL，Lin Y，Fang F，et al. The use of sel-ligating appliance can reduce inflammatory response to orthodontic force and keep periodontal health in orthodontic treatment[J]. Am J Transl Res，2021，13（10）：11680-11688.
[29]	Lai TT，Chiou JY，Lai TC，et al. Perceived pain for orthodontic patients with conventional brackets or self-ligating brackets over 1 month period：A single-center，randomized controlled clinical trial[J]. J Formos Med Assoc，2020，119（1 Pt 2）：282-289. DOI：10.1016/j.jfma.2019.05.014.
[30]	Casteluci CEVF，Oltramari PVP，Conti PCR，et al. Evaluation of pain intensity in patients treated with aligners and conventional fixed appliances：Randomized clinical trial[J]. Orthod Craniofac Res，2021，24（2）：268-276. DOI：10.1111/ocr.12431.
[31]	Cardoso PC，Espinosa DG，Mecenas P，et al. Pain level between clear aligners and fixed appliances：A systematic review[J]. Prog Orthod，2020，21（1）：3. DOI：10.1186/s40510-019-0303-z.
[32]	Ileri Z，Baka ZM，Akin M，et al. Effect of menstrual cycle on orthodontic pain perception：A controlled clinical trial[J]. J Orofac Orthop，2016，77（3）：168-175. DOI：10.1007/s00056-016-0013-9.
[33]	Nahin RL. Estimates of pain prevalence and severity in adults：United States，2012[J]. J Pain，2015，16（8）：769-80. DOI：10.1016/j.jpain.2015.05.002.
[34]	王锦琰.遗传、疼痛与镇痛[J].中国疼痛医学杂志，2006，12（1）：2-3. DOI：10.3969/j.issn.1006-9852.2006.01.001.
[35]	Lin W，Farella M，Antoun JS，et al. Factors associated with orthodontic pain[J]. J Oral Rehabil，2021，48（10）：1135-1143. DOI：10.1111/joor.13227.
[36]	Cioffi I，Michelotti A，Perrotta S，et al. Effect of somatosensory amplification and trait anxiety on experimentally induced orthodontic pain[J]. Eur J Oral Sci，2016，124（2）：127-134. DOI：10.1111/eos.12258.
[37]	Al-Melh MA，Andersson L. The effect of a lidocaine/prilocaine topical anesthetic on pain and discomfort associated with orthodontic elastomeric separator placement[J]. Prog Orthod，2017，18（1）：1. DOI：10.1186/s40510-016-0156-7.
[38]	Topolski F，Moro A，Correr GM，et al. Optimal management of orthodontic pain[J]. J Pain Res，2018，11：589-598. DOI：10.2147/JPR.S127945.
[39]	Eslamipour F，Motamedian SR，Bagheri F. Ibuprofen and low-level laser therapy for pain control during fixed orthodontic therapy：A systematic review of randomized controlled trials and meta-analysis[J]. J Contemp Dent Pract，2017，18（6）：527-533. DOI：10.5005/jp-journals-10024-2078.
[40]	Corrêa AS，Almeida VL，Lopes BMV，et al. The influence of non-steroidal anti-inflammatory drugs and paracetamol used for pain control of orthodontic tooth movement：A systematic review[J]. An Acad Bras Cienc，2017，89（4）：2851-2863. DOI：10.1590/0001-3765201720160865.
[41]	Ren C，McGrath C，Gu M，et al. Low-level laser-aided orthodontic treatment of periodontally compromised patients：A randomised controlled trial[J]. Lasers Med Sci，2020，35（3）：729-739. DOI：10.1007/s10103-019-02923-0.
[42]	AlSayed Hasan MMA，Sultan K，Hamadah O. Evaluating low-level laser therapy effect on reducing orthodontic pain using two laser energy values：A split-mouth randomized placebo-controlled trial[J]. Eur J Orthod，2018，40（1）：23-28. DOI：10.1093/ejo/cjx013.
[43]	Qamruddin I，Alam MK，Mahroof V，et al. Photobiostimulatory effect of a single dose of low-level laser on orthodontic tooth movement and pain[J]. Pain Res Manag，2021：6690542. DOI：10.1155/2021/6690542.
[44]	Mirhashemi A，Rasouli S，Shahi S，et al. Efficacy of photobiomodulation therapy for orthodontic pain control following the placement of elastomeric separators：A randomized clinical trial[J]. J Lasers Med Sci，2021，12：e8. DOI：10.34172/jlms.2021.08.
[45]	Fleming PS，Strydom H，Katsaros C，et al. Non-pharmacological interventions for alleviating pain during orthodontic treatment[J]. Cochrane Database Syst Rev，2016，12（12）：CD010263. DOI：10.1002/14651858.CD010263.pub2.
[46]	Deana NF，Zaror C，Sandoval P，et al. Effectiveness of low-level laser therapy in reducing orthodontic pain：A systematic review and meta-analysis[J]. Pain Res Manag，2017：8560652. DOI：10.1155/2017/8560652.
[47]	Badiee M，Tehranchi A，Behnia P，et al. Efficacy of low-intensity pulsed ultrasound for orthodontic pain control：A randomized clinical trial[J]. Front Dent，2021，18：38. DOI：10.18502/fid.v18i38.7607.
[48]	Alazzawi MMJ，Husein A，Alam MK，et al. Effect of low level laser and low intensity pulsed ultrasound therapy on bone remodeling during orthodontic tooth movement in rats[J]. Prog Orthod，2018，19（1）：10. DOI：10.1186/s40510-018-0208-2.
[49]	Zhu Y，Wang S，Long H，et al. Effect of static magnetic field on pain level and expression of P2X3 receptors in the trigeminal ganglion in mice following experimental tooth movement[J]. Bioelectromagnetics，2017，38（1）：22-30. DOI：10.1002/bem.22009.
[50]	Ishida Y，Kuwajima Y，Ogawa K，et al. 3D digital analysis of tooth movement with magnets and elastics in vitro[J]. Heliyon，2021，7（7）：e07507. DOI：10.1016/j.heliyon.2021.e07507.
[51]	梁爱燕，王大为.稀土永磁体在正畸中的研究及应用进展[J/OL].中华口腔医学研究杂志（电子版），2009，3（6）：675-679. DOI：10.3969/j.issn.1674-1366.2009.06.019.
[52]	Polat O，Karaman AI. Pain control during fixed orthodontic appliance therapy[J]. Angle Orthod，2005，75（2）：214-219. DOI：10.1043/0003-3219(2005)075<0210:PCDFOA>2.0.CO;2.
[53]	Lobre WD，Callegari BJ，Gardner G，et al. Pain control in orthodontics using a micropulse vibration device：A randomized clinical trial[J]. Angle Orthod，2016，86（4）：625-630. DOI：10.2319/072115-492.1.
[54]	Alshammari AK，Huggare J. Pain relief after orthodontic archwire installation-a comparison between intervention with paracetamol and chewing gum：A randomized controlled trial[J]. Eur J Orthod，2019，41（5）：478-485. DOI：10.1093/ejo/cjy081.
[55]	Peng Y，Tang S. The factors affecting orthodontic pain with periodontitis[J]. J Healthc Eng，2021：8942979. DOI：10.1155/2021/8942979.
[56]	贾莹，陈波，蔡绍祥，等.经皮穴位电刺激对家兔正畸牙痛的防治作用[J].中国针灸，2016，338（11）：1186-1190. DOI：10.13703/j.0255-2930.2016.11.021.
[57]	Haralambidis C. Pain-free orthodontic treatment with the dental pain eraser[J]. J Clin Orthod，2019，53（4）：234-242.
[58]	Noma N，Watanabe Y，Shimada A，et al. Effects of cognitive behavioral therapy on orofacial pain conditions[J]. J Oral Sci，2020，63（1）：4-7. DOI：10.2334/josnusd.20-0437.
[59]	Furman E，Jasinevicius TR，Bissada NF，et al. Virtual reality distraction for pain control during periodontal scaling and root planing procedures[J]. J Am Dent Assoc，2009，140（12）：1508-1516. DOI：10.14219/jada.archive.2009.0102.

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