Research progress of microRNA-21 as the biomarker in oral squamous cell carcinoma

doi:10.3877/cma.j.issn.1674-1366.2022.05.011

Abstract

Abstract:

Oral squamous cell carcinoma (OSCC) is one of the most common malignant tumors in the head and neck regions. The diagnosis and treatment for OSCC are still unsatisfactory. It has been shown that microRNAs are abnormally expressed in many malignant tumors, including OSCC. Abundant evidence suggests that microRNA-21 (miR-21) plays an important role in the development of OSCC, and its abnormal expression can act as an important basis for early diagnosis and prognosis assessment of patients. This paper reviews the research progress of miR-21 functions in OSCC, which demonstrates that miR-21 may be used as a diagnostic and prognostic biomarker for OSCC patients and worth further efforts for clinical translations.

Key words: Carcinoma, squamous cell, miRNAs, Biomarkers

Weitao Hu, Xinghan Li, Qi Liu, He Meng, Lin Ma, Yongqiang Deng. Research progress of microRNA-21 as the biomarker in oral squamous cell carcinoma[J]. Chinese Journal of Stomatological Research(Electronic Edition), 2022, 16(05): 328-332.

/ / Recommend

Add to citation manager EndNote|Ris|BibTeX

URL: https://zhkqyxyjzz.cma-cmc.com.cn/EN/10.3877/cma.j.issn.1674-1366.2022.05.011

https://zhkqyxyjzz.cma-cmc.com.cn/EN/Y2022/V16/I05/328

Figures/Tables 2

References 53

[1]	Cristaldi M，Mauceri R，Di Fede O，et al. Salivary biomarkers for oral squamous cell carcinoma diagnosis and follow-up：Current status and perspectives[J]. Front Physiol，2019，10：1476. DOI：10.3389/fphys.2019.01476.
[2]	Panarese I，Aquino G，Ronchi A，et al. Oral and Oropharyngeal squamous cell carcinoma：Prognostic and predictive parameters in the etiopathogenetic route[J]. Expert Rev Anticancer Ther，2019，19（2）：105-119. DOI：10.1080/14737140.2019.1561288.
[3]	Sung H，Ferlay J，Siegel RL，et al. Global cancer statistics 2020：GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries[J]. CA Cancer J Clin，2021，71（3）：209-249. DOI：10.3322/caac.21660.
[4]	陈新，徐文华，周健，等.口腔鳞状细胞癌现状[J].口腔医学，2017，37（5）：462-465. DOI：10.13591/j.cnki.kqyx.2017.05.018.
[5]	Bloebaum M，Poort L，Böckmann R，et al. Survival after curative surgical treatment for primary oral squamous cell carcinoma[J]. J Craniomaxillofac Surg，2014，42（8）：1572-1576. DOI：10.1016/j.jcms.2014.01.046.
[6]	Nandini DB，Rao RS，Hosmani J，et al. Novel therapies in the management of oral cancer：An update[J]. Dis Mon，2020，66（12）：101036. DOI：10.1016/j.disamonth.2020.101036.
[7]	Bavle RM，Venugopal R，Konda P，et al. Molecular classification of oral squamous cell carcinoma[J]. J Clin Diagn Res，2016，10（9）：ZE18-ZE21. DOI：10.7860/JCDR/2016/19967.8565.
[8]	Wang B，Zhang S，Yue K，et al. The recurrence and survival of oral squamous cell carcinoma：A report of 275 cases[J]. Chin J Cancer，2013，32（11）：614-618. DOI：10.5732/cjc.012.10219.
[9]	Chow LQM. Head and neck cancer[J]. N Engl J Med，2020，382（1）：60-72. DOI：10.1056/NEJMra1715715.
[10]	Bartel DP. MicroRNAs：genomics，biogenesis，mechanism，and function[J]. Cell，2004，116（2）：281-297. DOI：10.1016/s0092-8674(04)00045-5
[11]	Saliminejad K，Khorram Khorshid HR，Soleymani Fard S，et al. An overview of microRNAs：Biology，functions，therapeutics，and analysis methods[J]. J Cell Physiol，2019，234（5）：5451-5465. DOI：10.1002/jcp.27486.
[12]	Ha M，Kim VN. Regulation of microRNA biogenesis[J]. Nat Rev Mol Cell Biol，2014，15（8）：509-524. DOI：10.1038/nrm3838.
[13]	Perera RJ，Ray A. MicroRNAs in the search for understanding human diseases[J]. BioDrugs，2007，21（2）：97-104. DOI：10.2165/00063030-200721020-00004.
[14]	Menderico Junior GM，Thérèse TR，Pasini FS，et al. MicroRNA-mediated extracellular matrix remodeling in squamous cell carcinoma of the oral cavity[J]. Head Neck，2021，43（8）：2364-2376. DOI：10.1002/hed.26686.
[15]	Hedbäck N，Jensen DH，Specht L，et al. MiR-21 expression in the tumor stroma of oral squamous cell carcinoma：An independent biomarker of disease free survival[J]. PLoS One，2014，9（4）：e95193. DOI：10.1371/journal.pone.0095193.
[16]	Mahmood N，Hanif M，Ahmed A，et al. Circulating miR-21 as a prognostic and predictive biomarker in oral squamous cell carcinoma[J]. Pak J Med Sci，2019，35（5）：1408-1412. DOI：10.12669/pjms.35.5.331.
[17]	Ren W，Qiang C，Gao L，et al. Circulating microRNA-21（MIR-21）and phosphatase and tensin homolog（PTEN）are promising novel biomarkers for detection of oral squamous cell carcinoma[J]. Biomarkers，2014，19（7）：590-596. DOI：10.3109/1354750X.2014.955059.
[18]	吴淋蓉，郝文娟，刘伟红，等. miR-21在头颈肿瘤中的研究进展[J].中国细胞生物学学报，2018，40（8）：1438-1444. DOI：10.11844/cjcb.2018.08.0060.
[19]	Feng YH，Tsao CJ. Emerging role of microRNA-21 in cancer [J]. Biomed Rep，2016，5（4）：395-402. DOI：10.3892/br.2016.747.
[20]	Tseng HH，Tseng YK，You JJ，et al. Next-generation sequencing for microRNA profiling：microRNA-21-3p promotes oral cancer metastasis[J]. Anticancer Res，2017，37（3）：1059-1066. DOI：10.21873/anticanres.11417.
[21]	Hanahan D，Weinberg RA. Hallmarks of cancer：The next generation[J]. Cell，2011，144（5）：646-674. DOI：10.1016/j.cell.2011.02.013.
[22]	Grivennikov SI，Karin M. Inflammatory cytokines in cancer：Tumour necrosis factor and interleukin 6 take the stage[J]. Ann Rheum Dis，2011，70 Suppl 1：i104-i108. DOI：10.1136/ard.2010.140145.
[23]	Xi J，Huang Q，Wang L，et al. miR-21 depletion in macrophages promotes tumoricidal polarization and enhances PD-1 immunotherapy[J]. Oncogene，2018，37（23）：3151-3165. DOI：10.1038/s41388-018-0178-3.
[24]	He Q，Chen Z，Dong Q，et al. MicroRNA-21 regulates prostaglandin E2 signaling pathway by targeting 15-hydroxyprostaglandin dehydrogenase in tongue squamous cell carcinoma[J]. BMC Cancer，2016，16（1）：685. DOI：10.1186/s12885-016-2716-0.
[25]	Pastushenko I，Blanpain C. EMT transition states during tumor progression and metastasis[J]. Trends Cell Biol，2019，29（3）：212-226. DOI：10.1016/j.tcb.2018.12.001.
[26]	Ma C，Shi T，Qu Z，et al. CircRNA_ACAP2 suppresses EMT in head and neck squamous cell carcinoma by targeting the miR-21-5p/STAT3 signaling axis[J]. Front Oncol，2020，10：583682. DOI：10.3389/fonc.2020.583682.
[27]	Zeng B，Li Y，Jiang F，et al. LncRNA GAS5 suppresses proliferation，migration，invasion，and epithelial-mesenchymal transition in oral squamous cell carcinoma by regulating the miR-21/PTEN axis[J]. Exp Cell Res，2019，374（2）：365-373. DOI：10.1016/j.yexcr.2018.12.014.
[28]	Lu X，Kang Y. Hypoxia and hypoxia-inducible factors：Master regulators of metastasis[J]. Clin Cancer Res，2010，16（24）：5928-5935. DOI：10.1016/j.trecan.2016.10.016.
[29]	Ren W，Hou J，Yang C，et al. Extracellular vesicles secreted by hypoxia pre-challenged mesenchymal stem cells promote non-small cell lung cancer cell growth and mobility as well as macrophage M2 polarization via miR-21-5p delivery[J]. J Exp Clin Cancer Res，2019，38（1）：62. DOI：10.1186/s13046-019-1027-0.
[30]	Li L，Li C，Wang S，et al. Exosomes derived from hypoxic oral squamous cell carcinoma cells deliver miR-21 to normoxic cells to elicit a prometastatic phenotype[J]. Cancer Res，2016，76（7）：1770-1780. DOI：10.1158/0008-5472.CAN-15-1625.
[31]	Karimi A，Bahrami N，Sayedyahossein A，et al. Evaluation of circulating serum 3 types of microRNA as biomarkers of oral squamous cell carcinoma；A pilot study[J]. J Oral Pathol Med，2020，49（1）：43-48. DOI：10.1111/jop.12959.
[32]	Singh P，Srivastava AN，Sharma R，et al. Circulating microRNA-21 expression as a novel serum biomarker for oral sub-mucous fibrosis and oral squamous cell carcinoma[J]. Asian Pac J Cancer Prev，2018，19（4）：1053-1057. DOI：10.22034/APJCP.2018.19.4.1053.
[33]	Ishinaga H，He F，Hou B，et al. A longitudinal study on circulating miR-21 as a therapeutic effect marker in head and neck squamous cell carcinoma[J]. Carcinogenesis，2019：bgz075. DOI：10.1093/carcin/bgz075.
[34]	Rapado-González Ó，López-López R，López-Cedrún JL，et al. Cell-Free microRNAs as potential oral cancer biomarkers：From diagnosis to therapy[J]. Cells，2019，8（12）：1653. DOI：10.3390/cells8121653.
[35]	Al Rawi N，Elmabrouk N，Abu Kou R，et al. The role of differentially expressed salivary microRNA in oral squamous cell carcinoma. A systematic review[J]. Arch Oral Biol，2021，125：105108. DOI：10.1016/j.archoralbio.2021.105108.
[36]	顾小军，王腾勇，刘新庆，等. miRNA-21在口腔鳞癌患者唾液中的表达及意义[J].口腔颌面外科杂志，2016，26（5）：323-327. DOI：10.3969/j.issn.1005-4979.2016.05.004.
[37]	Zahran F，Ghalwash D，Shaker O，et al. Salivary microRNAs in oral cancer[J]. Oral Dis，2015，21（6）：739-747. DOI：10.1111/odi.12340.
[38]	Mehdipour M，Shahidi M，Manifar S，et al. Diagnostic and prognostic relevance of salivary microRNA-21，-125a，-31 and - 200a levels in patients with oral lichen planus：A short report [J]. Cell Oncol（Dordr），2018，41（3）：329-334. DOI：10.1007/s13402-018-0372-x.
[39]	Uma Maheswari TN，Nivedhitha MS，Ramani P. Expression profile of salivary micro RNA-21 and 31 in oral potentially malignant disorders[J]. Braz Oral Res，2020，34：e002. DOI：10.1590/1807-3107bor-2020.vol34.0002.
[40]	Yap T，Koo K，Cheng L，et al. Predicting the presence of oral squamous cell carcinoma using commonly dysregulated microrna in oral swirls[J]. Cancer Prev Res（Phila），2018，11（8）：491-502. DOI：10.1158/1940-6207.CAPR-17-0409.
[41]	Yap T，Seers C，Koo K，et al. Non-invasive screening of a microRNA-based dysregulation signature in oral cancer and oral potentially malignant disorders[J]. Oral Oncol，2019，96：113-120. DOI：10.1016/j.oraloncology.2019.07.013.
[42]	Liu C，Tong Z，Tan J，et al. MicroRNA-21-5p targeting PDCD4 suppresses apoptosis via regulating the PI3K/AKT/FOXO1 signaling pathway in tongue squamous cell carcinoma[J]. Exp Ther Med，2019，18（5）：3543-3551. DOI：10.3892/etm.2019.7970.
[43]	Lopes CB，Magalhães LL，Teófilo CR，et al. Differential expression of hsa-miR-221，hsa-miR-21，hsa-miR-135b，and hsa-miR-29c suggests a field effect in oral cancer[J]. BMC Cancer，2018，18（1）：721. DOI：10.1186/s12885-018-4631-z.
[44]	Manikandan M，Deva Magendhra Rao AK，Rajkumar KS，et al. Altered levels of miR-21，miR-125b-2^*，miR-138，miR-155，miR-184，and miR-205 in oral squamous cell carcinoma and association with clinicopathological characteristics[J]. J Oral Pathol Med，2015，44（10）：792-800. DOI：10.1111/jop.12300.
[45]	Li J，Huang H，Sun L，et al. MiR-21 indicates poor prognosis in tongue squamous cell carcinomas as an apoptosis inhibitor[J]. Clin Cancer Res，2009，15（12）：3998-4008. DOI：10.1158/1078-0432.CCR-08-3053.
[46]	Rajan C，Roshan VGD，Khan I，et al. MiRNA expression profiling and emergence of new prognostic signature for oral squamous cell carcinoma[J]. Sci Rep，2021，11（1）：7298. DOI：10.1038/s41598-021-86316-w.
[47]	Supic G，Zeljic K，Rankov AD，et al. miR-183 and miR-21 expression as biomarkers of progression and survival in tongue carcinoma patients[J]. Clin Oral Investig，2018，22（1）：401-409. DOI：10.1007/s00784-017-2126-y.
[48]	Liu KYP，Zhu SY，Brooks D，et al. Tumor microRNA profile and prognostic value for lymph node metastasis in oral squamous cell carcinoma patients[J]. Oncotarget，2020，11（23）：2204-2215. DOI：10.18632/oncotarget.27616.
[49]	Chen Z，Yu T，Cabay RJ，et al. miR-486-3p，miR-139-5p，and miR-21 as biomarkers for the detection of oral tongue squamous cell carcinoma[J]. Biomark Cancer，2017，9：1179299X170090 0001. DOI：10.1177/1179299X1700900001.
[50]	Yu EH，Tu HF，Wu CH，et al. MicroRNA-21 promotes perineural invasion and impacts survival in patients with oral carcinoma[J]. J Chin Med Assoc，2017，80（6）：383-388. DOI：10.1016/j.jcma.2017.01.003.
[51]	Wan Y，Hoyle RG，Xie N，et al. A super-enhancer driven by FOSL1 controls miR-21-5p expression in head and neck squamous cell carcinoma[J]. Front Oncol，2021，11：656628. DOI：10.3389/fonc.2021.656628.
[52]	Rapado-González O，Martínez-Reglero C，Salgado-Barreira A，et al. miRNAs in liquid biopsy for oral squamous cell carcinoma diagnosis：Systematic review and meta-analysis[J]. Oral Oncol，2019，99：104465. DOI：10.1016/j.oraloncology.2019.104465.
[53]	Gigliotti J，Madathil S，Makhoul N. Delays in oral cavity cancer [J]. Int J Oral Maxillofac Surg，2019，48（9）：1131-1137. DOI：10.1016/j.ijom.2019.02.015.

调节作用	相关通路	参考文献
降低肿瘤免疫抑制	JAK3/STAT1	[23]
调节肿瘤炎性因子	PEG₂	[24]
促进肿瘤细胞EMT	STAT3	[26]
促进肿瘤侵袭转移	GAS5	[27]
加强肿瘤缺氧后的侵袭转移能力	HIF	[29，30]

调节作用	相关通路	参考文献
降低肿瘤免疫抑制	JAK3/STAT1	[23]
调节肿瘤炎性因子	PEG₂	[24]
促进肿瘤细胞EMT	STAT3	[26]
促进肿瘤侵袭转移	GAS5	[27]
加强肿瘤缺氧后的侵袭转移能力	HIF	[29，30]

Please choose a citation manager

Content to export