Advances in diagnosis and treatment of sialadenitis associated with thyroid cancer after 131I therapy

doi:10.3877/cma.j.issn.1674-1366.2022.03.012

Abstract

Abstract:

¹³¹I-related sialadenitis is a common complication after thyroid cancer ¹³¹I treatment, and its main mechanism is not yet fully understood. Studies suggest that the absorption of iodine by the sodium-iodine symporter (NIS) of salivary gland duct epithelial cells leads to acute or chronic inflammation of the duct. The latest research results show that it may also be related to aquaporin (AQP) . The clinical manifestations and treatment plan of ¹³¹I-related sialadenitis are basically equivalent to conventional acute and chronic sialadenitis, and prevention is the main clinical treatment. This article reviews the recent research progress on the pathology, physiology, diagnosis and treatment of ¹³¹I-related sialadenitis.

Key words: Salivary adenitis, Iodine radioisotopes, Thyroid cancer

Jiaxiong Zhao, Xinrong Nan, Bing Meng, Ruifang Li, Xingquan Yan. Advances in diagnosis and treatment of sialadenitis associated with thyroid cancer after ¹³¹I therapy[J]. Chinese Journal of Stomatological Research(Electronic Edition), 2022, 16(03): 199-202.

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References 36

[1]	Ehrhardt JD Jr, Gulec SA. Birth of the beta-knife thyroidectomy：The radiance of saul hertz [J]. Am Surg，2022:313482110604 63. DOI：10.1177/00031348211060463.
[2]	Sánchez Barrueco A, González Galán F, Alcalá Rueda I，et al. Incidence and risk factors for radioactive iodine-induced sialadenitis[J]. Acta Otolaryngol，2020，140(11):959-962. DOI：10.1080/00016489.2020.1802507.
[3]	Yasmin T, Adnan S, Younis MN，et al. Comparing high and low-dose radio-iodine therapy in thyroid remnant ablation among intermediate and low-risk papillary thyroid carcinoma patients-single centre experience[J]. Dose Response，2021，19(4):155 93258211062775. DOI：10.1177/15593258211062775.
[4]	Lei L, Velasco O, Nobay F. Iodide mumps：A case report of complicated radioactive iodine causing sialadenitis[J]. Am J Emerg Med，2012，30(3):512.e5-512.e6. DOI：10.1016/j.ajem.2010.12.037.
[5]	Nabaa B, Takahashi K, Sasaki T，et al. Assessment of salivary gland dysfunction after radioiodine therapy for thyroid carcinoma using non-contrast-enhanced CT：The significance of changes in volume and attenuation of the glands[J]. Am J Neuroradiol，2012，33(10):1964-1970. DOI：10.3174/ajnr.A3063.
[6]	Thorpe RK, Foggia MJ, Marcus KS，et al. Sialographic analysis of radioiodine-associated chronic sialadenitis[J]. Laryngoscope，2021，131(5):E1450-E1456. DOI：10.1002/lary.29279.
[7]	Lu L, Shan F, Li W，et al. Short-term side effects after radioiodine treatment in patients with differentiated thyroid cancer[J]. Biomed Res Int，2016:4376720. DOI：10.1155/2016/4376720.
[8]	Oh JM, Kalimuthu S, Gangadaran P，et al. Reverting iodine avidity of radioactive-iodine refractory thyroid cancer with a new tyrosine kinase inhibitor（K905-0266）excavated by high-throughput NIS（sodium iodide symporter）enhancer screening platform using dual reporter gene system[J]. Oncotarget，2018，9(6):7075-7087. DOI：10.18632/oncotarget.24159.
[9]	Prendes BL, Orloff LA, Eisele DW. Therapeutic sialendoscopy for the management of radioiodine sialadenitis[J]. Arch Otolaryngol Head Neck Surg，2012，138(1):15-19. DOI：10.1001/archoto.2011.215.
[10]	Geres AE, Mereshian PS, Fernández S，et al. Sialadenitis after radioiodine therapy. Analysis of factors that influence the response to medical treatment[J]. Endocrinol Nutr，2015，62(10):493-498. DOI：10.1016/j.endonu.2015.07.006.
[11]	Wu CB, Xi H, Zhou Q，et al. Sialendoscopy-assisted treatment for radioiodine-induced sialadenitis[J]. J Oral Maxillofac Surg，2015，73(3):475-481. DOI：10.1016/j.joms.2014.09.025.
[12]	李审绥，吴沉洲，乔翔鹤，等.辐射损伤唾液腺机制及治疗的研究进展[J].华西口腔医学杂志，2021，39(1):99-104. DOI：10.7518/hxkq.2021.01.015.
[13]	Peng X, Wu Y, Brouwer U，et al. Cellular senescence contributes to radiation-induced hyposalivation by affecting the stem/progenitor cell niche[J]. Cell Death Dis，2020，11(10):854. DOI：10.1038/s41419-020-03074-9.
[14]	Gonzalez ME, Muttikkal TJE, Rehm PK. Sialadenitis following low dose I-131 diagnostic thyroid scan with Thyrogen^®（recombinant human thyroid stimulating hormone-thyrotropin alfa）[J]. J Radiol Case Rep，2015，9(6):44-49. DOI：10.3941/jrcr.v9i6.2220.
[15]	Katada R, Tanaka J, Takamatsu K，et al. Induction of salivary gland-like cells from epithelial tissues transdifferentiated from mouse embryonic fibroblasts[J]. Biochem Biophys Res Commun，2022，586:55-62. DOI：10.1016/j.bbrc.2021.11.064.
[16]	Feng X, Wu Z, Xu J，et al. Dietary nitrate supplementation prevents radiotherapy-induced xerostomia[J]. Elife，2021，10:e70710. DOI：10.7554/eLife.70710.
[17]	Klein Hesselink EN, Brouwers AH, de Jong JR，et al. Effects of radioiodine treatment on salivary gland function in patients with differentiated thyroid carcinoma：A prospective study[J]. J Nucl Med，2016，57(11):1685-1691. DOI：10.2967/jnumed.115.169888.
[18]	Mizrachi A, Cotrim AP, Katabi N，et al. Radiation-induced microvascular injury as a mechanism of salivary gland hypofunction and potential target for radioprotectors[J]. Radiat Res，2016，186(2):189-195. DOI：10.1667/RR14431.1.
[19]	Cotrim AP, Sowers A, Mitchell JB，et al. Prevention of irradiation-induced salivary hypofunction by microvessel protection in mouse salivary glands[J]. Mol Ther，2007，15(12):2101-2106. DOI：10.1038/sj.mt.6300296.
[20]	Xu J, Yan X, Gao R，et al. Effect of irradiation on microvascular endothelial cells of parotid glands in the miniature pig[J]. Int J Radiat Oncol Biol Phys，2010，78(3):897-903. DOI：10.1016/j.ijrobp.2010.05.048.
[21]	Liu Z, Dong L, Zheng Z，et al. Mechanism，prevention，and treatment of radiation-induced salivary gland injury related to oxidative stress[J]. Antioxidants（Basel），2021，10(11):1666. DOI：10.3390/antiox10111666.
[22]	Yamazaki H, Suzuki G, Aibe N，et al. Reirradiation for rare head and neck cancers：Orbit，auditory organ，and salivary glands[J]. Cureus，2022，14(2):e22727. DOI：10.7759/cureus.22727.
[23]	Moloney EC, Brunner M, Alexander AJ，et al. Quantifying fibrosis in head and neck cancer treatment：An overview[J]. Head Neck，2015，37(8):1225-1231. DOI：10.1002/hed.23722.
[24]	Lalkovicova M. Neuroprotective agents effective against radiation damage of central nervous system[J]. Neural Regen Res，2022，17(9):1885-1892. DOI：10.4103/1673-5374.335137.
[25]	An YS, Yoon JK, Lee SJ，et al. Symptomatic late-onset sialadenitis after radioiodine therapy in thyroid cancer[J]. Ann Nucl Med，2013，27(4):386-391. DOI：10.1007/s12149-013-0697-5.
[26]	Krčálová E, Horáček J, Gabalec F，et al. Scintigraphic evaluation of salivary gland function in thyroid cancer patients after radioiodine remnant ablation[J]. Eur J Oral Sci，2020，128(3):204-210. DOI：10.1111/eos.12689.
[27]	Singer MC, Marchal F, Angelos P，et al. Salivary and lacrimal dysfunction after radioactive iodine for differentiated thyroid cancer：American Head and Neck Society Endocrine Surgery Section and Salivary Gland Section joint multidisciplinary clinical consensus statement of otolaryngology，ophthalmology，nuclear medicine and endocrinology[J]. Head Neck，2020，42(11):3446-3459. DOI：10.1002/hed.26417.
[28]	Son H, Lee SM, Yoon RG，et al. Effect of selenium supplementation for protection of salivary glands from iodine-131 radiation damage in patients with differentiated thyroid cancer[J]. Hell J Nucl Med，2017，20(1):62-70. DOI：10.1967/s002449910508.
[29]	Choi JS, Hong SB, Hyun IY，et al. Effects of salivary secretion stimulation on the treatment of chronic radioactive iodine-induced sialadenitis[J]. Thyroid，2015，25(7):839-845. DOI：10.1089/thy.2014.0525.
[30]	Gil-Montoya JA, Silvestre FJ, Barrios R，et al. Treatment of xerostomia and hyposalivation in the elderly：A systematic review[J]. Med Oral Patol Oral Cir Bucal，2016，21(3):e355-e366. DOI：10.4317/medoral.20969.
[31]	Karagozoglu KH, Vissink A, Forouzanfar T，et al. Sialendoscopy increases saliva secretion and reduces xerostomia up to 60 weeks in Sjögren′s syndrome patients：A randomized controlled study[J]. Rheumatology（Oxford），2021，60(3):1353-1363. DOI：10.1093/rheumatology/keaa284.
[32]	Jentzen W, Richter M, Nagarajah J，et al. Chewing-gum stimulation did not reduce the absorbed dose to salivary glands during radioiodine treatment of thyroid cancer as inferred from pre-therapy ¹²⁴I PET/CT imaging[J]. EJNMMI Phys，2014，1(1):100. DOI：10.1186/s40658-014-0100-1.
[33]	Zhang T, Liu C, Ma S，et al. Protective effect and mechanism of action of rosmarinic acid on radiation-induced parotid gland injury in rats[J]. Dose Response，2020，18(1):15593258209 07782. DOI：10.1177/1559325820907782.
[34]	Li X, Zhao YN, Zhang LQ，et al. Differences between radioactive iodine-induced sialadenitis and chronic obstructive parotitis[J]. Int J Oral Maxillofac Surg，2021:S0901-5027(21)00391-X. DOI：10.1016/j.ijom.2021.11.003.
[35]	Liu X, Cotrim A, Teos L，et al. Loss of TRPM2 function protects against irradiation-induced salivary gland dysfunction[J]. Nat Commun，2013，4:1515. DOI：10.1038/ncomms2526.
[36]	Timiri Shanmugam PS, Dayton RD, Palaniyandi S，et al. Recombinant AAV9-TLK1B administration ameliorates fractionated radiation-induced xerostomia[J]. Hum Gene Ther，2013，24(6):604-612. DOI：10.1089/hum.2012.235.

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