Application of metagenomics in the study of oral diseases based on the flora changes of oral-gut axis

doi:10.3877/cma.j.issn.1674-1366.2022.03.011

Abstract

Abstract:

Using genomics techniques and strategies, metagenomics can be used to study the genetic composition and colony function of all microbiotas contained in environmental samples, which effectively break through the limitations of conventional microbiology culture and might provide new ideas or methods for the overall study of microbial communities in the body. The oral cavity and intestinal tract are important parts of the human body where a large number of microbial communities inhabit. Under normal condition, the microbial communities maintain local homeostasis in a healthy situation. However, the dysbacteriosis from oral-gut axis can not only lead to local tissue lesions in oral and intestine tract, but also might contribute to the pathological progress in other systems through the oral-gut axis. In recent years, metagenomics has been widely used to detect the composition and functional changes of microbial flora related to the oral-intestinal axis and analyze the possible role of dysbacteriosis in oral diseases. Hopefully, it can provide a new perspective for the study of pathogenesis of oral related diseases. This article reviewed the application of metagenomics in oral diseases related to the oral-gut axis.

Key words: Metagenomics, Oral-gut axis, Microbiota, Oral diseases

Han Zhang, Yafang Liu, Junying Yang. Application of metagenomics in the study of oral diseases based on the flora changes of oral-gut axis[J]. Chinese Journal of Stomatological Research(Electronic Edition), 2022, 16(03): 194-198.

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