Expression and clinical significance of interleukin-7 in the salivary glands of patients with primary Sjögren′s syndrome

doi:10.3877/cma.j.issn.1674-1366.2020.05.003

Chinese Journal of Stomatological Research(Electronic Edition) ›› 2020, Vol. 14 ›› Issue (05): 288-293. doi: 10.3877/cma.j.issn.1674-1366.2020.05.003

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Expression and clinical significance of interleukin-7 in the salivary glands of patients with primary Sjögren′s syndrome

Yujiao Lin¹, Yukai Wang², Youshan Wang¹, Yiwen Xie¹^,^†()

^1. Department of Stomatology, Shantou Central Hospital, Shantou 515031, China
^2. Department of Rheumatology and Immunology, Shantou Central Hospital, Shantou 515031, China

Received:2020-05-12 Online:2020-10-01 Published:2020-10-01
Contact: Yiwen Xie
About author:
Corresponding author: Xie Yiwen, Email: 164854536@qq.com
Supported by:
Medical Scientific Research Foundation of Guangdong Province(A2019244); Medical Health Science and Technology Projects of Shantou(2015-123-07 and 2019-106-21)

Abstract

Abstract:

Objective

To investigate the expression of interleukin-7 (IL-7) in the labial glands and its correlation with the clinical serum biomarkers in the patients with primary Sj?gren′s syndrome.

Methods

A total of 135 patients with pSS from the Department of Rheumatology and Immunology of Shantou Central Hospital from January 2015 to December 2017 were recruited, while 12 normal individuals in the same period were included as control. Immunohistochemical method was used to detect the expression level of IL-7 in the glandular epithelial cells and infiltrated lymphocytes. The relationships between IL-7 and serum ANA, C3, C4, CRP and IgG were investigated.

Results

IL-7 was highly expressed in the epithelial cells and lymphocytes infiltrated in the pSS salivary glands. The positive expression of IL-7 in the pSS patients (88.14%, 119/135) was significantly higher than that in the control (8.3%, 1/12; χ² = 46.82, P<0.001) . The expression of IL-7 in the infiltrated lymphocytes was positively correlated with that in the epithelial cells (r = 0.27, P = 0.0012) , while no correlation with the serum biomarkers, including ANA, C3, C4, CRP and IgG was found.

Conclusions

The increased expression of IL-7 in the glandular epithelial cells in patients with pSS was related to its expression in infiltrated lymphocytes, indicating a crosstalk between epithelial cells and lymphocytes in the immunopathology of pSS. IL-7 can be a therapeutic target for pSS.

Key words: Sj?gren′s syndrome, Interleukin-7, Salivary glands, Labial

Yujiao Lin, Yukai Wang, Youshan Wang, Yiwen Xie. Expression and clinical significance of interleukin-7 in the salivary glands of patients with primary Sjögren′s syndrome[J]. Chinese Journal of Stomatological Research(Electronic Edition), 2020, 14(05): 288-293.

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