Research progress on the study of the interaction and mechanism between periodontitis and chronic kidney disease

doi:10.3877/cma.j.issn.1674-1366.2019.02.010

Abstract

Abstract:

Periodontitis is a chronic inflammatory condition that occurs in the periodontal supporting tissue, which is one of the main reasons for the loss of teeth among adults. Chronic kidney disease (CKD) is considered as a global public health problem in the 21st century, and ranked the third top healthy killer only after cancer and heart attack. At present, a large number of studies have found that periodontitis and chronic kidney disease are closely related. Moderate evidence indicates that periodontitis has a certain impact on chronic kidney disease. Evidence for the opposite direction is extremely weak, while the two diseases may be risk factors for each other. For patients with chronic kidney disease complicated with periodontitis, the implementation of periodontal intervention treatment can help reduce the burden of inflammation and improve nutritional status of patients, which can contribute to good prognosis. Until now, few studies focus on the effect of periodontal therapy on renal function in patients with chronic kidney disease, and no definite conclusions have been drawn.This review introduces the progress of the research on the interaction between periodontitis and chronic kidney disease as well as its pathogenesis in recent years. We also discuss the existing problems and the future work on it.

Key words: Periodontitis, Kidney disease, chronic, Risk factors, Pathogenesis

Hongyu Wu, Wei Ye, Haixia Lu. Research progress on the study of the interaction and mechanism between periodontitis and chronic kidney disease[J]. Chinese Journal of Stomatological Research(Electronic Edition), 2019, 13(02): 119-123.

/ / Recommend

Add to citation manager EndNote|Ris|BibTeX

URL: https://zhkqyxyjzz.cma-cmc.com.cn/EN/10.3877/cma.j.issn.1674-1366.2019.02.010

https://zhkqyxyjzz.cma-cmc.com.cn/EN/Y2019/V13/I02/119

References 45

[1]	Zhang L, Wang F, Wang L，et al. Prevalence of chronic kidney disease in China：a cross-sectional survey[J]. Lancet，2012，379(9818):815-822. DOI：10.1016/S0140-6736(12)60033-6.
[2]	Pihlstrom BL, Michalowicz BS, Johnson NW. Periodontal diseases [J]. Lancet，2005，366(9499):1809-1820. DOI：10.1016/S0140-6736(05)67728-8.
[3]	Dietrich T, Sharma P, Walter C，et al. The epidemiological evidence behind the association between periodontitis and incident atherosclerotic cardiovascular disease[J]. J Periodontol，2013，84(4 Suppl):S70-S84. DOI：10.1902/jop.2013.134008.
[4]	Schomig M, Eisenhardt A, Ritz E. The microinflammatory state of uremia[J]. Blood Purif，2000，18(4):327-332. DOI：10.1159/000014457.
[5]	Akram Z, Abduljabbar T, Abu Hassan MI，et al. Cytokine Profile in Chronic Periodontitis Patients with and without Obesity：A Systematic Review and Meta-Analysis[J]. Dis Markers，2016(20162):4801418. DOI：10.1155/2016/4801418.
[6]	Kshirsagar AV, Moss KL, Elter JR，et al. Periodontal disease is associated with renal insufficiency in the Atherosclerosis Risk In Communities（ARIC）study[J]. Am J Kidney Dis，2005，45(4):650-657. DOI：10.1053/j.ajkd.2004.12.009.
[7]	Kshirsagar AV, Craig RG, Beck JD，et al. Severe periodontitis is associated with low serum albumin among patients on maintenance hemodialysis therapy[J]. Clin J Am Soc Nephrol，2007，2(2):239-244. DOI：10.2215/CJN.02420706.
[8]	Fisher MA, Taylor GW, West BT，et al. Bidirectional relationship between chronic kidney and periodontal disease：a study using structural equation modeling[J]. Kidney Int，2011，79(3):347-355. DOI：10.1038/ki.2010.384.
[9]	Han SS, Shin N, Lee SM，et al. Correlation between periodontitis and chronic kidney disease in Korean adults[J]. Kidney Res Clin Pract，2013，32(4):164-170. DOI：10.1016/j.krcp.2013.09.001.
[10]	Liu K, Liu Q, Chen W，et al. Prevalence and risk factors of CKD in Chinese patients with periodontal disease[J]. PLoS One，2013，8(8):e70767. DOI：10.1371/journal.pone.0070767.
[11]	Iwasaki M, Taylor GW, Nesse W，et al. Periodontal disease and decreased kidney function in Japanese elderly[J]. Am J Kidney Dis，2012，59(2):202-209. DOI：10.1053/j.ajkd.2011.08.027.
[12]	Chen YT, Shih CJ, Ou SM，et al. Periodontal Disease and Risks of Kidney Function Decline and Mortality in Older People：A Community-Based Cohort Study[J]. Am J Kidney Dis，2015，66(2):223-230. DOI：10.1053/j.ajkd.2015.01.010.
[13]	Grubbs V, Vittinghoff E, Beck JD，et al. Association Between Periodontal Disease and Kidney Function Decline in African Americans：The Jackson Heart Study[J]. J Periodontol，2015，86(10):1126-1132. DOI：10.1902/jop.2015.150195.
[14]	Almeida S, Figueredo CM, Lemos C，et al. Periodontal treatment in patients with chronic kidney disease：a pilot study[J]. J Periodontal Res，2017，52(2):262-267. DOI：10.1111/jre.12390.
[15]	Artese HP, Sousa CO, Luiz RR，et al. Effect of non-surgical periodontal treatment on chronic kidney disease patients[J]. Braz Oral Res，2010，24(4):449-454. DOI：10.1590/S1806-83242010000400013.
[16]	Fang F, Wu B, Qu Q，et al. The clinical response and systemic effects of non-surgical periodontal therapy in end-stage renal disease patients：a 6-month randomized controlled clinical trial [J]. J Clin Periodontol，2015，42(6):537-546. DOI：10.1111/jcpe.12411.
[17]	Tonetti MS, D′Aiuto F, Nibali L，et al. Treatment of periodontitis and endothelial function[J]. N Engl J Med，2007，356(9):911-920. DOI：10.1056/NEJMoa063186.
[18]	Langsford D, Tang M, Cheikh Hassan HI，et al. The Association between Biomarker Profiles，Etiology of Chronic Kidney Disease，and Mortality[J]. Am J Nephrol，2017，45(3):226-234. DOI：10.1159/000454991.
[19]	Graziani F, Cei S, La Ferla F，et al. Effects of non-surgical periodontal therapy on the glomerular filtration rate of the kidney：an exploratory trial[J]. J Clin Periodontol，2010，37(7):638-643. DOI：10.1111/j.1600-051X.2010.01578.x.
[20]	Scannapieco FA. Systemic effects of periodontal diseases[J]. Dent Clin North Am，2005，49(3):533-550,vi.
[21]	Kshirsagar AV, Offenbacher S, Moss KL，et al. Antibodies to periodontal organisms are associated with decreased kidney function. The Dental Atherosclerosis Risk In Communities study[J]. Blood Purif，2007，25(1):125-132.
[22]	Shankar A, Sun L, Klein BE，et al. Markers of inflammation predict the long-term risk of developing chronic kidney disease：a population-based cohort study[J]. Kidney Int，2011，80(11):1231-1238. DOI：10.1038/ki.2011.283.
[23]	Amdur RL, Feldman HI, Gupta J，et al. Inflammation and Progression of CKD：The CRIC Study[J]. Clin J Am Soc Nephrol，2016，11(9):1546-1556. DOI：10.2215/CJN.13121215.
[24]	Remuzzi G, Ruggenenti P, Perico N. Chronic renal diseases：renoprotective benefits of renin-angiotensin system inhibition [J]. Ann Intern Med，2002，136(8):604-615. DOI：10.7326/0003-4819-136-8-200204160-00010.
[25]	Brotto RS, Vendramini RC, Brunetti IL，et al. Lack of Correlation between Periodontitis and Renal Dysfunction in Systemically Healthy Patients[J]. Eur J Dent，2011，5(1):8-18.
[26]	Grubbs V, Plantinga LC, Crews DC，et al. Vulnerable populations and the association between periodontal and chronic kidney disease[J]. Clin J Am Soc Nephrol，2011，6(4):711-717. DOI：10.2215/CJN.08270910.
[27]	Akar H, Akar GC, Carrero JJ，et al. Systemic consequences of poor oral health in chronic kidney disease patients[J]. Clin J Am Soc Nephrol，2011，6(1):218-226. DOI：10.2215/CJN.05470610.
[28]	Pradeep AR, Kathariya R, Arjun Raju P，et al. Risk factors for chronic kidney diseases may include periodontal diseases，as estimated by the correlations of plasma pentraxin-3 levels：a case-control study[J]. Int Urol Nephrol，2012，44(3):829-839. DOI：10.1007/s11255-011-9997-7.
[29]	Anding K, Gross P, Rost JM，et al. The influence of uraemia and haemodialysis on neutrophil phagocytosis and antimicrobial killing[J]. Nephrol Dial Transplant，2003，18(10):2067-2073. DOI：10.1093/ndt/gfg330.
[30]	Chambrone L, Foz AM, Guglielmetti MR，et al. Periodontitis and chronic kidney disease：a systematic review of the association of diseases and the effect of periodontal treatment on estimated glomerular filtration rate[J]. J Clin Periodontol，2013，40(5):443-456. DOI：10.1111/jcpe.12067.
[31]	Davidovich E, Schwarz Z, Davidovitch M，et al. Oral findings and periodontal status in children，adolescents and young adults suffering from renal failure[J]. J Clin Periodontol，2005，32(10):1076-1082. DOI：10.1111/j.1600-051X.2005.00812.x.
[32]	Ertuğrul F, Elbek-Cubukçu C, Sabah E，et al. The oral health status of children undergoing hemodialysis treatment[J]. Turk J Pediatr，2003，45(2):108-113.
[33]	Ioannidou E, Swede H. Disparities in periodontitis prevalence among chronic kidney disease patients[J]. J Dent Res，2011，90(6):730-734. DOI：10.1177/0022034511402209.
[34]	Ruospo M, Palmer SC, Craig JC，et al. Prevalence and severity of oral disease in adults with chronic kidney disease：a systematic review of observational studies[J]. Nephrol Dial Transplant，2014，29(2):364-375. DOI：10.1093/ndt/gft401.
[35]	Ausavarungnirun R, Wisetsin S, Rongkiettechakorn N，et al. Association of dental and periodontal disease with chronic kidney disease in patients of a single，tertiary care centre in Thailand [J]. BMJ Open，2016，6(7):e011836. DOI：10.1136/bmjopen-2016-011836.
[36]	Tadakamadla J, Kumar S, Mamatha GP. Comparative evaluation of oral health status of chronic kidney disease（CKD）patients in various stages and healthy controls[J]. Spec Care Dentist，2014，34(3):122-126. DOI：10.1111/scd.12040.
[37]	Garcez J, Limeres Posse J, Carmona IT，et al. Oral health status of patients with a mild decrease in glomerular filtration rate[J]. Oral Surg Oral Med Oral Pathol Oral Radiol Endod，2009，107(2):224-228. DOI：10.1016/j.tripleo.2008.09.018.
[38]	Sharma P, Dietrich T, Sidhu A，et al. The periodontal health component of the Renal Impairment In Secondary Care（RIISC）cohort study：a description of the rationale，methodology and initial baseline results[J]. J Clin Periodontol，2014，41(7):653-661. DOI：10.1111/jcpe.12263.
[39]	Cohen G, Haag-Weber M, Horl WH. Immune dysfunction in uremia[J]. Kidney Int Suppl，1997(62):S79-S82.
[40]	Kato S, Chmielewski M, Honda H，et al. Aspects of immune dysfunction in end-stage renal disease[J]. Clin J Am Soc Nephrol，2008，3(5):1526-1533. DOI：10.2215/CJN.00950208.
[41]	Takeuchi Y, Ishikawa H, Inada M，et al. Study of the oral microbial flora in patients with renal disease[J]. Nephrology （Carlton），2007，12(2):182-190. DOI：10.1111/j.1440-1797.2007.00767.x.
[42]	Bastos JA, Diniz CG, Bastos MG，et al. Identification of periodontal pathogens and severity of periodontitis in patients with and without chronic kidney disease[J]. Arch Oral Biol，2011，56(8):804-811. DOI：10.1016/j.archoralbio.2010.12.006.
[43]	Salam SN, Eastell R, Khwaja A. Fragility fractures and osteoporosis in CKD：pathophysiology and diagnostic methods [J]. Am J Kidney Dis，2014，63(6):1049-1059. DOI：10.1053/j.ajkd.2013.12.016.
[44]	Klassen JT, Krasko BM. The dental health status of dialysis patients[J]. J Can Dent Assoc，2002，68(1):34-38.
[45]	Proctor R, Kumar N, Stein A，et al. Oral and dental aspects of chronic renal failure[J]. J Dent Res，2005，84(3):199-208.

Please choose a citation manager

Content to export