Research progress of circular RNA and its research prospects in tumor radiotherapy

doi:10.3877/cma.j.issn.1674-1366.2018.05.010

Abstract

Abstract:

Currently, radioresistance is one of the most difficult problems in the cancer treatment and its molecular mechanisms are still not well documented. Circular RNAs are a species of RNAs with closed loop structure in eukaryote, characterized by its tissue specificity, stability and easy detection. And it is closely associated with the cancer early diagnosis and radioresistance. Circular RNAs can serve as miRNA sponges to modulate the microRNAs and signal pathways of tumor radioresistance. Therefore, circular RNAs may be expected to be a novel type of biomarkers and therapeutic targets for enhancing the radiosensitivity of tumor. Here, we reviewed the research progress of circular RNAs and discussed its research prospects in tumor radiotherapy.

Key words: RNA, Circular, MicroRNA, Neoplasems, Radiotherapy

Guanhui Chen, Yiming Li, Dongsheng Yu. Research progress of circular RNA and its research prospects in tumor radiotherapy[J]. Chinese Journal of Stomatological Research(Electronic Edition), 2018, 12(05): 322-325.

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