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Chinese Journal of Stomatological Research(Electronic Edition) ›› 2017, Vol. 11 ›› Issue (04): 218-224. doi: 10.3877/cma.j.issn.1674-1366.2017.04.005

Special Issue:

• Clinic Research • Previous Articles     Next Articles

Meta analysis for the efficacy of pentoxifylline and vitamin E in treatment of osteoradionecrosis of jaw

Weiwei Xiao1, Yuanli Chen1, Chunlin Zong1, Lin Song1, Lei Tian1,()   

  1. 1. State Key Laboratory of Military Stomatology, National Clinical Research Center for Oral Diseases, Shaanxi Key Laboratory of Oral Diseases, Department of Cranio-facial Trauma and Orthognathic Surgery, School of Stomatology, The Fourth Military Medical University, Xi′an 710032, China
  • Received:2017-06-05 Online:2017-08-01 Published:2017-08-01
  • Contact: Lei Tian
  • About author:
    Correspondence: Tian Lei, Email:

Abstract:

Objective

To study the efficacy of pentoxifylline and vitamin E in treatment of osteoradionecrosis of jaw by Meta analysis.

Methods

Pubmed (1980-2017.02) , EMbase (1980-2017.02) , Cochrane library (2017.02) , the Chinese biomedical literature database (1980-2017.02) were retrieved about the randomized controlled trials of pentoxifylline and vitamin E in treatment of osteoradionecrosis of jaw, and the time extent was from January 1980 to February 2017. After objective evaluation of the retrieved paper quality, Cochrane collaboration with Rev Man 5.3 software system was applied to accomplish this Meta analysis.

Results

Five out of thirty eight paper were fully analyzed, the cured rate of treating osteoradionecrosis of jaw by pentoxifylline and vitamin E group was significantly higher than control group, and the difference was statistically significant (OR= 8.25, 95% CI: 1.84~ 36.94, P<0.05) .

Conclusions

Meta analysis shows the clinical effect of pentoxifylline and vitamin E in treatment of osteoradionecrosis of jaw is significant, but the direct and effective clinical evidence is still needed to be collected.

Key words: Pentoxifylline, Vitamin E, Osteoradionecrosis of jaw, Effeciveness, Meta analysis

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