Pathogenic factors of oral leukoplakia

doi:10.3877/cma.j.issn.1674-1366.2017.02.008

Abstract

Abstract:

Scholars had carried out extensive research of oral leukoplakia (oral leukoplakia, OLK) and published a number of papers, however, the aetiology of OLK did not reach a consensus. We collected eligible studies for reviewing and analyzing to explore the aetiological factor of OLK. According to the requisition of systematic evaluation, we formulated detailed standardization of the inclusion and exclusion criteria including contents of research, OLK diagnosed by histopathology and associated with aetiological factor of OLK. We retrieved articles from Pubmed, CNKI and Wanfang data base and found 406 articles related to OLK from January 2012 to July 2016. Retrieving part of the cited references in some literature, we downloaded and comprehended 103 which were consistent with the requirements of our research to analysis. The following search terms were used: "oral leukoplakia" AND "aetiological factors". The research indicated that the duration of smoking habits, the amount of cigarettes smoked and alcohol drank per day were significantly associated with the presence of oral leukoplakia. Local stimulation can cause damage of the oral mucosa and chronic inflammation leading to OLK. Candida infection and human papilloma virus (HPV) infection may lead to OLK and cause epithelial dysplasia of oral mucosa. Systemic factors such as saliva flora, trace elements, radiation, microcirculation changes and genetic factors can increase the risk of OLK.

Key words: Leukoplakia, oral, Aetiological factor, Cases analysis, Oral mucosa

Xinjia Cai, Zhigang Yao, Long Li, Gui Liu, Junjie Liu, Junhui Huang. Pathogenic factors of oral leukoplakia[J]. Chinese Journal of Stomatological Research(Electronic Edition), 2017, 11(02): 111-114.

/ / Recommend

Add to citation manager EndNote|Ris|BibTeX

URL: https://zhkqyxyjzz.cma-cmc.com.cn/EN/10.3877/cma.j.issn.1674-1366.2017.02.008

https://zhkqyxyjzz.cma-cmc.com.cn/EN/Y2017/V11/I02/111

References 34

[1]	褚青松，苗群爱，郅克谦，等. 150例口腔黏膜白斑的回顾分析[J].临床口腔医学杂志，2009，25(5):311-312.
[2]	夏娟，李秉琦，何园.欧洲及美国口腔黏膜病学研究进展——第一次欧美口腔黏膜病协会联合会议学术报告概要[J].临床口腔医学杂志，2002，18(3):224-225.
[3]	Sugár L, Bánóczy J. Follow-up studies in oral leukoplakia[J]. Bull World Health Organ，1969，41(2):289-293.
[4]	Marija BB, Nada V. Cigarette smoking as a risk factor associated with oral leukoplakia[J]. Archive of Oncology，2002，10(2):67-70.
[5]	杜建英.口腔粘膜白斑临床特点分析[J].中国保健营养，2012(3):82-83.
[6]	Maia HC, Pinto NA, Pereira Jdos S，et al. Potentially malignant oral lesions：clinicopathological correlations[J]. Einstein（Sao Paulo），2016，14(1):35-40.
[7]	Pindborg JJ, Kiaer J, Gupta PC，et al. Studies in oral leukoplakias. Prevalence of leukoplakia among 10，000 persons in Lucknow，India，with special reference to use of tobacco and betel nut[J]. Bull World Health Organ，1967，37(1):109-116.
[8]	凌日鼎，朱向民，黄仕春，等. 100例口腔黏膜白斑患者的临床分析及治疗[J].求医问药（学术版），2011，9(6):129-130.
[9]	蔡跃民.口腔粘膜白斑患者72例的临床分析及治疗[J].大家健康（下旬版），2012，6(12):6-7.
[10]	翁海勇，郑根建，云蔓，等.海南省老年人群口腔粘膜病及其危险因子调查[J].昆明医科大学学报，2015，36(9):87-91.
[11]	申德山.口腔粘膜白斑临床特点分析[J].中国卫生产业，2012(21):87.
[12]	乔金霞.口腔粘膜白斑（OLK）患者临床分析及治疗[J].中国现代药物应用，2010，4(6):69-70.
[13]	许国棋，史慧宝，丘新尧，等.吸烟与口腔白斑的关系[J].口腔医学，1982，2(4):181-184.
[14]	古丽·艾山，崔立丰，郅克谦，等.口腔粘膜白斑150例临床分析[J].陕西医学杂志，2009，38(6):710-711.
[15]	口腔粘膜病协作研究组.方祥忠，执笔.我国部分地区134，492人中口腔粘膜白斑的流行病学调查报告[J].临床口腔医学杂志，1986，2(1):1-5.
[16]	Naveen-Kumar B, Tatapudi R, Sudhakara-Reddy R，et al. Various forms of tobacco usage and its associated oral mucosal lesions[J]. J Clin Exp Dent，2016，8(2):e172-e177.
[17]	李刚，张博学.吸烟与口腔健康的研究现状[J].广东牙病防治，2001，9(2):143-144.
[18]	羊一平.部分人群吸烟引起口腔黏膜损害调查研究[J].口腔医学，2005，25(2):114-115.
[19]	Nada V, Marija BB, Dejan V，et al. Presence of Candida albicans in potentially malignant oral mucosal lesions[J]. Arch Oncol，2004，12(1):51-54.
[20]	Wu L, Feng J, Shi L，et al. Candidal infection in oral leukoplakia：a clinicopathologic study of 396 patients from eastern China[J]. Ann Diagn Pathol，2013，17(1):37-40.
[21]	戴青，孙正.口腔白斑伴上皮异常增生与念珠菌感染初步分析[J].北京口腔医学，2002，10(4):22,193.
[22]	侯炜，杨占秋，龙星，等.人乳头瘤病毒、疱疹病毒Ⅰ型及人巨细胞病毒与口腔鳞癌关系的研究[J].口腔医学，2000，20(4):180-181.
[23]	Saghravanian N, Ghazi N, Meshkat Z，et al. Human Papillomavirus in Oral Leukoplakia，Verrucous Carcinoma，Squamous Cell Carcinoma，and Normal Mucous Membrane[J]. Oman Med J，2015，30(6):455-460.
[24]	Bhargava A, Shakeel M, Srivastava AN，et al. Role of human papilloma virus in oral leukoplakia[J]. Indian J Cancer，2016，53(1):206-209.
[25]	Feller L, Lemmer J. Oral Leukoplakia as It Relates to HPV Infection：A Review[J]. Int J Dent，2012:540561.
[26]	Hu X, Zhang Q, Hua H，et al. Changes in the salivary microbiota of oral leukoplakia and oral cancer[J]. Oral Oncol，2016(56):e6-e8.
[27]	Mizuki H, Kawamura T, Nagasawa D. In situ immunohistochemical detection of intracellular Mycoplasma salivarium in the epithelial cells of oral leukoplakia[J]. J Oral Pathol Med，2015，44(2):134-144.
[28]	Ray JG, Ghosh R, Mallick D，et al. Correlation of trace elemental profiles in blood samples of indian patients with leukoplakia and oral submucous fibrosis[J]. Biol Trace Elem Res，2011，144(1-3):295-305.
[29]	杨敏.某市医用X线工作者口腔白斑病调查[J].中国工业医学杂志，2007，20(3):182.
[30]	张洁，张丁.糖尿病与口腔疾病的关系[J/CD].中华临床医师杂志（电子版），2008，2(9):1079-1085.
[31]	高黎，张彦喜，石爱梅.核因子-κBp65与IκBα因子在口腔白斑及鳞癌中的表达[J].实用口腔医学杂志，2009，25(1):58-61.
[32]	赵晓一，刘宏伟，魏明洁. TFAR19在口腔白斑和口腔鳞癌中表达的研究[J].实用口腔医学杂志，2005，21(5):648-652.
[33]	何伟，陈欢，陈卫民. Cyclin D1、Ki-67在口腔黏膜白斑和口腔鳞癌中的表达[J].河北联合大学学报（医学版），2016，18(2):139-144.
[34]	Gupta S, Gupta OP, Srivastava S. Role of CYP2E1 genetic polymorphism in the development of oral leukoplakia among tobacco users in North Indian population[J]. Indian J Cancer，2014，51(2):154-158.

Please choose a citation manager

Content to export