Diagnosis and treatment on oral lichen planus combining with esophageal lichen planus and review the related literatures

doi:10.3877/cma.j.issn.1674-1366.2015.02.009

Chinese Journal of Stomatological Research(Electronic Edition) ›› 2015, Vol. 09 ›› Issue (02): 134-139. doi: 10.3877/cma.j.issn.1674-1366.2015.02.009

Special Issue: ；

• Clinic Research • Previous Articles Next Articles

Diagnosis and treatment on oral lichen planus combining with esophageal lichen planus and review the related literatures

Jianhui He¹, Feng Huang², Ronglin Li³, Renxu Lai⁴, Xianping Yi⁵, Chunyang Li¹^,^†()

^1. Department of Stomatology, The fifth affiliated hospital of Sun Yat-sen University, Zhuhai 519000, China
^2. Zhuhai Hospital of Stomatology, Zhuhai 519000, China
^3. Guanghua School of Stomatology, Hospital of Stomatology, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Stomatology, Guangzhou 510055, China
^4. Department of Gastroenterology, The Fifth Affiliated Hospital of Sun Yat-sen University, Zhuhai 519000, China
^5. Department of Pathology, The Fifth Affiliated Hospital of Sun Yat-sen University, Zhuhai 519000, China

Received:2015-01-14 Online:2015-04-01 Published:2015-04-01
Contact: Chunyang Li
About author:
Corresponding author: Li Chunyang, Email: lichyang@mail.sysu.edu.cn, Tel: 0756-2528274

Abstract

Abstract:

Objective

To explore and report the clinical oral lichen planus (OLP) cases combining with esophageal lichen planus (ELP) , including prevalence, clinical manifestations, diagnosis, treatment and prognosis.

Methods

Two hundred and thirty-six OLP patients with chief-compliances and symptomes such as chest discomfort, chest burning, dysphagia, poor food intake et al. were included in this study. Esophagogastroscopy and biosy were suggested and applied to find weather combining with esophageal lichen planus (ELP) after written informed consent were obtained. Standard therapy of OLP and case follow-up were applied.

Results

Eighteen OLP patients with combined ELP were found (7.6%, 18/236) . Dysplasia were detected in 2 cases 11.1% (2/18) and in 1 case, 5.5% (1/18) , esophageal squamous cell carcinoma was detected while the three OLP was not malignant-transformed.

Conclusions

Lichen planus is general condition and there is a correlation between ELP and OLP. Thus, oral medicine doctors should pay attention to the other site lichen planus lesion to detect early and hiding malignant-transformed, avoided misdiagnosis and missed diagnosis.

Key words: Oral lichen planus, Esophageal lichen planus

Jianhui He, Feng Huang, Ronglin Li, Renxu Lai, Xianping Yi, Chunyang Li. Diagnosis and treatment on oral lichen planus combining with esophageal lichen planus and review the related literatures[J]. Chinese Journal of Stomatological Research(Electronic Edition), 2015, 09(02): 134-139.

/ / Recommend

Add to citation manager EndNote|Ris|BibTeX

URL: https://zhkqyxyjzz.cma-cmc.com.cn/EN/10.3877/cma.j.issn.1674-1366.2015.02.009

https://zhkqyxyjzz.cma-cmc.com.cn/EN/Y2015/V09/I02/134

Figures/Tables 12

References 15

[1]	Gorouhi F,Davari P,Fazel N. Cutaneous and mucosal lichen planus: a comprehensive review of clinical subtypes, risk factors, diagnosis, and prognosis[J]. Scientific World Journal, 2014(2014): 742826. doi: 10.1155/2014/742826.
[2]	中华口腔医学会口腔黏膜病专业委员会, 中华口腔医学会中西医结合专业委员会.口腔扁平苔藓诊疗指南(试行)[J].中华口腔医学杂志, 2012, 47(7): 399-401.
[3]	Lodi G,Carrozzo M,Furness S,Thongprasom K. Interventions for treating oral lichen planus: a systematic review[J]. Br J Dermatol, 2012, 166(5): 938-947.
[4]	Schottenfeld D,Beebe-Dimmer J. Chronic inflammation: a common and important factor in the pathogenesis of neoplasia[J]. CA Cancer J Clin, 2006, 56(2): 69-83.
[5]	Schultz H. Tobacco or health: A global status report[J]. Ann Saudi Med, 1998, 18(2): 195.
[6]	Chandan VS,Murray JA,Abraham SC. Esophageal lichen planus[J]. Arch Pathol Lab Med, 2008, 132(6): 1026-1029.
[7]	Fox LP,Lightdale CJ,Grossman ME. Lichen planus of the esophagus: what dermatologists need to know[J]. J Am Acad Dermatol, 2011, 65(1): 175-183.
[8]	Zvidi I,Geller A,Gal E, et al. Malignant transformation of esophageal lichen planus[J]. Isr Med Assoc J, 2012, 14(6): 395-396.
[9]	Wedgeworth EK,Vlavianos P,Groves CJ, et al. Management of symptomatic esophageal involvement with lichen planus[J]. J Clin Gastroenterol, 2009, 43(10): 915-919.
[10]	Eisen D. The evaluation of cutaneous, genital, scalp, nail, esophageal, and ocular involvement in patients with oral lichen planus[J]. Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 1999, 88(4): 431-436.
[11]	Dickens CM,Heseltine D,Walton S, et al. The oesophagus in lichen planus: an endoscopic study[J]. BMJ, 1990, 300(6717): 84.
[12]	陈谦明.口腔粘膜病学[M]. 4版.北京: 人民卫生出版社, 2012.
[13]	Sugerman PB,Savage NW,Walsh LJ, et al. The pathogenesis of oral lichen planus[J]. Crit Rev Oral Biol Med, 2002, 13(4): 350-365.
[14]	Köksal AS,Yildiz H,Odemi B, et al. Treatment of esophageal stricture due to lichen planus with intralesional corticosteroid injection[J]. Surg Laparosc Endosc Percutan Tech, 2014, 24(1): e32-e34.
[15]	Chaklader M,Morris-Larkin C,Gulliver W, et al. Cyclosporine in the management of esophageal lichen planus[J]. Can J Gastroenterol, 2009, 23(10): 686-688.

部位	上皮过角化或不全角化	基底细胞液化变性	固有层淋巴细胞浸润	上皮异常增生	鳞状上皮癌
口腔	18	18	18	0	0
食道	15	18	18	2(11.1%)	1(5.5%)

部位	上皮过角化或不全角化	基底细胞液化变性	固有层淋巴细胞浸润	上皮异常增生	鳞状上皮癌
口腔	18	18	18	0	0
食道	15	18	18	2(11.1%)	1(5.5%)

Please choose a citation manager

Content to export

Diagnosis and treatment on oral lichen planus combining with esophageal lichen planus and review the related literatures

RichHTML

PDF (PC)

Knowledge