Abstract:

Objective

To investigate non-traumatic method for treatment of infantile venous malformation located in parotid masseteric regions， and to evaluate its clinical effect.

Methods

Nineteen patients were treated by intralesional injections of Pinyangmycin. The processes were repeated at an interval of one week， but not more than 4 injections within a treatment period. In case of necessary， the secondary period was performed 2 weeks later. The general and local adverse responses were recorded and the clinical outcomes were followed-up from 1 to 3 years.

Results

Complete clinical resolutions were achieved in 16 patients after 3 to 8 injections. The venous malformations disappeared and were replaced by normal skins. No ulceration or allergy was found during the treatment. No clinical recurrence or scar was observed through out follow-up. The functions of facial nerve were remained normally in all patients. 3 patients with huge venous malformations received surgical management or laser therapy combined with sclerotherapy after 4 injections for their poor clinical results. Operative scars and slight depression deformities in parotid gland regions were observed in 3 patients. Symptoms of facial nerve damage appeared in infant receiving operative treatment. No recurrence was found in all cases as well.

Conclusions

Treatment of infantile venous malformation in parotid gland region with intralesional injections of pinyangmycin revealed a high rate of complete clinical resolution，and did not damage facial nerve or form facial scar. It could be regarded as an effective and nontraumatic therapeutic method for infantile venous malformations in parotid masseteric regions.Comprehensive treatments might be employed in huge lesions.

Key words: Infant, Parotid masseteric region, Venous malformation, Pingyangmycin, Sclerotherapy