Abstract:
Objective
To evaluate the efficacy and safety of pingyangmycin（PYM）complex in the treatment of oral and maxillofacial vascular malformations（VMs）.
Methods
A total of 64 patients with oral and maxillofacial VMs admitted to our department from 2007 to 2021 were enrolled，including 42 patients treated with PYM complex and 22 patients treated with traditional PYM solution. Diagnosis was confirmed based on imaging findings，and treatment outcomes were evaluated according to Achauer's grading criteria. Statistical analyses，including independent sample t-tests and chi-square tests，were performed using software（SPSS，v=25.0）.
Results
The efficacy of PYM complex group was significantly better than that of traditional PYM group（χ2=6.141，P=0.013）. Moreover，in patients with only one injection，the effective rate of PYM complex group（85%）was significantly higher than that of traditional PYM group（40%）（χ2=7.704，P=0.006）. For lymphatic malformations，the efficacy of PYM complex treatment was superior in macrocystic lesions compared to microcystic ones（χ2=10.585，P=0.001）.PYM complex had a good and safe therapeutic effect，especially for venous malformations and macrocystic lymphatic malformations. Overall，the PYM complex group significantly enhanced therapeutic outcomes and reduced the number of treatment sessions.
Conclusions
The use of PYM complex in the treatment of oral and maxillofacial vascular malformations could effectively reduce the tumor volume，improve the treatment effect，reduce the number of treatments，and improve the treatment satisfaction of patients with less medical burden and good safety.
Key words:
Oral and maxillofacial region vascular anomalies,
Venous malformations,
Bleomycin,
Pingyangmycin complex,
Sclerotherapy
Congyuan Cao, Shuojin Huang, Qianting He, Anxun Wang. The therapeutic efficacy and safety of pingyangmycin complex in the treatment of oral and maxillofacial vascular malformations[J]. Chinese Journal of Stomatological Research(Electronic Edition), 2024, 18(06): 368-374.