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中华口腔医学研究杂志(电子版) ›› 2025, Vol. 19 ›› Issue (03) : 204 -209. doi: 10.3877/cma.j.issn.1674-1366.2025.03.008

综述

硼中子俘获疗法对口腔正常组织的辐射损伤研究现状
汪芷怡1,2,3, 吴家惠4, 沈世教3, 蓝玺月4, 马琳1,2,()   
  1. 1. 深圳大学总医院口腔科,深圳 518055
    2. 深圳大学口腔医学研究所,深圳 518055
    3. 深圳大学医学部口腔医学院,深圳 518055
    4. 深圳大学医学部临床医学院,深圳 518055
  • 收稿日期:2025-01-12 出版日期:2025-06-01
  • 通信作者: 马琳
  • 基金资助:
    国家自然科学基金(82203967)广东省基础与应用基础研究基金(2023A1515011945)深圳市科技计划(JCYJ20240813142112017)

Radiation-induced oral tissue injury during boron neutron capture therapy to head and neck cancers

Zhiyi Wang1,2,3, Jiahui Wu4, Shijiao Shen3, Xiyue Lan4, Lin Ma1,2,()   

  1. 1. Department of Stomatology, Shenzhen University General Hospital,Shenzhen University,Shenzhen 518055,China
    2. Institute of Stomatological Research,Shenzhen University,Shenzhen 518055,China
    3. School of Dentistry,Medical School,Shenzhen University,Shenzhen 518055,China
    4. School of Clinical Medicine,Shenzhen University,Shenzhen 518055,China
  • Received:2025-01-12 Published:2025-06-01
  • Corresponding author: Lin Ma
引用本文:

汪芷怡, 吴家惠, 沈世教, 蓝玺月, 马琳. 硼中子俘获疗法对口腔正常组织的辐射损伤研究现状[J/OL]. 中华口腔医学研究杂志(电子版), 2025, 19(03): 204-209.

Zhiyi Wang, Jiahui Wu, Shijiao Shen, Xiyue Lan, Lin Ma. Radiation-induced oral tissue injury during boron neutron capture therapy to head and neck cancers[J/OL]. Chinese Journal of Stomatological Research(Electronic Edition), 2025, 19(03): 204-209.

硼中子俘获治疗(BNCT)作为一种前沿的癌症治疗方法,因其优异的二元性细胞级损伤特征而备受关注。然而,由于载硼药物肿瘤靶向性及中子束精准度等限制,BNCT临床应用于头颈部肿瘤时常常会对口腔正常组织产生损伤,影响疗程及患者生存质量,是临床上关注的重要研究问题。本文综述了BNCT 的辐射特征、BNCT 辐射对口腔正常组织的损伤及其机制。辐射防护剂、血管修复治疗和中医药治疗等可作为BNCT 正常组织损伤的防治策略。未来研究应关注BNCT 中正常组织损伤机制并针对损伤靶点开发有效辐射防护剂,提升BNCT 的疗效和安全性,改善患者预后和生活质量。

As a cutting-edge cancer treatment,boron neutron capture therapy(BNCT)has attracted attentions due to its excellent characteristics of cell-level damage. However,due to the tumor-targeting limitation of boron drugs and delivery accuracy of neutron beam,oral normal tissues are injured by radiation during BNCT of head and neck cancers,which affecting the completion of treatment and quality of patients'life. This article reviews the radiation characteristics of BNCT,as well as the damage of radiation to normal oral tissues during BNCT and its mechanisms,such as radiation-induced oral mucositis,vascular injury and salivary gland injury. Radiation protection agents,vascular repair treatments and traditional Chinese medicine treatments can be used as prevention or treatment strategies for normal tissue injury after BNCT. Future research should focus on the mechanism of normal tissue damage in BNCT and develop effective radiation protection agents for injury targets,so as to improve the efficacy and safety of BNCT and improve the prognosis and quality of life of patients.

图1 硼中子俘获治疗(BNCT)在头颈部癌症治疗过程中,对口腔正常组织的腺体、黏膜及血管造成放射性损伤示意图
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