| [1] |
Baidoo KE, Yong K, Brechbiel MW. Molecular pathways：Targeted alpha-particle radiation therapy[J]. Clin Cancer Res， 2013， 19（3）：530-537. DOI： 10.1158/1078-0432.CCR-12-0298. |
| [2] |
Lang X, Green MD, Wang W，et al. Radiotherapy and immunotherapy promote tumoral lipid oxidation and ferroptosis via synergistic repression of SLC7A11[J]. Cancer Discov， 2019， 9（12）：1673-1685. DOI： 10.1158/2159-8290.Cd-19-0338. |
| [3] |
Lei G, Zhang Y, Koppula P，et al. The role of ferroptosis in ionizing radiation-induced cell death and tumor suppression[J]. Cell Res， 2020， 30（2）：146-162. DOI： 10.1038/s41422-019-0263-3. |
| [4] |
Dixon SJ, Lemberg KM, Lamprecht MR，et al. Ferroptosis：An iron-dependent form of nonapoptotic cell death[J]. Cell， 2012， 149（5）：1060-1072. DOI： 10.1016/j.cell.2012.03.042. |
| [5] |
Tang D, Chen X, Kang R，et al. Ferroptosis：Molecular mechanisms and health implications[J]. Cell Res， 2021， 31（2）：107-125. DOI： 10.1038/s41422-020-00441-1. |
| [6] |
Stockwell BR, Friedmann Angeli JP, Bayir H，et al. Ferroptosis：A regulated cell death nexus linking metabolism，redox biology，and disease[J]. Cell， 2017， 171（2）：273-285. DOI： 10.1016/j.cell.2017.09.021. |
| [7] |
Masaldan S, Clatworthy SAS, Gamell C，et al. Iron accumulation in senescent cells is coupled with impaired ferritinophagy and inhibition of ferroptosis[J]. Redox Biol， 2018， 14：100-115. DOI： 10.1016/j.redox.2017.08.015. |
| [8] |
Picard V, Govoni G, Jabado N，et al. Nramp 2（DCT1/DMT1）expressed at the plasma membrane transports iron and other divalent cations into a calcein-accessible cytoplasmic pool[J]. J Biol Chem， 2000， 275（46）：35738-35745. DOI： 10.1074/jbc.M005387200. |
| [9] |
Sterling J, Guttha S, Song Y，et al. Iron importers Zip8 and Zip14 are expressed in retina and regulated by retinal iron levels [J]. Exp Eye Res， 2017， 155：15-23. DOI： 10.1016/j.exer.2016.12.008. |
| [10] |
Doll S, Proneth B, Tyurina YY，et al. ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition[J]. Nat Chem Biol， 2017， 13（1）：91-98. DOI： 10.1038/nchembio.2239. |
| [11] |
Yang WS, SriRamaratnam R, Welsch ME，et al. Regulation of ferroptotic cancer cell death by GPX4[J]. Cell， 2014， 156（1/2）：317-331. DOI： 10.1016/j.cell.2013.12.010. |
| [12] |
Jiang X, Stockwell BR, Conrad M. Ferroptosis：Mechanisms，biology and role in disease[J]. Nat Rev Mol Cell Biol， 2021， 22（4）：266-282. DOI： 10.1038/s41580-020-00324-8. |
| [13] |
Chen X, Kang R, Kroemer G，et al. Broadening horizons：The role of ferroptosis in cancer[J]. Nat Rev Clin Oncol， 2021， 18（5）：280-296. DOI： 10.1038/s41571-020-00462-0. |
| [14] |
Azzam EI, Jay-Gerin JP, Pain D. Ionizing radiation-induced metabolic oxidative stress and prolonged cell injury[J]. Cancer Lett， 2012， 327（1/2）：48-60. DOI： 10.1016/j.canlet.2011.12.012. |
| [15] |
Ye LF, Chaudhary KR, Zandkarimi F，et al. Radiation-induced lipid peroxidation triggers ferroptosis and synergizes with ferroptosis inducers[J]. ACS Chem Biol， 2020， 15（2）：469-484. DOI： 10.1021/acschembio.9b00939. |
| [16] |
Thermozier S, Hou W, Zhang X，et al. Anti-ferroptosis drug enhances total-body irradiation mitigation by drugs that block apoptosis and necroptosis[J]. Radiat Res， 2020， 193（5）：435-450. DOI： 10.1667/rr15486.1. |
| [17] |
Ivanov SD, Semenov AL, Mikhelson VM，et al. Effects of iron ion additional introduction in radiation therapy of tumor-bearing animals[J]. Radiats Biol Radioecol， 2013， 53（3）：296-303. DOI： 10.7868/s0869803113030065. |
| [18] |
Ivanov SD, Semenov AL, Kovan′ko EG，et al. Effects of iron ions and iron chelation on the efficiency of experimental radiotherapy of animals with gliomas[J]. Bull Exp Biol Med， 2015， 158（6）：800-803. DOI： 10.1007/s10517-015-2865-1. |
| [19] |
Xu Y, Wang Q, Li X，et al. Itraconazole attenuates the stemness of nasopharyngeal carcinoma cells via triggering ferroptosis[J]. Environ Toxicol， 2020， 36（2）：257-266. DOI： 10.1002/tox.23031. |
| [20] |
Tomita K, Fukumoto M, Itoh K，et al. MiR-7-5p is a key factor that controls radioresistance via intracellular Fe 2+ content in clinically relevant radioresistant cells[J]. Biochem Biophys Res Commun， 2019， 518（4）：712-718. DOI： 10.1016/j.bbrc.2019.08.117. |
| [21] |
Chen G, Li Y, He Y，et al. Upregulation of circular RNA circATRNL1 to sensitize oral squamous cell carcinoma to irradiation[J]. Mol Ther Nucleic Acids， 2020， 19：961-973. DOI： 10.1016/j.omtn.2019.12.031. |
| [22] |
Cobler L, Zhang H, Suri P，et al. xCT inhibition sensitizes tumors to γ-radiation via glutathione reduction[J]. Oncotarget， 2018， 9（64）：32280-32297. DOI： 10.18632/oncotarget.25794. |
| [23] |
Zhao Y, Li Y, Zhang R，et al. The role of erastin in ferroptosis and its prospects in cancer therapy[J]. Onco Targets Ther， 2020， 13：5429-5441. DOI： 10.2147/OTT.S254995. |
| [24] |
Shibata Y, Yasui H, Higashikawa K，et al. Erastin，a ferroptosis-inducing agent，sensitized cancer cells to X-ray irradiation via glutathione starvation in vitro and in vivo[J]. PLoS One， 2019， 14（12）：e0225931. DOI： 10.1371/journal.pone.0225931. |
| [25] |
Pan X, Lin Z, Jiang D，et al. Erastin decreases radioresistance of NSCLC cells partially by inducing GPX4-mediated ferroptosis [J]. Oncol Lett， 2019， 17（3）：3001-3008. DOI： 10.3892/ol.2019.9888. |
| [26] |
Hammer CT, Wills ED. The effect of ionizing radiation on the fatty acid composition of natural fats and on lipid peroxide formation[J]. Int J Radiat Biol Relat Stud Phys Chem Med， 1979， 35（4）：323-332. DOI： 10.1080/09553007914550391. |
| [27] |
Koike N, Kota R, Naito Y，et al. 2-Nitroimidazoles induce mitochondrial stress and ferroptosis in glioma stem cells residing in a hypoxic niche[J]. Commun Biol， 2020， 3（1）：450. DOI： 10.1038/s42003-020-01165-z. |
| [28] |
Zhang X, Tian M, Li X，et al. Hematopoietic protection and mechanisms of ferrostatin-1 on hematopoietic acute radiation syndrome of mice[J]. Int J Radiat Biol， 2021， 97（4）：464-473. DOI： 10.1080/09553002.2021.1876956. |
| [29] |
Zhang X, Xing X, Liu H，et al. Ionizing radiation induces ferroptosis in granulocyte-macrophage hematopoietic progenitor cells of murine bone marrow[J]. Int J Radiat Biol， 2020， 96（5）：584-595. DOI： 10.1080/09553002.2020.1708993. |
| [30] |
Xie LW, Cai S, Zhao TS，et al. Green tea derivative（-）-epigallocatechin-3-gallate（EGCG）confers protection against ionizing radiation-induced intestinal epithelial cell death both in vitro and in vivo[J]. Free Radic Biol Med， 2020， 161：175-186. DOI： 10.1016/j.freeradbiomed.2020.10.012. |
| [31] |
Li X, Zhuang X, Qiao T. Role of ferroptosis in the process of acute radiation-induced lung injury in mice[J]. Biochem Biophys Res Commun， 2019， 519（2）：240-245. DOI： 10.1016/j.bbrc.2019.08.165. |
| [32] |
Li X, Duan L, Yuan S，et al. Ferroptosis inhibitor alleviates radiation-induced lung fibrosis（RILF）via down-regulation of TGF-β1[J]. J Inflamm（Lond）， 2019， 16：11. DOI： 10.1186/s12950-019-0216-0. |
| [33] |
|
| [34] |
Wang W, Green M, Choi JE，et al. CD8 + T cells regulate tumour ferroptosis during cancer immunotherapy[J]. Nature， 2019， 569（7755）：270-274. DOI： 10.1038/s41586-019-1170-y. |
| [35] |
Wan C, Sun Y, Tian Y，et al. Irradiated tumor cell-derived microparticles mediate tumor eradication via cell killing and immune reprogramming[J]. Sci Adv， 2020， 6（13）：eaay9789. DOI： 10.1126/sciadv.aay9789. |
| [36] |
Li H, Zhang X, Yi C，et al. Ferroptosis-related gene signature predicts the prognosis in oral squamous cell carcinoma patients[J]. BMC Cancer， 2021， 21（1）：835. DOI： 10.1186/s12885-021-08478-0. |
| [37] |
Sato H, Shiiya A, Kimata M，et al. Redox imbalance in cystine/glutamate transporter-deficient mice[J]. J Biol Chem， 2005， 280（45）：37423-37429. DOI： 10.1074/jbc.M506439200. |