Progress on the application of extracellular vesicle-functionalized biomaterials in the prevention and treatment of peri-implantitis

doi:10.3877/cma.j.issn.1674-1366.2026.04.008

Abstract

Abstract:

Peri-implantitis is a major cause of implant failure, and conventional treatments are limited by incomplete debridement, insufficient drug concentration, and poor bone regeneration capacity. Extracellular vesicles (EVs), as membrane-enclosed structures secreted by cells, show promise in regulating inflammation, promoting tissue regeneration, and enabling targeted therapy. However, natural EVs suffer from insufficient targeting and rapid clearance in vivo. The functional combination of EVs with biomaterials enables local sustained release, enhanced stability, and synergistic promotion of bone regeneration together with scaffold materials. This article reviews the construction strategies for EV-functionalized biomaterials and the research progress on the application of engineered EVs in the prevention and treatment of peri-implantitis, aiming to provide novel engineering strategies and theoretical foundations for the precise management of peri-implantitis.

Key words: Peri-implantitis, Extracellular vesicles, Biomaterials, Osteogenic differentiation, Precision therapy, Engineering modification, Immunomodulation

Guowen Ma, Yanru Liu, Beimin Tian, Jun Ju, Yi Tian, Xiyu Zhang, Faming Chen, Jia Wang. Progress on the application of extracellular vesicle-functionalized biomaterials in the prevention and treatment of peri-implantitis[J]. Chinese Journal of Stomatological Research(Electronic Edition), 2026, 20(04): 311-318.

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